I've been using this med for 6 months, with very positive results. I posted on this before and was surprised on the apparent low interest. Back in October 2020 I complained to my Neuro, my Sinemet was wearing off suddenly. I went from being totally functional to frozen in seconds. Also my dosage regimen was wearing off in less than 3 hours, sometimes in 2 hours. He prescribed Ongentys. I did my DD and was satisfied the benefits far outweighed the risks. I don't like additions to my meds, there are usually/always unpleasant side effects.
Ongentys is a COMT inhibitor. I'll leave the mechanisms for how it works to my learned colleagues. Ongentys allows more L-dopa into the brain by inhibiting an enzyme that likes to dine on L-dopa. I take one capsule 50 mg at bedtime on an empty stomach. I also take one capsule (137 mg) of Gocovri for dyskenesia, a side effect of Ongentys. I was on Selegiline 5 mg tablet daily. Selegiline is a MAO inhibitor. Another enzyme that loves depleting L-dopa. I can say I don't think Selegiline was ever a benefit to me. Selegiline did give me serious constipation. I've been Selegiline free for 6 months and almost constipation free.
Prior to Ongentys I took 300 mg Sinemet (50-200 mg ER) and (25-100 mg CR) every 3 hours 24 /7 or 8 X per day. I cut that back to 200 mg (1/2 tab 50-200 mg ER) and one tab 25-100 mg CR. Basically from 2400 mg to 1600. I'm usually in bed by 830 pm. Good sleep (5 hours+) is a rarity for us PWP. When the stars align and I get good sleep, I skip my 11 pm and 2 am doses!!
Very happy with my results. No more freeze ups and brain fog substantially reduced.