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Transurethral resection of the prostate (TURP)
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IS THIS A PATTERN???? Thoughts and helpful ideas to guide a path
Diagnosed Gleason 9 advanced, PSA 19, mets in pelvis(maybe more???)Had 6 x chemo ,5 X radio to prostate, ADT through out.PSA was down to 0.08 at one point.1 MARCH23 0.29 25 MAY23 0.08 NOV23 0.12 05 DEC23 0.25 12 FEB24 0.44 started feeling bouts of unreasonable tiredness, think maybe active cancer???
Diagnosed Gleason 9 advanced, PSA 19, mets in pelvis(maybe more???)Had 6 x chemo ,5 X radio to prostate, ADT through out.PSA was down to 0.08 at one point.1 MARCH23 0.29 25 MAY23 0.08 NOV23 0.12 05 DEC23 0.25 12 FEB24 0.44 started feeling bouts of unreasonable tiredness, think maybe active cancer???
Mrtroxely
in
Advanced Prostate Cancer
5 months ago
Is there seasonality to testosterone levels?
My ADT treatments (Lupron/Abiraterone/Prednisone) ended on May 02 2023 at which point both my PSA and Testosterone were flat lined. Here are the results of the four times I have been tested since the end of the ADT. * Aug 18 2023: PSA is 0.09, Testosterone is 3.3 nmol/l (95.2 ng/dL), Testosterone
My ADT treatments (Lupron/Abiraterone/Prednisone) ended on May 02 2023 at which point both my PSA and Testosterone were flat lined. Here are the results of the four times I have been tested since the end of the ADT. * Aug 18 2023: PSA is 0.09, Testosterone is 3.3 nmol/l (95.2 ng/dL), Testosterone
Mascouche
in
Advanced Prostate Cancer
5 months ago
ok, last one before Christmas: AsiDNA (DT-01)
promising multi cancer Dbait (double-strand breaks (DSBs) family https://www.labiotech.eu/trends-news/onxeo-study-prostate-cancer-drug/ https://www.pharmaceutical-technology.com/data-insights/asidna-valerio-therapeutics-metastatic-castration-resistant-prostate-cancer-mcrpc-likelihood-of-approval-2/
promising multi cancer Dbait (double-strand breaks (DSBs) family https://www.labiotech.eu/trends-news/onxeo-study-prostate-cancer-drug/ https://www.pharmaceutical-technology.com/data-insights/asidna-valerio-therapeutics-metastatic-castration-resistant-prostate-cancer-mcrpc-likelihood-of-approval-2/
Maxone73
in
Advanced Prostate Cancer
7 months ago
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PSA rise
I have been undetectable for about 2 years. On Dec 6 my PSA was 0.04 then on March 19 it was 0.21 so this indicates a rise in Mets. Is this too low for a scan? What should be the next steps?
I have been undetectable for about 2 years. On Dec 6 my PSA was 0.04 then on March 19 it was 0.21 so this indicates a rise in Mets. Is this too low for a scan? What should be the next steps?
Howard53545
in
Advanced Prostate Cancer
4 months ago
18F-flotufolastat PET alters treatment approach for nearly 90% of patients with recurrent prostate cancer
"18F-flotufolastat is approved by the FDA for use in patients with suspected prostate cancer metastasis who are potentially curable by definitive surgery or radiation, and patients with suspected prostate cancer recurrence based on elevated PSA levels." https://www.urologytimes.com/view/18f-flotufolastat-pet-alters-treatment-approach-for-nearly
"18F-flotufolastat is approved by the FDA for use in patients with suspected prostate cancer metastasis who are potentially curable by definitive surgery or radiation, and patients with suspected prostate cancer recurrence based on elevated PSA levels." https://www.urologytimes.com/view/18f-flotufolastat-pet-alters-treatment-approach-for-nearly
Maxone73
in
Advanced Prostate Cancer
5 months ago
PSMA PET Looks Good But PSA Rising
Hello, I am hoping someone can help us understand what we might be missing prior to meeting with MO this week. My husband was diagnosed with metastatic prostate cancer with mets to pelvic lymph node and a few spots in bones in early January 2022 at 56 years old. He was successfully treated with Triplet
Hello, I am hoping someone can help us understand what we might be missing prior to meeting with MO this week. My husband was diagnosed with metastatic prostate cancer with mets to pelvic lymph node and a few spots in bones in early January 2022 at 56 years old. He was successfully treated with Triplet
FaithOverFear104
in
Advanced Prostate Cancer
5 months ago
Help with Results
I just updated my Bio and just received my PSMA Gallium scan results. Appointment is tomorrow to review but from what I see even with a low PSA of 0.052 a lymph node lit up which is rare. Is this correct and given this my guess SOC is whole pelvic adjuvant radiation and higher dose to lymph nodes or?
