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Transurethral resection of the prostate (TURP)
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FDA approves a new IND application of 225Ac-J591 (Actinium)
The FDA has granted clearance to an investigational new drug (IND) application for 225Ac-J591 (CONV01-α), a prostate-specific membrane antigen-targeted monoclonal antibody under investigation for the treatment of patients with advanced prostate cancer, announced Convergent Therapeutics, the developer
The FDA has granted clearance to an investigational new drug (IND) application for 225Ac-J591 (CONV01-α), a prostate-specific membrane antigen-targeted monoclonal antibody under investigation for the treatment of patients with advanced prostate cancer, announced Convergent Therapeutics, the developer
Maxone73
in
Advanced Prostate Cancer
29 days ago
Rising PCA - on ADT Holiday
Diagnosed Stage 4 oligometastatic (low volume) PCA in 2021. Gleason 7, 4+3 . Completed RT and 18 months on ADT (Nubeqa) paused the ADT in September after PSA non detectable and a fresh set of scans showed no “evidence of disease”. Continued to do bloodwork quarterly and PSA remained at 0. Until
Diagnosed Stage 4 oligometastatic (low volume) PCA in 2021. Gleason 7, 4+3 . Completed RT and 18 months on ADT (Nubeqa) paused the ADT in September after PSA non detectable and a fresh set of scans showed no “evidence of disease”. Continued to do bloodwork quarterly and PSA remained at 0. Until
Kkash
in
Advanced Prostate Cancer
1 month ago
Confused
UPDATE: April 5, 2024 Yesterday was very disappointing as my husbands PSA increased again by 183 points, last month his PSA was 1546 and now it is 1730. All his other CBC results were good. His Alkaline Phosphatase increased 6 points, last month 127 and now 133 but still in range of 40-150. Questioned
UPDATE: April 5, 2024 Yesterday was very disappointing as my husbands PSA increased again by 183 points, last month his PSA was 1546 and now it is 1730. All his other CBC results were good. His Alkaline Phosphatase increased 6 points, last month 127 and now 133 but still in range of 40-150. Questioned
MsHope
in
Advanced Prostate Cancer
1 month ago
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Prostrate Removed, PSA increasing
Hello to all, Is there anyone who had their prostrate removed but PSA is increasing? Oncologist wants to try a new hormonal drug. Radiation was administered after surgery. PSA is increasing. We appreciate your feedback. P.S. Edited profile: “Last CAT Scan was November 2023 - Showed no metastases
Hello to all, Is there anyone who had their prostrate removed but PSA is increasing? Oncologist wants to try a new hormonal drug. Radiation was administered after surgery. PSA is increasing. We appreciate your feedback. P.S. Edited profile: “Last CAT Scan was November 2023 - Showed no metastases
BlessedParchy
in
Advanced Prostate Cancer
1 month ago
NX 1607 - phase 1 trial, will also recruit prostate cancer patients but not from the beginning
Also some prostate cancer patients will be included in the trial further down the road...let's just keep this in mind https://www.cancernetwork.com/view/trial-will-assess-nx-1607-safety-and-tolerability-in-advanced-malignancies
Also some prostate cancer patients will be included in the trial further down the road...let's just keep this in mind https://www.cancernetwork.com/view/trial-will-assess-nx-1607-safety-and-tolerability-in-advanced-malignancies
Maxone73
in
Advanced Prostate Cancer
5 months ago
Immunotherapy could surprise us: Columbia study about mCRPC patients
"Immunotherapy has been disappointing as a prostate cancer treatment, but a new Columbia study suggests that the powerful treatments have potential when the disease starts to spread." https://www.cuimc.columbia.edu/news/metastatic-prostate-cancer-immunotherapy-may-have-unexpected-potential
"Immunotherapy has been disappointing as a prostate cancer treatment, but a new Columbia study suggests that the powerful treatments have potential when the disease starts to spread." https://www.cuimc.columbia.edu/news/metastatic-prostate-cancer-immunotherapy-may-have-unexpected-potential
Maxone73
in
Advanced Prostate Cancer
5 months ago
PSMA PET SCAN AND PSA
I had a disagreement with my RO today and wonder if he is right. My last PSMA PET Scan in Dec 2023 showed no progression. End January onwards I have an on off pain in the left ribcage area with an increasing frequency. To recap....PT3bN1Mx, RP in 2019, IMRT 2020 and on ADT for 30 months, currently completed
I had a disagreement with my RO today and wonder if he is right. My last PSMA PET Scan in Dec 2023 showed no progression. End January onwards I have an on off pain in the left ribcage area with an increasing frequency. To recap....PT3bN1Mx, RP in 2019, IMRT 2020 and on ADT for 30 months, currently completed
Tally111
in
Advanced Prostate Cancer
1 month ago
Have not seen an answer to this question
Senior on abiraterone and prednisone due to metastatic cancer in lymph nodes…..wife and I still interested…….do not know if it will work but will I recharge the cancer and cause harm by using Viagra ?
