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Brain Fog or Dimentia?
Hey warriors! So how do you know if you have brain fog or the beginning of dementia? Is it possible to blame ADT and Zytiga? My husband has been on Ellegaard for five years and Zytiga for 2 1/2. Years, he seems to have a lot of memory issues lately, and I fear it’s only getting worse Any thoughts or
Hey warriors! So how do you know if you have brain fog or the beginning of dementia? Is it possible to blame ADT and Zytiga? My husband has been on Ellegaard for five years and Zytiga for 2 1/2. Years, he seems to have a lot of memory issues lately, and I fear it’s only getting worse Any thoughts or
Keeper70
in
Advanced Prostate Cancer
4 months ago
Seeking anyone familiar with aggressive small cell neuroendocrine prostate cancer and/or with lurbinectedin as 2nd line chemotherapy.
A needle biopsy Oct 15, 2023 revealed that at least some of my metastatic prostate cancer in a lymph node had mutated to an aggressive small cell neuroendocrine prostate cancer. (notable for CDK N1B, RB1, Tp53 mutations. MSS, TMB low) I had 4 cycles of carboplatin/etoposide chemotherapy, which ended
A needle biopsy Oct 15, 2023 revealed that at least some of my metastatic prostate cancer in a lymph node had mutated to an aggressive small cell neuroendocrine prostate cancer. (notable for CDK N1B, RB1, Tp53 mutations. MSS, TMB low) I had 4 cycles of carboplatin/etoposide chemotherapy, which ended
silver5
in
Advanced Prostate Cancer
4 months ago
Fatiqued and wiped out feeling
I started lupron injection 5 months ago and starting my second month on nubeqa. I am extremely fatiqued and feel wiped out all the time. No ambition to do anything. Climbing stairs is an efford have to force myself to get out of bed. Cannot sleep very well. When I get up it feels like I have not slept
I started lupron injection 5 months ago and starting my second month on nubeqa. I am extremely fatiqued and feel wiped out all the time. No ambition to do anything. Climbing stairs is an efford have to force myself to get out of bed. Cannot sleep very well. When I get up it feels like I have not slept
woppaginny
in
Advanced Prostate Cancer
4 months ago
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NUV-1511 drug-drug conjugate (DDC) to enter the clinical stage: phase 1
"Dosing the first patient with NUV-1511 marks a significant milestone for our proprietary DDC platform, from which we are developing potent oncology-focused chimeric small molecules designed to selectively deliver anti-cancer therapeutics to cancer cells, while mitigating effects on healthy non-target
"Dosing the first patient with NUV-1511 marks a significant milestone for our proprietary DDC platform, from which we are developing potent oncology-focused chimeric small molecules designed to selectively deliver anti-cancer therapeutics to cancer cells, while mitigating effects on healthy non-target
Maxone73
in
Advanced Prostate Cancer
4 months ago
Tri modality conclusion end of ADT nervous
A long journey.. Lutron , bicalutamide .. from start last year in June .. brachytherapy.. in October… 15 booster LiNac in Dec/Jan .. doctor ..in Japan said can stop hormone treatment but he sort of front loaded the ADT before radiation 5 months.My second opinion initially said to embrace adjuvant ADT
A long journey.. Lutron , bicalutamide .. from start last year in June .. brachytherapy.. in October… 15 booster LiNac in Dec/Jan .. doctor ..in Japan said can stop hormone treatment but he sort of front loaded the ADT before radiation 5 months.My second opinion initially said to embrace adjuvant ADT
Yokohama2023
in
Advanced Prostate Cancer
4 months ago
xtandi
Medicare denied coverage of this. My dad needs it badly. Cancer in his spine growing. Starting to affect his ability to walk more and more everyday. We have spine pain management apt tmrw. Meet with radiology on Friday. Hopefully the can help him asap.
Medicare denied coverage of this. My dad needs it badly. Cancer in his spine growing. Starting to affect his ability to walk more and more everyday. We have spine pain management apt tmrw. Meet with radiology on Friday. Hopefully the can help him asap.
