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CDK 12 mutation and Immunotherapy
Hi All, My PSA as is starting to rise on Arbi/Dexa. I have the CDK12 mutation which is apparently known to be a drug target or to predict sensitivity to Atezolizumab (Tecentriq PD-1 Checkpoint Inhibitor), hence there is open Immunotherapy trial called BoB (NCT03767075). I meet the trial doctor next
Hi All, My PSA as is starting to rise on Arbi/Dexa. I have the CDK12 mutation which is apparently known to be a drug target or to predict sensitivity to Atezolizumab (Tecentriq PD-1 Checkpoint Inhibitor), hence there is open Immunotherapy trial called BoB (NCT03767075). I meet the trial doctor next
MikeMartin
in
Advanced Prostate Cancer
5 months ago
Erectile dysfunction
Hi My first post, I think it is pretty obvious that many of us, me included, associate our self worth, status with our 'masculinity'. This may or may not be a good thing, but many, most men in fact consider themselves to be profoundly binary. They represent the '1' to a feminine '0'. When a man fails
Hi My first post, I think it is pretty obvious that many of us, me included, associate our self worth, status with our 'masculinity'. This may or may not be a good thing, but many, most men in fact consider themselves to be profoundly binary. They represent the '1' to a feminine '0'. When a man fails
Iro1
in
Sensitive Issues for Men
5 months ago
Do low PSA-producing cells still rely on testosterone to grow?
Am curious to know what the folks here know about this question. If higher PSA cells are driven to near extinction by ADT, and if only low-PSA producing cells survive, are the latter still dependent on testosterone for survival? If not, what do they depend on to grow?
Am curious to know what the folks here know about this question. If higher PSA cells are driven to near extinction by ADT, and if only low-PSA producing cells survive, are the latter still dependent on testosterone for survival? If not, what do they depend on to grow?
novatimo
in
Advanced Prostate Cancer
8 months ago
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Looking for advice for my newly diagnosed dad
Hello, I was wondering if you can offer some thoughts on my dad’s situation. He was diagnosed with prostate cancer in February after a week in hospital with urine retention. A Ct scan he had in hospital showed 2 small mets in pelvic area. He’s had a biopsy which showed Gleason 4 +5 and his PSA in hospital
Hello, I was wondering if you can offer some thoughts on my dad’s situation. He was diagnosed with prostate cancer in February after a week in hospital with urine retention. A Ct scan he had in hospital showed 2 small mets in pelvic area. He’s had a biopsy which showed Gleason 4 +5 and his PSA in hospital
Springsunshi
in
Advanced Prostate Cancer
2 months ago
Post SBRT Day 9 - 15
Continuing my reporting on my experience after 5 SBRT treatments with focal boost, Barrigel spacer, urethral steering to try and avoid GU side effects. I am 68, in good shape, one 4+3, one 3+3, Decipher .84, PSA 7.8, PSMA PET confined to prostate, 6 months Orgovyx. Flomax started with treatment and
Continuing my reporting on my experience after 5 SBRT treatments with focal boost, Barrigel spacer, urethral steering to try and avoid GU side effects. I am 68, in good shape, one 4+3, one 3+3, Decipher .84, PSA 7.8, PSMA PET confined to prostate, 6 months Orgovyx. Flomax started with treatment and
ToolBeltZia
in
Prostate Cancer Network
5 months ago
Sufficient Investigation?