Senior on abiraterone and prednisone due to metastatic cancer in lymph nodes…..wife and I still interested…….do not know if it will work but will I recharge the cancer and cause harm by using Viagra ?
Mbnm
in
Advanced Prostate Cancer
5 months ago
Final Pluvicto shot and things OK
I just had my 6th, and final, injection. Feeling well but everyone concerned with kidney function dropping -- hopefully transient and not an on-going trend, on the plus side this is the last time it has to deal with all that radioactive liquid. Chugging water and peeing like a champ! To review:
I just had my 6th, and final, injection. Feeling well but everyone concerned with kidney function dropping -- hopefully transient and not an on-going trend, on the plus side this is the last time it has to deal with all that radioactive liquid. Chugging water and peeing like a champ! To review:
Miccoman
in
Advanced Prostate Cancer
1 month ago
what is choline-avid prostate cancer
hi,I was dx in 2014 finished treatment in 2016 ht/rt psa is 0.04 so still ok except I now have severe osteoporosis for which I am having treatment, what I want to ask is does anyone take krill oil to help there joints, I have been reading on canceractive that krill oil is not good for prostate cancer
hi,I was dx in 2014 finished treatment in 2016 ht/rt psa is 0.04 so still ok except I now have severe osteoporosis for which I am having treatment, what I want to ask is does anyone take krill oil to help there joints, I have been reading on canceractive that krill oil is not good for prostate cancer
Radars
in
Advanced Prostate Cancer
1 month ago
severe neck pain
I’m a couple of months in on eligard,abiraterone and prednisone(5mg). Mercifully I’m relatively SE free at this point but know it’s early…..what I DO have after the first few weeks is a chronically stiff neck that makes it impossible to move my head to the right…..Wondering if anyone has ever heard of
I’m a couple of months in on eligard,abiraterone and prednisone(5mg). Mercifully I’m relatively SE free at this point but know it’s early…..what I DO have after the first few weeks is a chronically stiff neck that makes it impossible to move my head to the right…..Wondering if anyone has ever heard of
Tommyj2
in
Advanced Prostate Cancer
5 months ago
Time to PSA Nadir is related to progression-free-survival
This graph from Teoh (2014) plots the relationship between Time to PSA Nadir (months) versus Time to Progression (months) (i.e., Progression Free Survival). Cohort: ADT monotherapy (No RP or RT), all metastatic patients, median 74 y.o., GS = 8-10, N=419. A cubic spline curve fit matched the data points
This graph from Teoh (2014) plots the relationship between Time to PSA Nadir (months) versus Time to Progression (months) (i.e., Progression Free Survival). Cohort: ADT monotherapy (No RP or RT), all metastatic patients, median 74 y.o., GS = 8-10, N=419. A cubic spline curve fit matched the data points
janebob99
in
Advanced Prostate Cancer
1 month ago
Abiraterone seems to be working
An update on my situation. To review, I now appear to be castrate resistant after about 6 1/2 years of being castrate sensitive. My MO put me on Abiraterone, along the existing Lupron. I had my MO appt and my PSA has fallen from 4.5 to 2 after about 7 weeks on Abi. This is my second iteration with Abi
An update on my situation. To review, I now appear to be castrate resistant after about 6 1/2 years of being castrate sensitive. My MO put me on Abiraterone, along the existing Lupron. I had my MO appt and my PSA has fallen from 4.5 to 2 after about 7 weeks on Abi. This is my second iteration with Abi
fireandice123
in
Advanced Prostate Cancer
1 month ago
20,000 soon. Celebrate the high quality of support and Reflect on the state of prostate cancer
Soon, there will be 20,000 members in our Malecare Advanced Prostate Cancer community. What does reaching this milestone tell us about the state of prostate cancer treatments and therapies? What does it tell us about Malecare and the 19,999 people who preceded the 20,000th?
