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Immediate-Release Versus Controlled-Released Carbidopa-Levodopa
More from the
Sinemet
CR
label: "In healthy elderly subjects (56-67 years old) the mean time-to-peak concentration of levodopa after a single dose of
Sinemet
CR
50-200 was about 2 hours as compared to 0.5 hours after standard SINEMET.
More from the
Sinemet
CR
label: "In healthy elderly subjects (56-67 years old) the mean time-to-peak concentration of levodopa after a single dose of
Sinemet
CR
50-200 was about 2 hours as compared to 0.5 hours after standard SINEMET.
park_bear
in
Cure Parkinson's
3 years ago
PTT FUS 4 months later
I had today my 3 months phone consultation with Prof. J. (one month later). He saw my videos, with and without levodopa e said that i was "very close to normal". Indeed, sometimes i feel close to normal, not everyday, not every hour, but especially in the morning i feel like that. I am able to run again
I had today my 3 months phone consultation with Prof. J. (one month later). He saw my videos, with and without levodopa e said that i was "very close to normal". Indeed, sometimes i feel close to normal, not everyday, not every hour, but especially in the morning i feel like that. I am able to run again
Markbit
in
Cure Parkinson's
3 years ago
Much of What We Have to Fear Is Fear Itself?
During his first inaugural address in 1933, American president Franklin D. Roosevelt famously said, "All we have to fear is fear itself." I wish it were that simple when it comes to Parkinson's Disease, but as I approach the three year anniversary of my diagnosis, I have come to believe, at least at
During his first inaugural address in 1933, American president Franklin D. Roosevelt famously said, "All we have to fear is fear itself." I wish it were that simple when it comes to Parkinson's Disease, but as I approach the three year anniversary of my diagnosis, I have come to believe, at least at
jimcaster
in
Cure Parkinson's
3 years ago
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Ongentys this medication WORKS!
Prior to Ongentys I took 300 mg
Sinemet
(50-200 mg ER) and (25-100 mg
CR
) every 3 hours 24 /7 or 8 X per day. I cut that back to 200 mg (1/2 tab 50-200 mg ER) and one tab 25-100 mg CR. Basically from 2400 mg to 1600. I'm usually in bed by 830 pm. Good sleep (5 hours+) is a rarity for us PWP.
Prior to Ongentys I took 300 mg
Sinemet
(50-200 mg ER) and (25-100 mg
CR
) every 3 hours 24 /7 or 8 X per day. I cut that back to 200 mg (1/2 tab 50-200 mg ER) and one tab 25-100 mg CR. Basically from 2400 mg to 1600. I'm usually in bed by 830 pm. Good sleep (5 hours+) is a rarity for us PWP.
Isthistheone
in
Cure Parkinson's
3 years ago
Is this progression normal
My husband, diagnosed 2015, is really struggling. He feels rough all the time. Main symptoms are shuffling, stoop (causing back ache), balance, slowness and lack of energy so exercise is very limited. On Sinemet 3 hourly, Rasagiline 1mg and Madopar 62.5 daily + Neupro patch 4mg. Nothing new seems to
My husband, diagnosed 2015, is really struggling. He feels rough all the time. Main symptoms are shuffling, stoop (causing back ache), balance, slowness and lack of energy so exercise is very limited. On Sinemet 3 hourly, Rasagiline 1mg and Madopar 62.5 daily + Neupro patch 4mg. Nothing new seems to
Abinat58
in
Cure Parkinson's
3 years ago
Sinemet intake blocked by Proteins
I was diagnosed in 1992 and have had DBS surgery. At 73, I am actually quite healthy. My question deals with protein intake due to Sinemet being blocked by animal and even quite a few plant proteins, namely amino acid foods. Are the other Parkinson drugs also sensitive to proteins? Has anyone else
I was diagnosed in 1992 and have had DBS surgery. At 73, I am actually quite healthy. My question deals with protein intake due to Sinemet being blocked by animal and even quite a few plant proteins, namely amino acid foods. Are the other Parkinson drugs also sensitive to proteins? Has anyone else
annmariebaird
in
Cure Parkinson's
3 years ago
Failing many meds over the years.
