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Know your Biomarker … Know Your Mutation
KRAS mutation in colorectal cancer is an abnormal change in the KRAS gene, which is involved in controlling cell growth and survival. 40% of CRC has a KRAS mutation. There are more than 25 ongoing clinical trials studying treatments for KRAS-mutated colorectal cancer. Learn more about the KRAS biomarker
KRAS mutation in colorectal cancer is an abnormal change in the KRAS gene, which is involved in controlling cell growth and survival. 40% of CRC has a KRAS mutation. There are more than 25 ongoing clinical trials studying treatments for KRAS-mutated colorectal cancer. Learn more about the KRAS biomarker
GCCA-Survivor
Administrator
in
Colon Cancer Connected
4 months ago
Combine standard care with alternative care
The University of Maryland reported two cases of terminated PCs by combining standard care treatment with an alternative treatment. By reducing the PSAs to less than 3, the clioquinol + zinc killed more cancer than testosterone could renew, therefore termination. My PSA in three months went from 58
The University of Maryland reported two cases of terminated PCs by combining standard care treatment with an alternative treatment. By reducing the PSAs to less than 3, the clioquinol + zinc killed more cancer than testosterone could renew, therefore termination. My PSA in three months went from 58
agnut
in
Fight Prostate Cancer
6 months ago
Swallowing difficulties 5 months post-op
Hi everyone. I’m 46 and had keyhole oesohagectomy surgery 5 months ago for T3N1M0 adenocarcinoma. I’ve recovered really well in most ways. No reflux and sleeping well. I’ve gained 2 stone (12.7kg) since my post-op weight (having lost 4 stone since my symptoms began) and I feel fit and healthy BUT I
Hi everyone. I’m 46 and had keyhole oesohagectomy surgery 5 months ago for T3N1M0 adenocarcinoma. I’ve recovered really well in most ways. No reflux and sleeping well. I’ve gained 2 stone (12.7kg) since my post-op weight (having lost 4 stone since my symptoms began) and I feel fit and healthy BUT I
ScottishLondoner
in
Oesophageal & Gastric Cancer
6 months ago
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Immune Responses + Autoimmune Myelofibrosis
There were some posts a few weeks ago on adverse immune responses after vaccination for people using interferons. I had this experience while transitioning form HU to Peg, firstly with a covid jab last December and secondly with the first of the Shingrix jabs in March, which triggered, at the very least
There were some posts a few weeks ago on adverse immune responses after vaccination for people using interferons. I had this experience while transitioning form HU to Peg, firstly with a covid jab last December and secondly with the first of the Shingrix jabs in March, which triggered, at the very least
LongETinUS
in
MPN Voice
6 months ago
Bleeding when opening the bowels
does anyone else get this? I had to have an emergency appointment today as I went to the toilet and when I opened my bowels and looked in the toilet, the water and bowl were full of blood! I had confirmed stage 2 endo on my bladder and ovary, I’ve also had mumtiple colonoscopies, sigmoidoscopies, endoscopies
does anyone else get this? I had to have an emergency appointment today as I went to the toilet and when I opened my bowels and looked in the toilet, the water and bowl were full of blood! I had confirmed stage 2 endo on my bladder and ovary, I’ve also had mumtiple colonoscopies, sigmoidoscopies, endoscopies
nikogirl18
in
Endometriosis UK
4 months ago
24 Year Old Female
GRAPHIC PICTURE - BLOOD 🩸 hello, would love some advice. I’ve been having rectal bleeding for a year now, but recently it got worse and it’s been filling up the toilet. I’ve ignored it because I’ve had no other pain anywhere and I’ve felt relatively normal, but revelry I’ve had stomach pains and major
GRAPHIC PICTURE - BLOOD 🩸 hello, would love some advice. I’ve been having rectal bleeding for a year now, but recently it got worse and it’s been filling up the toilet. I’ve ignored it because I’ve had no other pain anywhere and I’ve felt relatively normal, but revelry I’ve had stomach pains and major
muffinismycatsname
in
Colon Cancer Connected
6 months ago
Low Volume Low PSA Metastatic PC.
When my Oncologist refers to Low volume, Low PSA Oglimetastic PC, what is he saying about my disease? I’ve been oo Abiraterone followed by Xtandi with Lupron every 3 months and Zometa every 6.
