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Median PFS for FCR treated CLL patients with IGHV-M was 14.6 years vs 4.2 years for patients with IGHV-UM. V+O and I+R look to be superior
An update of the long-term follow-up results from the original 300-patient FCR (fludarabine, cyclophosphamide, and rituximab) study initiated at MD Anderson in 1999,
Sustained remissions in CLL after frontline FCR treatment with very-long-term follow-up,
reports ~47% of patients with mutated IGHV
An update of the long-term follow-up results from the original 300-patient FCR (fludarabine, cyclophosphamide, and rituximab) study initiated at MD Anderson in 1999,
Sustained remissions in CLL after frontline FCR treatment with very-long-term follow-up,
reports ~47% of patients with mutated IGHV
AussieNeil
Partner
in
CLL Support
12 days ago
Anybody outside the range part 2.
Hello again, the original post from yesterday and some more information and questions underneath. Thanks again for all the help. Part 1 Good afternoon everybody hope this makes sense Is there anybody out there that needs to run outside the ranges in order to feel good? At
Hello again, the original post from yesterday and some more information and questions underneath. Thanks again for all the help. Part 1 Good afternoon everybody hope this makes sense Is there anybody out there that needs to run outside the ranges in order to feel good? At
Jimjamio
in
Thyroid UK
12 days ago
ICU Stay Neuro Challenges
Seeing if anyone has any insight. On May 16th my mom (62 years old) went to her cardiologist with chest pain. She did have afib for the last three year but she had that under control. When she went to her cardiologist on the 16th he sent her to the ER just because he was concerned with chest pains
Seeing if anyone has any insight. On May 16th my mom (62 years old) went to her cardiologist with chest pain. She did have afib for the last three year but she had that under control. When she went to her cardiologist on the 16th he sent her to the ER just because he was concerned with chest pains
Doglover276
in
ICUsteps
13 days ago
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Subcutaneous combination therapy improves ‘good on’ time in Parkinson’s
Primary analyses from this phase 3 clinical trial of the investigational, subcutaneous infusion of levodopa/carbidopa (LD/CD) (ND0612) showed that treatment in doses of up to 720 mg/90 mg per day, supplemented with oral levodopa provided almost 2 additional hours per day of “Good On” time without troublesome
Primary analyses from this phase 3 clinical trial of the investigational, subcutaneous infusion of levodopa/carbidopa (LD/CD) (ND0612) showed that treatment in doses of up to 720 mg/90 mg per day, supplemented with oral levodopa provided almost 2 additional hours per day of “Good On” time without troublesome
Farooqji
in
Cure Parkinson's
14 days ago
Med Trials - Tell me Your Experiences
We’re on the med journey that I’m sure so many of you know well. My son is 7.5 ASD/PDA, originally also diagnosed ADHD with lots of anxiety. He struggles big time with emotional regulation, aggression, following routines and demands. He’s extremely verbal and social but has a hard time making and keeping
We’re on the med journey that I’m sure so many of you know well. My son is 7.5 ASD/PDA, originally also diagnosed ADHD with lots of anxiety. He struggles big time with emotional regulation, aggression, following routines and demands. He’s extremely verbal and social but has a hard time making and keeping
STARTwHello
in
CHADD's ADHD Parents Together
14 days ago
PT and Biofeedback
hi everyone…….has anyone gotten substantial improvement from PT and biofeedback? I had CA 20 yrs ago and now having lots of GI problems. My GI specialist would like me to try this to see if I can get some improvements. Otherwise she’d like me to see a colorectal surgeon. I’ve called many places and no
hi everyone…….has anyone gotten substantial improvement from PT and biofeedback? I had CA 20 yrs ago and now having lots of GI problems. My GI specialist would like me to try this to see if I can get some improvements. Otherwise she’d like me to see a colorectal surgeon. I’ve called many places and no
JuneyandGracie
in
Pelvic Radiation Disease Association
15 days ago
My path to combination therapy
I was diagnosed with hypothyroidism about 25 years ago, in my mid-thirties. For almost 20 years, I took only Levothyroxine. I realise now that I was probably depressed for the whole period. Back in 2016, I decided to quit drinking alcohol. I wasn't an alcoholic, but I was drinking every day, and sometimes