I just updated my Bio and just received my PSMA Gallium scan results. Appointment is tomorrow to review but from what I see even with a low PSA of 0.052 a lymph node lit up which is rare. Is this correct and given this my guess SOC is whole pelvic adjuvant radiation and higher dose to lymph nodes or?
Peppertree602
in
Advanced Prostate Cancer
4 months ago
PSA rise due to physical activity
My PSA has been rising slowly.. 4-5 points in 3 months. Until January when it went from 29 to 43 in one month. By end of February it was still at 43. I feel fine! Here is a quote from the National Library of Medicine: “Physical activity releases prostate-specific antigen (PSA) from the prostate
My PSA has been rising slowly.. 4-5 points in 3 months. Until January when it went from 29 to 43 in one month. By end of February it was still at 43. I feel fine! Here is a quote from the National Library of Medicine: “Physical activity releases prostate-specific antigen (PSA) from the prostate
Ian99
in
Advanced Prostate Cancer
4 months ago
Failed RP & SRT; Negative PSMA PET
Greetings. I had a radical prostatectomy that failed and then salvage radiation therapy that appears to have failed as well. A recent PSMA PET scan showed no signs of recurrent prostate cancer or metastases. By way of background: NOV 2010 - Dx at age 52; positive DRE, Gleason 3+3, PSA 5.0; prostate
Greetings. I had a radical prostatectomy that failed and then salvage radiation therapy that appears to have failed as well. A recent PSMA PET scan showed no signs of recurrent prostate cancer or metastases. By way of background: NOV 2010 - Dx at age 52; positive DRE, Gleason 3+3, PSA 5.0; prostate
dans_journey
in
Advanced Prostate Cancer
5 months ago
Treatment Plan
To update my journey, diagnosed on Oct. 2023 with pc, psa of 24.6. PSMA scan showed one met to sacrum, everything else clear. Did 28 rounds radiation and am currently on Lupron and Xtandi. Urologist yesterday said Lupron for one year then off and watch PSA with new PSMA scan also. Medical oncologist
To update my journey, diagnosed on Oct. 2023 with pc, psa of 24.6. PSMA scan showed one met to sacrum, everything else clear. Did 28 rounds radiation and am currently on Lupron and Xtandi. Urologist yesterday said Lupron for one year then off and watch PSA with new PSMA scan also. Medical oncologist
Jeffdanger
in
Advanced Prostate Cancer
4 months ago
Embark Phase 3 clinical trial
Came across this today --- https://www.health.harvard.edu/blog/after-prostate-cancer-treatment-a-new-standard-of-care-for-rising-psa-202312203001
Came across this today --- https://www.health.harvard.edu/blog/after-prostate-cancer-treatment-a-new-standard-of-care-for-rising-psa-202312203001
chefjlu
in
Advanced Prostate Cancer
7 months ago
Short-term tactics to keep PSA in check
Good morning fellow warriors. My docetaxel adventure was without side effects but gave an ineffective response. The cabazitaxel/carboplatin combo was effective but brutal in its attack on my immune system. Having had no treatment at all while my body tries to recover, I'm currently being considered by
Good morning fellow warriors. My docetaxel adventure was without side effects but gave an ineffective response. The cabazitaxel/carboplatin combo was effective but brutal in its attack on my immune system. Having had no treatment at all while my body tries to recover, I'm currently being considered by
CrocodileShoes
in
Advanced Prostate Cancer
4 months ago
Chemo or no/not yet?
59 years old. Metastatic/high volume. PSA hit 366 before starting Abiraterone and Degarelix. Start Lupron next week. Negative on DNA test. Will see what PSA looks like next week after a month of ADT. My question chemo, no chemo or wait on chemo? Onco and Rad Onco both seemed to have a very soft attitude
59 years old. Metastatic/high volume. PSA hit 366 before starting Abiraterone and Degarelix. Start Lupron next week. Negative on DNA test. Will see what PSA looks like next week after a month of ADT. My question chemo, no chemo or wait on chemo? Onco and Rad Onco both seemed to have a very soft attitude
4tunate1
in
Advanced Prostate Cancer
4 months ago
new PSA
my PSA rose from .04 in Jan to now .21 so it’s moving up. I assume this is still too low for a scan to determine where pc is at. I was undetected for 2 years after radiation of pelvic area.
my PSA rose from .04 in Jan to now .21 so it’s moving up. I assume this is still too low for a scan to determine where pc is at. I was undetected for 2 years after radiation of pelvic area.
