Zanda after Zytiga

[Poollover]

Orgovyx and Zytiga brought my Gleason 9 cancer to a PSA of 0.67, but after 5 months my PSA has slowly risen to 1.59. Would it help to switch from Zytiga to Zanda? Poollover

[Poollover]

Not Zanda, but Xtandi. Thanks to these drugs I can't spell any longer. Poollover

[God_Loves_Me]

Yes Xtandi or nubeqa also work for you.

Copied from your profile :

Is there anything I can do to bring it down still lower, ideally to an undetected level?

Answer: It is my personal opinion, Please try to find ADC clinical trials. I am pretty sure it will help you out.

[Tall_Allen]

ould you please fill in your profile with more info? I have no idea what your history is - metastases- where, how many? treatments?

[vintage42]

"Orgovyx and Zytiga brought my Gleason 9 cancer to a PSA of 0.67, but after 5 months my PSA has slowly risen to 1.59..."

What was the starting PSA, and how long were you on Orgovyx and Zytiga? It seems like a poor response. That combination reduced my recurrence PSA from 3.78 to .04 after 2 months and .02 after 5 months.

If you have been on Zytiga + Prednisone for a long time, the rising PSA may mean you are becoming castrate-resistant. If so, a switch from Prednisone to Dexamethasone may gain a couple of years on Zytiga, based on SeosamhM's experience: healthunlocked.com/user/Seo...

Or, as you propose, changing from Zytiga (abiraterone) to Xtandi (enzalutamide) could be a good sequence: "Abiraterone followed by enzalutamide treatment is the best sequential treatment for most docetaxel-naïve patients." ncbi.nlm.nih.gov/pmc/articl...

[j-o-h-n]

Remember, you and I are the same age........... ask your doc if Nubeqa would be a med he would prescribe for you (replaced my Casodex and has lowered my PSA). 1936 - Good Year (Depression/War babies).....

Good Luck, Good Health and Good Humor.

j-o-h-n

[RyderLake2]

Hello,

Xtandi (denosumab) or in lesser amounts Prolia does not affect your prostate cancer. It simply strengthens your bones and by doing this, hopefully, it might prevent a skeletal related event (SRE) such as a bone fracture.

[Poollover in reply to RyderLake2]

I don't think you're correct. "Enzalutamide, sold under the brand name Xtandi, is a nonsteroidal antiandrogen medication which is used in the treatment of prostate cancer."

[APK3 in reply to RyderLake2]

Rider I think you thinking of Xgeva.

[RyderLake2 in reply to APK3]

Whoops! I must have had a senior moment

[RyderLake2]

sometimes I think I am losing it.

[APK3 in reply to RyderLake2]

Xgeva..Xtandi...It's just wrong we even have that in our vocabulary... Good Scrabble words tho.