When my Oncologist refers to Low volume, Low PSA Oglimetastic PC, what is he saying about my disease? I’ve been oo Abiraterone followed by Xtandi with Lupron every 3 months and Zometa every 6.
NDJIM
in
Advanced Prostate Cancer
6 months ago
preventative mastectomy
Good afternoon, Not been on here for a while , I was wondering if anyone here with the BRCA gene has had a preventative mastectomy, if so how was your experience? Did you have any regrets? We’re you happy with the surgery? What type ,if any reconstruction did you have? I was diagnosed with BRCA2 in
Good afternoon, Not been on here for a while , I was wondering if anyone here with the BRCA gene has had a preventative mastectomy, if so how was your experience? Did you have any regrets? We’re you happy with the surgery? What type ,if any reconstruction did you have? I was diagnosed with BRCA2 in
March2017
in
My Ovacome
6 months ago
Immunotherapy
Having had a lobectomy a few years ago on right lung, I now have 2 opacities on lower left lung. As there had only been one lesion seen on lower left lung I was offered radiotherapy. After last scan which showed another lesion adjacent to the first, I am told that 'radiotherapy is off the table'. At
Having had a lobectomy a few years ago on right lung, I now have 2 opacities on lower left lung. As there had only been one lesion seen on lower left lung I was offered radiotherapy. After last scan which showed another lesion adjacent to the first, I am told that 'radiotherapy is off the table'. At
ferntreegully
in
The Roy Castle Lung Cancer Foundation
1 year ago
Arx517 updates about the trial for metastatic castration resistant prostate cancer
”Following completion of the 21-day observation period at 3.4 mg/kg (Cohort 9), no dose limiting toxicities (DLTs) or serious adverse events (SAEs) were observed Two patients in Cohort 9 experienced rapid PSA reduction at three weeks post-treatment following the first ARX517 dose” https://www.biospace.com
”Following completion of the 21-day observation period at 3.4 mg/kg (Cohort 9), no dose limiting toxicities (DLTs) or serious adverse events (SAEs) were observed Two patients in Cohort 9 experienced rapid PSA reduction at three weeks post-treatment following the first ARX517 dose” https://www.biospace.com
Maxone73
in
Advanced Prostate Cancer
6 months ago
First Patient Receives Antibody-based Prostate Cancer Treatment TLX591 for mCRPC
“previous data from a phase 2 trial evaluating TLX591 reflected 42.3 months for overall survival” https://www.curetoday.com/view/first-patient-receives-antibody-based-prostate-cancer-treatment-tlx591
“previous data from a phase 2 trial evaluating TLX591 reflected 42.3 months for overall survival” https://www.curetoday.com/view/first-patient-receives-antibody-based-prostate-cancer-treatment-tlx591
Maxone73
in
Advanced Prostate Cancer
6 months ago
And more ASCO GU 2024 phase 3 trial
Data will be presented at ASCO GU 2024 but looks promising "In combination with immunotherapy, Cabometyx is delivering long-term survival benefits today for people living with renal cell carcinoma worldwide, while also showcasing future potential in metastatic castration-resistant prostate cancer, an
Data will be presented at ASCO GU 2024 but looks promising "In combination with immunotherapy, Cabometyx is delivering long-term survival benefits today for people living with renal cell carcinoma worldwide, while also showcasing future potential in metastatic castration-resistant prostate cancer, an
Maxone73
in
Advanced Prostate Cancer
4 months ago
4 months post TT
hi everyone! I am writing because I wanted to see if anybody had similar experiences. I am four months post total thyroidectomy, and in the first month or so I didn’t really feel many or any symptoms. Now in the past two months, I feel like I am feeling more symptoms of hypothyroidism than I did, in
hi everyone! I am writing because I wanted to see if anybody had similar experiences. I am four months post total thyroidectomy, and in the first month or so I didn’t really feel many or any symptoms. Now in the past two months, I feel like I am feeling more symptoms of hypothyroidism than I did, in
Rfranzoni
in
Thyroid UK
6 months ago
Zytiga after failing nubeqa ?