Hereformydad2022
in
Advanced Prostate Cancer
4 months ago
rising PSA
My PSA started rising after 6 years of being undetectable. July 2023 , PSA 0.10 and July 2024 PSA 0.70 . I had a PSMA pet scan when my PSA hit 0.30 in November 2023 , scan did not show any cancer. I have another PSA test scheduled for early October; my doctor wants to wait until my PSA hits 1 before
My PSA started rising after 6 years of being undetectable. July 2023 , PSA 0.10 and July 2024 PSA 0.70 . I had a PSMA pet scan when my PSA hit 0.30 in November 2023 , scan did not show any cancer. I have another PSA test scheduled for early October; my doctor wants to wait until my PSA hits 1 before
Rfs1975
in
Advanced Prostate Cancer
2 hours ago
Zanda after Zytiga
Orgovyx and Zytiga brought my Gleason 9 cancer to a PSA of 0.67, but after 5 months my PSA has slowly risen to 1.59. Would it help to switch from Zytiga to Zanda? Poollover
Orgovyx and Zytiga brought my Gleason 9 cancer to a PSA of 0.67, but after 5 months my PSA has slowly risen to 1.59. Would it help to switch from Zytiga to Zanda? Poollover
Poollover
in
Advanced Prostate Cancer
15 hours ago
Cardiac surgery meds bring PSA down?
My PSA was 1.6 on January 8 of this year. On January 31st I had successful open-heart surgery to repair a heart valve. On March 7th, my next blood test, my PSA had dropped to .5. Has anyone here heard that this sort of drop after surgery is normal? Perhaps there are meds used at that time that could
My PSA was 1.6 on January 8 of this year. On January 31st I had successful open-heart surgery to repair a heart valve. On March 7th, my next blood test, my PSA had dropped to .5. Has anyone here heard that this sort of drop after surgery is normal? Perhaps there are meds used at that time that could
Runner4000
in
Advanced Prostate Cancer
3 days ago
I owe you an update
Many thanks to the members of this forum. FYI, I was diagnosed with a DRE last October, 2023. I had a biopsy in November and confirmed an aggressive stage 5, Gleason 9 in 6 of 12 cores prostate cancer. A series of scans did not detect involvement beyond the prostate. My PSA was 9 at that time. I began
Many thanks to the members of this forum. FYI, I was diagnosed with a DRE last October, 2023. I had a biopsy in November and confirmed an aggressive stage 5, Gleason 9 in 6 of 12 cores prostate cancer. A series of scans did not detect involvement beyond the prostate. My PSA was 9 at that time. I began
Worked_the_World
in
Advanced Prostate Cancer
3 days ago
Bayer announces positive topline results for NUBEQA® (darolutamide) from Phase III trial in men with mHSPC - July 17, 2024
Bayer announces positive topline results for NUBEQA® (darolutamide) from Phase III trial in men with metastatic hormone-sensitive prostate cancer (mHSPC) July 17, 2024 Phase III ARANOTE trial met primary endpoint, significantly increasing radiological progression-free survival (rPFS) with NUBEQA
Bayer announces positive topline results for NUBEQA® (darolutamide) from Phase III trial in men with metastatic hormone-sensitive prostate cancer (mHSPC) July 17, 2024 Phase III ARANOTE trial met primary endpoint, significantly increasing radiological progression-free survival (rPFS) with NUBEQA
cujoe
in
Fight Prostate Cancer
4 days ago
Cancer Turned Aggressive?
My dad has been battling prostate cancer for 15+ years . He goes to University of Chicago. He is 74. Early 2000’s- prostate removed - not clean margins. Did no further treatment 2004 - Cancer came back. Only seen on PSA test. Watched for years until PSA finally doubled. 2007-2008- went on Lupron
My dad has been battling prostate cancer for 15+ years . He goes to University of Chicago. He is 74. Early 2000’s- prostate removed - not clean margins. Did no further treatment 2004 - Cancer came back. Only seen on PSA test. Watched for years until PSA finally doubled. 2007-2008- went on Lupron
Jshaw916
in
Advanced Prostate Cancer
5 days ago
Looking for support in supporting my husband
This community has been so informative and I truly appreciate the information I have received from so many incredible people. Thank you! This is the first time I am posting to this group. In October 2023 my husband noticed more frequent use of the bathroom. He had his PSA tested in January which was
This community has been so informative and I truly appreciate the information I have received from so many incredible people. Thank you! This is the first time I am posting to this group. In October 2023 my husband noticed more frequent use of the bathroom. He had his PSA tested in January which was
Smmac15
in
Advanced Prostate Cancer
5 days ago
Treatment After Progression in Metastatic Castration-Resistant Prostate Cancer: some options