I have failed so many meds over the many years I’ve had RA. Very seldom for one to last even a year. So much so that my doctor is going back and we are trying some over again. Well today he said he was gonna put me on Kineret. It’s a once a day shot. He are you ok giving yourself an injection a day
I have failed so many meds over the many years I’ve had RA. Very seldom for one to last even a year. So much so that my doctor is going back and we are trying some over again. Well today he said he was gonna put me on Kineret. It’s a once a day shot. He are you ok giving yourself an injection a day
precious123
in
NRAS
3 years ago
Swollowing
I'm 60 yo diagnosed with PD 10 years ago I can honestly say my symptoms have not changed much recently diagnosed with generalized anxiety disorder and have infrequent moments where I forget how to swollow is it PD GAD or just age related usually only last a few seconds and if I think about it it
I'm 60 yo diagnosed with PD 10 years ago I can honestly say my symptoms have not changed much recently diagnosed with generalized anxiety disorder and have infrequent moments where I forget how to swollow is it PD GAD or just age related usually only last a few seconds and if I think about it it
Boomercd
in
Cure Parkinson's
3 years ago
feeling fatuged
does anyone have off days with parkinsons? in the mornings my uncle before his tablets manages to have a shower get dressed by himself walk unaided and feels strong. then he feels washed out and rough afterwards until he's able to regain his strength again once his sinemet has kicked in. does anyone
does anyone have off days with parkinsons? in the mornings my uncle before his tablets manages to have a shower get dressed by himself walk unaided and feels strong. then he feels washed out and rough afterwards until he's able to regain his strength again once his sinemet has kicked in. does anyone
sjmorris31
in
Cure Parkinson's
3 years ago
Hallucinations
Can anyone give me advice on hallucinations. My partner just started on 100/25 c/l 3 times a day and has been hallucinating intermittently ever since... moreso at night. They aren’t troubling hallucinations so he’s coping fine but I worry that they’ll become more difficult to distinguish from reality
Can anyone give me advice on hallucinations. My partner just started on 100/25 c/l 3 times a day and has been hallucinating intermittently ever since... moreso at night. They aren’t troubling hallucinations so he’s coping fine but I worry that they’ll become more difficult to distinguish from reality
Scrudgie
in
Cure Parkinson's
3 years ago
Sinemet Slow-release Hard Candy
Has anyone tried making a home-made slow-release levodopa lozenge or hard candy that you can suck on and have constant levels of dopamine in your system?
Has anyone tried making a home-made slow-release levodopa lozenge or hard candy that you can suck on and have constant levels of dopamine in your system?
DeanGreen
in
Cure Parkinson's
3 years ago
How does PD lead to leg edema?
I posted a few days ago but no answers. Both legs are swollen due to pitting edema. I have slowness/weakness in my left leg. A few days ago I noticed swelling and assumed it was just in my left leg. But this photo shows swelling in both legs. [i] I started Sinemet last year. Since then
I posted a few days ago but no answers. Both legs are swollen due to pitting edema. I have slowness/weakness in my left leg. A few days ago I noticed swelling and assumed it was just in my left leg. But this photo shows swelling in both legs. [i] I started Sinemet last year. Since then
kaypeeoh
in
Cure Parkinson's
3 years ago
changing medication
hello. my uncle is 73 he has had parkinsons for nearly 10 years. he started antacapone 3 weeks ago with sinemet. this threw him and made dyskinisia worse. now he's stopped the antacapone and just takes the sinemet. however when it wear off he shakes terribly. is this normal? he doesn't seem to cope very
hello. my uncle is 73 he has had parkinsons for nearly 10 years. he started antacapone 3 weeks ago with sinemet. this threw him and made dyskinisia worse. now he's stopped the antacapone and just takes the sinemet. however when it wear off he shakes terribly. is this normal? he doesn't seem to cope very
sjmorris31
in
Cure Parkinson's
3 years ago
Parkinson's tremor both sides now
Hello, I've only ever had left side tremor mostly my hand and lower arm. My tremor is now right side too eminating from my core down both arms into my hands. Most uncomfortable feeling ever. My core shakes. Pandemic lockdown has lessened my movement and eliminated my ability to have physical therapy
Hello, I've only ever had left side tremor mostly my hand and lower arm. My tremor is now right side too eminating from my core down both arms into my hands. Most uncomfortable feeling ever. My core shakes. Pandemic lockdown has lessened my movement and eliminated my ability to have physical therapy
Jenzo
in
Cure Parkinson's
3 years ago
Why did adding carbidopa to mucuna make me sick?