Has anyone had any luck with Zytiga after nubeqa fails to hold down PSA? I have been mCRPC for a few years now and Im curious if there is any chance Zytiga would work after the combination of Orgovyx/Nubeqa failed. I had some good results years ago when I was still nmCRPC with Firmagon/Xtandi, but had
Has anyone had any luck with Zytiga after nubeqa fails to hold down PSA? I have been mCRPC for a few years now and Im curious if there is any chance Zytiga would work after the combination of Orgovyx/Nubeqa failed. I had some good results years ago when I was still nmCRPC with Firmagon/Xtandi, but had
joeguy
in
Advanced Prostate Cancer
6 months ago
Third recurrence, very worried.
I've just started Caelyx ,after my CA125 went up , always a good predictor for me. CT showed a 3cm tumour pressing on my ureter so I needed a stent to release pressure on my kidney. I had ablation on a liver tumour in August this year in the hope that I might get a break!. A CT in Sept showed me to be
I've just started Caelyx ,after my CA125 went up , always a good predictor for me. CT showed a 3cm tumour pressing on my ureter so I needed a stent to release pressure on my kidney. I had ablation on a liver tumour in August this year in the hope that I might get a break!. A CT in Sept showed me to be
Seedlings
in
My Ovacome
6 months ago
Orchidectomy vs ADT
For anyone who had the bilateral orchidectomy, I would like some advice for my husband. When was it done? Before or after BCR occurred? What are the side effects? Do you take any other ADT meds after? How is your QOL and is there anything you'd do differently. He had RP in Dec 2021. No other treatment
For anyone who had the bilateral orchidectomy, I would like some advice for my husband. When was it done? Before or after BCR occurred? What are the side effects? Do you take any other ADT meds after? How is your QOL and is there anything you'd do differently. He had RP in Dec 2021. No other treatment
tn12
in
Advanced Prostate Cancer
4 months ago
chemo break
my lovely mum just finished 6 rounds of carbo caelyx after recurrring 11 months from frontline. Her mid treatment scan showed a reduction in all tumours and post 6 a further reduction. She has a cold currently and ca125 is 113. Her oncologist said he’s very happy with her and they will go back to 3
my lovely mum just finished 6 rounds of carbo caelyx after recurrring 11 months from frontline. Her mid treatment scan showed a reduction in all tumours and post 6 a further reduction. She has a cold currently and ca125 is 113. Her oncologist said he’s very happy with her and they will go back to 3
Worrieddaughter95
in
My Ovacome
6 months ago
Bleeding Prostate
My prostate has been bleeding for the past 5 months. It wasn't a real problem until I started passing sizeable clots and had difficulty starting my flow. Urologist has suggested TURP or radiation after cystoscopy. He highly recommended TURP. Anyone else have this wonderful experience?
My prostate has been bleeding for the past 5 months. It wasn't a real problem until I started passing sizeable clots and had difficulty starting my flow. Urologist has suggested TURP or radiation after cystoscopy. He highly recommended TURP. Anyone else have this wonderful experience?
Clays711
in
Advanced Prostate Cancer
6 months ago
PSA rising
Hi to the most incredible and informative group. I have been on hormone injections every 3 months. Abiraterone 500 mg with food and 5mg pred. psa 0.8 has increased to 0.17 in 2 months. questions. Should I up Abiraterone to 1000mg to help lower psa or am I on the downward slope now? Diagnosed 2019
Hi to the most incredible and informative group. I have been on hormone injections every 3 months. Abiraterone 500 mg with food and 5mg pred. psa 0.8 has increased to 0.17 in 2 months. questions. Should I up Abiraterone to 1000mg to help lower psa or am I on the downward slope now? Diagnosed 2019
Lion321
in
Advanced Prostate Cancer
6 months ago
Side Effects at 1 year
Approaching my 1 year date of treatment. Followed the Peace-1 trial Lupron (3 month injection) + 250mg Abiraterone/ 10mg Prednisone + 6 cycles Docetaxel + Xgeva 28 days/ adjusted to 90 days I adopte the Mediterranean diet and have used Pickleball (4.5 player) to exercise 6 days per week. Used dumbbells
Approaching my 1 year date of treatment. Followed the Peace-1 trial Lupron (3 month injection) + 250mg Abiraterone/ 10mg Prednisone + 6 cycles Docetaxel + Xgeva 28 days/ adjusted to 90 days I adopte the Mediterranean diet and have used Pickleball (4.5 player) to exercise 6 days per week. Used dumbbells
TMcgee
in
Advanced Prostate Cancer
6 months ago
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