Treatment After Progression in Metastatic Castration-Resistant Prostate Cancer: some options

[Maxone73]

Interesting perspective, but we need more weapons still!

onclive.com/view/piecing-th...

[God_Loves_Me]

looks B7-H3 Targeted Agents and ARX517 work similar way..

[JohnInTheMiddle]

Thanks for posting Max! When I read it and I was a feeling a little foggy this morning so I can't say I captured every nuance - I can't help but feeling a little depressed when the big news is "an extra four months". For all the sophisticated drugs we hear about it's always an extra 4 months. With lazy journalists hyping press releases without context. Triplet therapy in the other hand adds years - until you hit resistance because of selection pressure. But at least it's years! Can you tease out any good news here? Thanks Max.

[Maxone73 in reply to JohnInTheMiddle]

mmmmmm….ok , OsteoDex by dextech, pt-112, and imugene oncolytic virus

[Maxone73 in reply to JohnInTheMiddle]

today it’s not a great day for me as well, but let’s see what I will find tomorrow….there has been a great acceleration, I hope there won’t be too many bottlenecks

[JohnInTheMiddle in reply to Maxone73]

I hear you Max! I've been an advocate for exercise with volume and intensity. And then I learned about over exercising. I'm now working to build I foundation of metabolic fitness based on Z1 and Z2 level exercise. But who are doing it in order to earn those myokines against prostate cancer seems harder to do than I imagined. Apparently recovery is a thing. I'm not exactly a scientist or exercises concerned. Everything is too difficult! You are a newlywed and we still have a teenager at home! Someday you will have teenagers at home! Heaven help us all. But as you say there has been a great acceleration in terms of prostate cancer understanding or more generally hormone-based cancer understanding. I really liked your coining of the phrase acceleration, in this context. I'm totally in with you on that!

[dhccpa in reply to JohnInTheMiddle]

We'd better get done whatever the hell needs doing in that four months, whenever it arrives!

[JohnInTheMiddle in reply to dhccpa]

Getting one's affairs in order hopefully already done! Because likely due to fatigue, brain fog, sleep disruption, emotional panic, therapy logistics, therapy side-effects and more, one won't be "on the top of one's game", to say the least ...

[dhccpa in reply to JohnInTheMiddle]

Very true. Like you, I get frustrated that each new thing adds that same few months. After Lupron, things do seem to offer less time.

[JohnInTheMiddle in reply to dhccpa]

Bravo Max! It's a new concept in time - "after Lupron". Or in my case "after Degarelix". Before "after Lupron", mPCa time has this longish period where its chronic. The whole goal of PCa research is turn PCa into a chronic disease. I was thinking of writing a blog post on the topic of chronic metastatic prostate cancer and focusing on staying in the ADT steady-state as long as possible.

[dhccpa in reply to JohnInTheMiddle]

You write it, and I'll read it! I always find your posts interesting.

[Maxone73 in reply to JohnInTheMiddle]

This does not sound bad at all!!

[32Percenter in reply to JohnInTheMiddle]

I haven't read the article but something to keep in mind is that these time projections on studies are a mean calculation, meaning for the entire group. Two non-responders may die a week into the study, another few 3 months in, while the rest live 2 years+. Those deceased folks may have died from causes other than aPCa anyway, but their deaths average it out to "4 more months" for the group.

[Maxone73 in reply to 32Percenter]

Technically they use median to avoid that situation because average is too influenced by outliers….but yes, all mortality causes are taken into account, plus they usually are older patients heavily pretreated and so on…

I am more inclined to notice the trends in new techniques and the amount of research and clinical trials that are being done rather than the results in term on months…and both are impressive. 😀

The definitive solution to the problem can only come from gene editing imho, and in fact they are working hard on crispr techniques. If what has been done for beta thalassemia and sickle cell disease will be confirmed in the next month, we will see an even bigger effort.

[dhccpa in reply to 32Percenter]

Very true

[Ian99]

Hi Max. Hope for a breakthrough keeps us going. Plus visits to the gym. Your efforts are appreciated. Molto grazie!

[Maxone73 in reply to Ian99]

I try!