Howard53545
in
Advanced Prostate Cancer
4 months ago
PSA increasing
My Dad’s PSA started increasing 2.5 years after diagnosis. It was 0.008 in December, 0.024 at the beginning of March and 0.029 on yesterday. Please advise. Any suggestions are greatly appreciated. He is still taking Lupron, Abiraterone and Prednisone 10 mg that were started back in September of 2021.
My Dad’s PSA started increasing 2.5 years after diagnosis. It was 0.008 in December, 0.024 at the beginning of March and 0.029 on yesterday. Please advise. Any suggestions are greatly appreciated. He is still taking Lupron, Abiraterone and Prednisone 10 mg that were started back in September of 2021.
Simonapo
in
Advanced Prostate Cancer
4 months ago
ONCT-534
Greetings, Recently I read that the FDA is now fast tracking this new drug— ONCT-534. Apparently it’s meant to follow-up on drugs such as Abiraterone and Xtandi once they have failed. I’m curious if anyone here is participating in the trial — phase1/2–and if anyone has any information outside of the
Greetings, Recently I read that the FDA is now fast tracking this new drug— ONCT-534. Apparently it’s meant to follow-up on drugs such as Abiraterone and Xtandi once they have failed. I’m curious if anyone here is participating in the trial — phase1/2–and if anyone has any information outside of the
Lavender22
in
Advanced Prostate Cancer
7 months ago
SMYD3 enzyme involved in metastases
From msn Fullscreen button SMYD3 loss impedes PCa progression.(A) Expression of SMYD3 mRNA from TCGA [GTEX normal (n = 105), TCGA tumor adjacent normal (n = 49), primary tumors (n = 495)], Gulzar et al. [normal (n = 35), primary tumor (n = 43)] (30), and Ross-Adams et al. [normal (n = 73), primary
From msn Fullscreen button SMYD3 loss impedes PCa progression.(A) Expression of SMYD3 mRNA from TCGA [GTEX normal (n = 105), TCGA tumor adjacent normal (n = 49), primary tumors (n = 495)], Gulzar et al. [normal (n = 35), primary tumor (n = 43)] (30), and Ross-Adams et al. [normal (n = 73), primary
Derf4223
in
Advanced Prostate Cancer
7 months ago
Which treatment option best for recurrent oligo?
In addition to SBRT for the two mets that make me join the happy recurrent crowd, what would be my best treatment option? I have had no SOC medication for 2.5 years. My T is 4 European scale 110 US scale. 1 Only ADT for seven months. This is what MO recommends, besides SBRT, since stronger/longer
In addition to SBRT for the two mets that make me join the happy recurrent crowd, what would be my best treatment option? I have had no SOC medication for 2.5 years. My T is 4 European scale 110 US scale. 1 Only ADT for seven months. This is what MO recommends, besides SBRT, since stronger/longer
Purple-Bike
in
Advanced Prostate Cancer
5 months ago
PSA on the way up again
I am getting a little concerned about a increase in my PSA, and not just the increase, but also the increase in the rate of increase. Short history. Diagnosed March 2021 by MRI and biopsy Gleason 4 + 3, Stage T3B, ISUP 3 ADT (Zoladex) started June 2021 EBRT 60Gy in 20 fractions December 2021 Last
I am getting a little concerned about a increase in my PSA, and not just the increase, but also the increase in the rate of increase. Short history. Diagnosed March 2021 by MRI and biopsy Gleason 4 + 3, Stage T3B, ISUP 3 ADT (Zoladex) started June 2021 EBRT 60Gy in 20 fractions December 2021 Last
ParrotY
in
Prostate Cancer Network
4 months ago
Dutasteride Monotherapy is effective for Newly Diagnosed PCa men not on ADT
This plot shows men that either don't have PCa (Group A) or newly diagnosed men with PCa by biopsy (Group B). Neither group is on ADT. Dutasteride monotherapy (0.5 mg/day) causes an average drop in PSA of about 50% in both Groups, and an average drop of about 20% in prostate volume. In one man, his
This plot shows men that either don't have PCa (Group A) or newly diagnosed men with PCa by biopsy (Group B). Neither group is on ADT. Dutasteride monotherapy (0.5 mg/day) causes an average drop in PSA of about 50% in both Groups, and an average drop of about 20% in prostate volume. In one man, his
janebob99
in
Prostate Cancer Network
4 months ago
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