I was diagnosed with hypothyroidism about 25 years ago, in my mid-thirties. For almost 20 years, I took only Levothyroxine. I realise now that I was probably depressed for the whole period. Back in 2016, I decided to quit drinking alcohol. I wasn't an alcoholic, but I was drinking every day, and sometimes
Morphiouso
in
Thyroid UK
15 days ago
Inflammatory Arthritis
Hello everyone, I was diagnosed with inflammatory arthritis this past October and the rheumatologist tried to put me on Methotroxate and I kindly declined after seeing all the negative reviews about it. I’m only 31 years old and have to get fluid drained off of my knee at least 1-2 times a year. Has
Hello everyone, I was diagnosed with inflammatory arthritis this past October and the rheumatologist tried to put me on Methotroxate and I kindly declined after seeing all the negative reviews about it. I’m only 31 years old and have to get fluid drained off of my knee at least 1-2 times a year. Has
rms3377
in
NRAS
15 days ago
New to the community
Hi there, I'm Weng , 57, from Singapore. Last year, I was told by my neurologist that I have PD. The news came when I was about to retire. My goal is stay off medication and continue living a normal life. I have made a lot of lifestyle change since that fateful day. Things I do to help myself: brisk
Hi there, I'm Weng , 57, from Singapore. Last year, I was told by my neurologist that I have PD. The news came when I was about to retire. My goal is stay off medication and continue living a normal life. I have made a lot of lifestyle change since that fateful day. Things I do to help myself: brisk
Weng888
in
Cure Parkinson's
17 days ago
Side Effects of Herceptin and Perjeta
I had 1.5 cm local, node negative breast cancer recurrence 3.3 years after my first breast cancer diagnosis. HER2+ PR+ ER+( triple positive). I opted not to have Chemo, but did have targeted therapy for the HER2+ cancer, Herceptin and Perjeta subcutaneous injections for a year. The worst constant side
I had 1.5 cm local, node negative breast cancer recurrence 3.3 years after my first breast cancer diagnosis. HER2+ PR+ ER+( triple positive). I opted not to have Chemo, but did have targeted therapy for the HER2+ cancer, Herceptin and Perjeta subcutaneous injections for a year. The worst constant side
Hidden
in
SHARE Breast Cancer Support
19 days ago
New drug approved in Europe for uncontrolled COPD.
Good news folks! I learnt today that there is a new drug out for uncontrolled COPD with evidence type 2 inflammation levels. This medication is called Dupixent and has been approved for use in Europe by the European Medicines Agency. Before you get too excited, of course this doesn't mean that
Good news folks! I learnt today that there is a new drug out for uncontrolled COPD with evidence type 2 inflammation levels. This medication is called Dupixent and has been approved for use in Europe by the European Medicines Agency. Before you get too excited, of course this doesn't mean that
PaulineHM
in
Lung Conditions Community Forum
19 days ago
New Drug on the near horizon.
Good news folks! I learnt today that there is a new drug out for uncontrolled COPD with evidence type 2 inflammation levels. This medication is called Dupixent and has been approved for use in Europe by the European Medicines Agency. Before you get too excited, of course this doesn't mean that it
Good news folks! I learnt today that there is a new drug out for uncontrolled COPD with evidence type 2 inflammation levels. This medication is called Dupixent and has been approved for use in Europe by the European Medicines Agency. Before you get too excited, of course this doesn't mean that it
PaulineHM
in
COPD Friends
19 days ago
New Clinical Trial Starting: A Study of AAV2-GDNF in Adults With Moderate Parkinson's Disease (REGENERATE-PD) (REGENERATE-PD)
Here is a link to the trial on clinicaltrials.gov https://clinicaltrials.gov/study/NCT06285643?term=REGENERATE-PD&rank=1 Below is an excerpt from a news article about the trial: A new Phase II trial, REGENERATE-PD, will study AB-1005, an adeno-associated virus 2 (AAV2) glial cell line-derived neurotrophic
Here is a link to the trial on clinicaltrials.gov https://clinicaltrials.gov/study/NCT06285643?term=REGENERATE-PD&rank=1 Below is an excerpt from a news article about the trial: A new Phase II trial, REGENERATE-PD, will study AB-1005, an adeno-associated virus 2 (AAV2) glial cell line-derived neurotrophic
Canddy
in
Cure Parkinson's
24 days ago
Update on FIL -Venetoclax as a Monotherapy, Pancytopenia and Myelodysplasia