Soon, there will be 20,000 members in our Malecare Advanced Prostate Cancer community. What does reaching this milestone tell us about the state of prostate cancer treatments and therapies? What does it tell us about Malecare and the 19,999 people who preceded the 20,000th?
Darryl
Partner
in
Advanced Prostate Cancer
5 months ago
Olaparib for Metastatic Castration-Resistant Prostate Cancer With BRCA1 and/or BRCA2 Alterations
I know these results have been known for a while but me being germline and somatic BRCA 2, I thought it would be important to post this for those warriors with this condition. TAKE-HOME MESSAGE The phase III PROfound trial showed that patients with metastatic castration-resistant prostate cancer
I know these results have been known for a while but me being germline and somatic BRCA 2, I thought it would be important to post this for those warriors with this condition. TAKE-HOME MESSAGE The phase III PROfound trial showed that patients with metastatic castration-resistant prostate cancer
Balsam01
in
Advanced Prostate Cancer
5 months ago
3year Updates w/PSA Graph
Hi Everyone, I'd like to report my 3 year journey. Initial PSA 27 in 6/20. Diagnosed w/PC 10/20. Gleason score is 3+4 (high-risk). My T-stage is T2a/T2b. CT Scan showed no lymph node & Bone Scan showed some indication of met. PSMA/PET in 1/12/21 showed no met outside. Started ADT (Lupron
Hi Everyone, I'd like to report my 3 year journey. Initial PSA 27 in 6/20. Diagnosed w/PC 10/20. Gleason score is 3+4 (high-risk). My T-stage is T2a/T2b. CT Scan showed no lymph node & Bone Scan showed some indication of met. PSMA/PET in 1/12/21 showed no met outside. Started ADT (Lupron
brucesam
in
Advanced Prostate Cancer
1 month ago
Laparoscopic c section niche repair
Hello. Just after some advice if anyone has had a previous c section scar defect (niche) repaired via laparoscopy? Since TTC my second child (started IVF again in August last year) I’ve had a miscarriage (untested embryo) and two failed transfers (these were euploid embryos). I have a niche and my consultant
Hello. Just after some advice if anyone has had a previous c section scar defect (niche) repaired via laparoscopy? Since TTC my second child (started IVF again in August last year) I’ve had a miscarriage (untested embryo) and two failed transfers (these were euploid embryos). I have a niche and my consultant
Aftertherain1
in
Fertility Network UK
8 months ago
Concern about having more radiation to prostate after 43 external beam treatments 15 years ago
15 years ago my husband had 43 radiation treatments after PSA reached 50 & his 3rd biopsy showed 1 core to have cancer., Gleason was 3-3. He has had Lupron injections since then. He was on 250mg of Zytiga with food and 5 mg Prednisone for 3 years until a year ago because PSA was creeping up & he was
15 years ago my husband had 43 radiation treatments after PSA reached 50 & his 3rd biopsy showed 1 core to have cancer., Gleason was 3-3. He has had Lupron injections since then. He was on 250mg of Zytiga with food and 5 mg Prednisone for 3 years until a year ago because PSA was creeping up & he was
Pickleball38
in
Advanced Prostate Cancer
1 month ago
Meeting with our oncologist for castrate resistance metastatic prostate cancer
We met with my Dad's MO yesterday. (Diagnosed 10/22 with advanced metastatic cancer, became castrate resistant about a year ago.) He shared that the Xtandi is still blocking some cancer growth, but not all of it. His PSA is 2.8 (currently doubling every four weeks.) His PetScan shows some growth (
We met with my Dad's MO yesterday. (Diagnosed 10/22 with advanced metastatic cancer, became castrate resistant about a year ago.) He shared that the Xtandi is still blocking some cancer growth, but not all of it. His PSA is 2.8 (currently doubling every four weeks.) His PetScan shows some growth (
lgutman
in
Advanced Prostate Cancer
1 month ago
Xtandi worked great
After radiation to prostate bed and to one pelvic metastasis, I was on xtandi and Lupton for three years and now have been on "vacation " for a year with PSA of 0.02 and testosterone at 4. No meds at all for last11 months!Had a heart attack in May '23 (which I attribute to covid shots) , doctors told
After radiation to prostate bed and to one pelvic metastasis, I was on xtandi and Lupton for three years and now have been on "vacation " for a year with PSA of 0.02 and testosterone at 4. No meds at all for last11 months!Had a heart attack in May '23 (which I attribute to covid shots) , doctors told
JAK2243
in
Advanced Prostate Cancer
1 month ago
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