My brother is a bit of an ostrich, over his prostate problems. He ignored his poor urinary flow for years, and despite my repeated advice which he ignored, he subsequently had to be admitted to the emergency department due to significant obstruction. His GFR had fallen dangerously to 10. He was in
My brother is a bit of an ostrich, over his prostate problems. He ignored his poor urinary flow for years, and despite my repeated advice which he ignored, he subsequently had to be admitted to the emergency department due to significant obstruction. His GFR had fallen dangerously to 10. He was in
Nordman
in
Advanced Prostate Cancer
6 months ago
Letting Go
If it is one thing that I have after almost 18 years of playing this game, it is a story or perhaps many stories. So Many chapters. What I am about to say may seem easy from the perspective of undetectable PSA and clear scans these past 10 years. I assure you that at the time there was nothing easy about
If it is one thing that I have after almost 18 years of playing this game, it is a story or perhaps many stories. So Many chapters. What I am about to say may seem easy from the perspective of undetectable PSA and clear scans these past 10 years. I assure you that at the time there was nothing easy about
Todd1963
in
Advanced Prostate Cancer
5 months ago
EMBARK Study: ADT vs Enzalutamide +/- ADT
Results of the EMBARK study was published this week (10/19/23) in NEJM. It compared high risk BCR PCa treated in 3 groups: Lupron ADT alone. Enzalutamide plus ADT. And Enzalutamide monotherapy. 5 year follow up for metastasis free survival. Results below. Interesting that Enza monotherapy (No ADT) was
Results of the EMBARK study was published this week (10/19/23) in NEJM. It compared high risk BCR PCa treated in 3 groups: Lupron ADT alone. Enzalutamide plus ADT. And Enzalutamide monotherapy. 5 year follow up for metastasis free survival. Results below. Interesting that Enza monotherapy (No ADT) was
MateoBeach
in
Advanced Prostate Cancer
8 months ago
EMBARK Study: Enzalutamide +/- ADT
Results of the EMBARK study was published this week (10/19/23) in NEJM. It compared high risk BCR PCa treated in 3 groups: Lupron ADT alone. Enzalutamide plus ADT. And Enzalutamide monotherapy. 5 year follow up for metastasis free survival. Results below. Interesting that Enza monotherapy (No ADT) was
Results of the EMBARK study was published this week (10/19/23) in NEJM. It compared high risk BCR PCa treated in 3 groups: Lupron ADT alone. Enzalutamide plus ADT. And Enzalutamide monotherapy. 5 year follow up for metastasis free survival. Results below. Interesting that Enza monotherapy (No ADT) was
MateoBeach
in
Fight Prostate Cancer
8 months ago
Same medicine, different brand?
Good evening. I take a calcium channel blocker called Vera-Til SR 120mg, also known as Verapamil however, this particular brand is currently out of stock and I have been given an alternative which is Half Securon SR. My GP has advised that I always stick to one brand (Vera-Til SR) and the pharmacist
Good evening. I take a calcium channel blocker called Vera-Til SR 120mg, also known as Verapamil however, this particular brand is currently out of stock and I have been given an alternative which is Half Securon SR. My GP has advised that I always stick to one brand (Vera-Til SR) and the pharmacist
Tos92
in
British Heart Foundation
1 year ago
time to reach undetectable PSA after prostate removal
All, I am nervous about my post RALP PSA results reaching an undetectable level and wondering if anything has been published in this matter. For context, I am 65 and was diagnosed G8 with ECE and elected to have surgery which occurred on June 23rd. The surgery pathology indicated clean margins and no
All, I am nervous about my post RALP PSA results reaching an undetectable level and wondering if anything has been published in this matter. For context, I am 65 and was diagnosed G8 with ECE and elected to have surgery which occurred on June 23rd. The surgery pathology indicated clean margins and no
PorscheKing
in
Prostate Cancer Network
10 months ago
Possible Cure
Hi, I was diagnosed initially 2 years ago as Stage 4 with mets to the bones. Low volume. Gleason 8-9, PSA less than 2 from the onset. I had radiation to the prostate only. After 2 years of Lupron/Zytiga, everything has shrunk or disappeared via PSMA PET. Everything has been good,(but with med
Hi, I was diagnosed initially 2 years ago as Stage 4 with mets to the bones. Low volume. Gleason 8-9, PSA less than 2 from the onset. I had radiation to the prostate only. After 2 years of Lupron/Zytiga, everything has shrunk or disappeared via PSMA PET. Everything has been good,(but with med
groth12345
in
Advanced Prostate Cancer
9 months ago
Surgical Castration ?
I have been on Eligard for two months. Prior to starting ADT my Triglycerides were 100 (May 2023). After only two months of Eligard they are thru the roof (495). Since I have metastatic PC they tell me that I will be on ADT for life. I am considering surgical orchiectomy since there are fewer metabolic
I have been on Eligard for two months. Prior to starting ADT my Triglycerides were 100 (May 2023). After only two months of Eligard they are thru the roof (495). Since I have metastatic PC they tell me that I will be on ADT for life. I am considering surgical orchiectomy since there are fewer metabolic
Bigmaristuff
in
Advanced Prostate Cancer
10 months ago
Would I be on thin ice if I tried adaptive ADT this soon?