Interesting perspective, but we need more weapons still! https://www.onclive.com/view/piecing-the-puzzle-together-treatment-after-progression-in-metastatic-castration-resistant-prostate-cancer
Interesting perspective, but we need more weapons still! https://www.onclive.com/view/piecing-the-puzzle-together-treatment-after-progression-in-metastatic-castration-resistant-prostate-cancer
Maxone73
in
Advanced Prostate Cancer
5 months ago
Question
Was diagnosed with stage 4 metastatic prostate cancer with several mets to the bones and a Gleason score of 10. This was in January 2023. I have been on darolutamide and relugolix since then and also 6 rounds of docetaxol. Everything was good until recently with an increase in PSA from non detectable
Was diagnosed with stage 4 metastatic prostate cancer with several mets to the bones and a Gleason score of 10. This was in January 2023. I have been on darolutamide and relugolix since then and also 6 rounds of docetaxol. Everything was good until recently with an increase in PSA from non detectable
lovepockets
in
Advanced Prostate Cancer
8 days ago
looking for input - RIsing PSA with Negative PSMA Pet scan
diagnosed in 2020 with Oligometastatic prostate cancer (1 spot detected on right ischium (hip)). Had prostate removed via surgery, did 39 radiation treatments to hip and prostate bed and took Lupron and Erleada . Stopped the hormone therapy in July 2022 (psa undetectable for 2 yrs). My psa in 2024
diagnosed in 2020 with Oligometastatic prostate cancer (1 spot detected on right ischium (hip)). Had prostate removed via surgery, did 39 radiation treatments to hip and prostate bed and took Lupron and Erleada . Stopped the hormone therapy in July 2022 (psa undetectable for 2 yrs). My psa in 2024
ND1988
in
Advanced Prostate Cancer
11 days ago
Minor change in psa - reason to be concern?
Hi, My dad just got an update on his PSA #. 3 weeks ago his PSA was 0.37, our family went on vacation, and he just got back and had his blood work done again. All enzymes normal, but PSA ticked up slightly to 0.47. Is this concerning at all? I thought PSA was suppose to trend to undetectable levels
Hi, My dad just got an update on his PSA #. 3 weeks ago his PSA was 0.37, our family went on vacation, and he just got back and had his blood work done again. All enzymes normal, but PSA ticked up slightly to 0.47. Is this concerning at all? I thought PSA was suppose to trend to undetectable levels
Cafu6
in
Advanced Prostate Cancer
12 days ago
RT with ADT Relogolix (Orgovyx) vs Enzalutamide (Xtandi) Side Effect Differences?
There may not be a lot of people that can offer anecdotal reports on both as monotherapies but the reason I ask is some studies in the last 3 years are showing administration of Xtandi during Radiotherapy has shown outcomes as good as if not better than RT + ADT. https://www.sciencedirect.com/science
There may not be a lot of people that can offer anecdotal reports on both as monotherapies but the reason I ask is some studies in the last 3 years are showing administration of Xtandi during Radiotherapy has shown outcomes as good as if not better than RT + ADT. https://www.sciencedirect.com/science
jazj
in
Advanced Prostate Cancer
5 months ago
Update on Treatment
In June 2023, a routine PSA test value turned out to be 4.6, did an MRI; Diagnosed with Prostate Cancer, Gleason Score 7 (3+4), biopsy said one core. (Details in my profile). Opted for Active Surveillance. But in Oct 2023, PSA level went to 6.1 and in Jan 2024 PSA went to 9.2 In March 2024, did another
In June 2023, a routine PSA test value turned out to be 4.6, did an MRI; Diagnosed with Prostate Cancer, Gleason Score 7 (3+4), biopsy said one core. (Details in my profile). Opted for Active Surveillance. But in Oct 2023, PSA level went to 6.1 and in Jan 2024 PSA went to 9.2 In March 2024, did another
Sushupthi
in
Advanced Prostate Cancer
16 days ago
Bone metastasis drug looks good: phase 2 trial of PT-112 gave good results
"Further, PT-112 harbors a property known as osteotropism, or the propensity of the drug to reach its highest concentrations in certain areas of the bone, making it a candidate for treatment of patients with cancers that originate in, or metastasize to, the bone." https://www.biospace.com/article/releases
"Further, PT-112 harbors a property known as osteotropism, or the propensity of the drug to reach its highest concentrations in certain areas of the bone, making it a candidate for treatment of patients with cancers that originate in, or metastasize to, the bone." https://www.biospace.com/article/releases
Maxone73
in
Advanced Prostate Cancer
5 months ago
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