I've been using mucuna (Barlowe's Brown 40%) since March 11. It's been working pretty well, but I wanted to see if adding carbidopa would make it more effective. I had some that my neurologist prescribed when I was trying to take Sinemet, so I took half of a tablet (12.5 mg) with my 1/8 teaspoon of mucuna
I've been using mucuna (Barlowe's Brown 40%) since March 11. It's been working pretty well, but I wanted to see if adding carbidopa would make it more effective. I had some that my neurologist prescribed when I was trying to take Sinemet, so I took half of a tablet (12.5 mg) with my 1/8 teaspoon of mucuna
1LittleWillow
in
Cure Parkinson's
3 years ago
Is edema a side effect of RYTARY?
[i]I noticed some edema in my foot and ankles when first trying medications for PD. I tried Sinemet but also tried amantadine and ropinerole. I never knew which medication caused the edema. Now I'm on Rytary alone and edema is back. I wore shorts today and both the neuro and my wife noticed
[i]I noticed some edema in my foot and ankles when first trying medications for PD. I tried Sinemet but also tried amantadine and ropinerole. I never knew which medication caused the edema. Now I'm on Rytary alone and edema is back. I wore shorts today and both the neuro and my wife noticed
kaypeeoh
in
Cure Parkinson's
3 years ago
Ho bisogno di aiuto per effetti collaterali del sinemet
Salve a tutti, ho un problema e ho bisogno di un vostro consiglio, prendo 1 pasticca di sinemet a rilascio modificato 100/25 due volte al giorno. Da qualche tempo la mattina, ho la saliva scura, con delle tracce di sangue. Mi potete dire se c'è un farmaco che corrisponde al sinemet, per avere levodopa
Salve a tutti, ho un problema e ho bisogno di un vostro consiglio, prendo 1 pasticca di sinemet a rilascio modificato 100/25 due volte al giorno. Da qualche tempo la mattina, ho la saliva scura, con delle tracce di sangue. Mi potete dire se c'è un farmaco che corrisponde al sinemet, per avere levodopa
Delfino
in
Cure Parkinson's
3 years ago
Does anyone have experience taking a "drug holiday" from sinemet or any other levodopa drug? For how long? Was it successful? Did it reset?
Levodopa drug holiday?
Levodopa drug holiday?
macandcheese
in
Cure Parkinson's
3 years ago
Neupro - 1st day on...working I think...
So this is interesting. I didn’t take my Sinemet this morning and thank God I didn’t because the constipation I’ve had from it has been so awful and actually gave me an impacted bowel so I did the next best thing and took a lovely suppository and that worked incredible magic needless to say. Sorry for
So this is interesting. I didn’t take my Sinemet this morning and thank God I didn’t because the constipation I’ve had from it has been so awful and actually gave me an impacted bowel so I did the next best thing and took a lovely suppository and that worked incredible magic needless to say. Sorry for
MissRita
in
Cure Parkinson's
3 years ago
Sinemet to Mirapex to Sinemet
Have you transitioned from Sinemet to Mirapex and then back to Sinemet?
Have you transitioned from Sinemet to Mirapex and then back to Sinemet?
timosky43
in
Restless Legs Syndrome
3 years ago
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