After 6 weeks on Lupron and 9 days on abiraterone, my PSA was .1, and my testosterone was <1. This is within the criteria being used to start people on adaptive in this MCSPC Moffitt study with Jingsong Yang - (he says I can just follow the protocol without being in the study)https://pubmed.ncbi.nlm.nih.gov
After 6 weeks on Lupron and 9 days on abiraterone, my PSA was .1, and my testosterone was <1. This is within the criteria being used to start people on adaptive in this MCSPC Moffitt study with Jingsong Yang - (he says I can just follow the protocol without being in the study)https://pubmed.ncbi.nlm.nih.gov
jackwfrench
in
Advanced Prostate Cancer
8 months ago
Sleep while taking Xtandi and Adt
Hello everyone, I am sure that this has been discussed on here before, I was unable to find any post to answer my question . I am taking Xtandi ( aprox 16 months) Lupron, I had chemo. My latest PSA was less then <0.01. It has been there for over a year now. ( See my profile for my journey.) My
Hello everyone, I am sure that this has been discussed on here before, I was unable to find any post to answer my question . I am taking Xtandi ( aprox 16 months) Lupron, I had chemo. My latest PSA was less then <0.01. It has been there for over a year now. ( See my profile for my journey.) My
JD-guy
in
Advanced Prostate Cancer
8 months ago
Discontinue all antioxidant supplements on early signs of biochemical recurrence?
The latest literature appears to indicate a PSA as low as 0.03, regardless of the multi-result dynamics is a reliable very early confirmation of biochemical recurrence. Maybe it's arguable some rare cases may "slip through" and stabilize without further treatment but data from the latest studies is
The latest literature appears to indicate a PSA as low as 0.03, regardless of the multi-result dynamics is a reliable very early confirmation of biochemical recurrence. Maybe it's arguable some rare cases may "slip through" and stabilize without further treatment but data from the latest studies is
jazj
in
Advanced Prostate Cancer
5 months ago
Clinical Trial Dallas UT Southwestern
Will begin a Pfizer starting on Monday. I will post more later as it goes. We are adding a drug to Xtandi to treat solid tumors. I have been on and off Xtandi a few times. I am chemo naive. In the past had a very heavy tumor load and received 3 rounds of Lu-177 from Ishita Sen, Fortis health in Delhi
Will begin a Pfizer starting on Monday. I will post more later as it goes. We are adding a drug to Xtandi to treat solid tumors. I have been on and off Xtandi a few times. I am chemo naive. In the past had a very heavy tumor load and received 3 rounds of Lu-177 from Ishita Sen, Fortis health in Delhi
pilot52
in
Advanced Prostate Cancer
8 months ago
Confusing CT scan results
My PSA has been rising slowly after prostate removal two years ago. Was at zero months after and slowly rising at .02,.03. .05, .06. .09 and then .13. My doctor ordered CT and bone scans. Bone scan came back clear and then CT scan showed a few things in bones and a nonspecific mass outside the liver
My PSA has been rising slowly after prostate removal two years ago. Was at zero months after and slowly rising at .02,.03. .05, .06. .09 and then .13. My doctor ordered CT and bone scans. Bone scan came back clear and then CT scan showed a few things in bones and a nonspecific mass outside the liver
Jens99
in
Advanced Prostate Cancer
5 months ago
Keytruda - year 4
So I’m pretty much closing the book on my 4th year on Keytruda (pembroluzimab). I’ve recently completely my 33rd Pembro infusion. Keytruda was my Hail Mary after running through most other SOC. My PSA was rising while on chemo the second time when I found out I had the markers that made me eligible
So I’m pretty much closing the book on my 4th year on Keytruda (pembroluzimab). I’ve recently completely my 33rd Pembro infusion. Keytruda was my Hail Mary after running through most other SOC. My PSA was rising while on chemo the second time when I found out I had the markers that made me eligible
Chugach
in
Advanced Prostate Cancer
8 months ago
Zytiga ,xtandi or erleada
Kaiser MO plan says will add Zytiga ,xtandi or erleada Been on lupron 2 months, MO now adding zytiga. 2nd opinion from UCSF concurs. Any opinions why they choose Zytiga I have seen a recent study saying Xtandi or Erleada might be better. Doctor Familiarity, Side effects, keep something back in the
Kaiser MO plan says will add Zytiga ,xtandi or erleada Been on lupron 2 months, MO now adding zytiga. 2nd opinion from UCSF concurs. Any opinions why they choose Zytiga I have seen a recent study saying Xtandi or Erleada might be better. Doctor Familiarity, Side effects, keep something back in the
pj1121
in
Advanced Prostate Cancer
10 months ago
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