Hi everyone I have been meaning to post an update for months but things have been changing so rapidly, every day would have been a different story. So we did get to see a specialist who did a BM biopsy and recommended Venetoclax as a Monotherapy as his BM was 50% CLL. We were told it wasn't chemo
Hi everyone I have been meaning to post an update for months but things have been changing so rapidly, every day would have been a different story. So we did get to see a specialist who did a BM biopsy and recommended Venetoclax as a Monotherapy as his BM was 50% CLL. We were told it wasn't chemo
JoeMcDote
in
CLL Support
26 days ago
My Body is giving up
Morning all just wanted to see if anyone can relate to some of the stuff I have going on and offer some form of advice! The struggle has been going on for 14 years but 5 years I had a laposcopt which found Endo and chocolate cyst which exploded during and caused complications anyway since then things
Morning all just wanted to see if anyone can relate to some of the stuff I have going on and offer some form of advice! The struggle has been going on for 14 years but 5 years I had a laposcopt which found Endo and chocolate cyst which exploded during and caused complications anyway since then things
SamDan201
in
Endometriosis UK
9 months ago
Help!
Hello everyone. 💙It's been six months since my mother had herpes encephalitis type 1, but she still can't stand up and is physically weak. I don't know if occupational therapy is useful or not? What should I do to improve her physical condition?
Hello everyone. 💙It's been six months since my mother had herpes encephalitis type 1, but she still can't stand up and is physically weak. I don't know if occupational therapy is useful or not? What should I do to improve her physical condition?
Ftmz
in
Encephalitis International
27 days ago
Newly diagnosed with HCC
I am a 78 year old retired educator who has battled GIST CANCER for 20 years. To my surprise, An HCC tumor was found in my liver in between two GIST tumors. in my June 5 MRI. The GIST tumors were shrinking out of site thanks to be taking Gleevec, a targeted therapy drug. My surgeon could not safely resect
I am a 78 year old retired educator who has battled GIST CANCER for 20 years. To my surprise, An HCC tumor was found in my liver in between two GIST tumors. in my June 5 MRI. The GIST tumors were shrinking out of site thanks to be taking Gleevec, a targeted therapy drug. My surgeon could not safely resect
Dachshund45
in
Blue Faery Liver Cancer
27 days ago
Any truth to Estrogen being out of the question for hypothyroidism?
I keep getting email adverts from Forefront Health. This week it is lots of terrifying statistics on how suspectable we are to breast cancer and other cancers. I didn't know we had an increased risk of breast cancer. They then go on to say we are almost always estrogen dominant and that we should
I keep getting email adverts from Forefront Health. This week it is lots of terrifying statistics on how suspectable we are to breast cancer and other cancers. I didn't know we had an increased risk of breast cancer. They then go on to say we are almost always estrogen dominant and that we should
dayoff
in
Thyroid UK
9 months ago
Tapering withdrawal
Morning all , I am currently tapering from 3mg to 2mg , my blood test inflammation ratings are normal , but I am having very sore muscle pain whilst tapering , I am assuming it may be withdrawal symptoms from prednisone as I have been on prednisone for over two years , but dr is thinking it may be
Morning all , I am currently tapering from 3mg to 2mg , my blood test inflammation ratings are normal , but I am having very sore muscle pain whilst tapering , I am assuming it may be withdrawal symptoms from prednisone as I have been on prednisone for over two years , but dr is thinking it may be
HorseyG
in
PMRGCAuk
9 months ago
Advice
Hi All, I have hearing loss in both ears and have tinnitus all the time. This is a difficult challenge for us all. The doctors just put you on betahistine or amitriptyline or alprazolam or any anti depressants they say it helps reduce tinnitus or improve blood flow to inner ear. This is the same
Hi All, I have hearing loss in both ears and have tinnitus all the time. This is a difficult challenge for us all. The doctors just put you on betahistine or amitriptyline or alprazolam or any anti depressants they say it helps reduce tinnitus or improve blood flow to inner ear. This is the same
CMRN11
in
Tinnitus UK
29 days ago
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