Cardiac surgery meds bring PSA down?

[Runner4000]

My PSA was 1.6 on January 8 of this year. On January 31st I had successful open-heart surgery to repair a heart valve. On March 7th, my next blood test, my PSA had dropped to .5. Has anyone here heard that this sort of drop after surgery is normal? Perhaps there are meds used at that time that could be of assistance to some of us. An acquaintance told me of a heart-attack friend of his who had a similar experience--PSA drop after heart meds.

[Justfor_]

I witnessed PSA decline after long COVID left me with Tachycardia and cardiologist prescribed Beta blockers to address it. My explanation, based on fluid mechanics, is that as the flow of circulating blood and its head pressure get lowered, the hormone carrying capacity -especialy to capillary vessels feeding cancerous cells- is also lowered. A type of "mechanical" ADT. If the drugs you were prescribed affected blood head and flow rate (i.e. cardiac pulse rate) you may be an additional proof to my theory.

[Runner4000 in reply to Justfor_]

I was on a heart-lung machine for 35 minutes while they were operating on my heart. That may have impacted the blood flow.

[PSAed]

I’ve had a Triple bypass 7 months ago, still on blood thinners, Statins, and metoprolol. My damn PSA is steadily increasing, last 3 consecutive results !!

[Runner4000 in reply to PSAed]

Sorry…

[dentaltwin]

I had a mitral valve repair (annuloplasty) on March 20. I can't speak to PSA (so far I'm undetectable) but although my blood loss was "trivial", I definitely tested anemic about a month later.

My postop meds were low-dose aspirin, metaprolol, and colchicine (plus pain meds).

[PSAed in reply to dentaltwin]

Thanks for mentioning the anemia. I’m also anemic but thought it was was from the ADT/RT , now …considering your post ….my anemia may very well be from the heart bypass operation.

I mean my anemia may have cleared up after the ADT/HT, but returned after the heart operation.

[dentaltwin in reply to PSAed]

I have tested anemic from time to time, even before my PC diagnosis, but never severe. Incidentally, my kid brother (who's also had PC) was testing more severely anemic; turned out the celiac disease he was diagnosed with as an infant (and we were told he'd outgrow)--well, he didn't outgrow it.

Also, after my heart surgery some of my thyroid function tests were off (but have since returned to normal). Also, the pre-op CT (chest, abdomen, pelvis) disclosed a nodule on my thyroid. Never a dull moment.

[Runner4000 in reply to PSAed]

I’ve been prescribed daily 65 mg iron tablet. Also need a 1/day stool softener as the iron stops you up. Will re- check in several months. I think it’s because of blood loss during the operation. I suppose it could also have to due with ADT, as I’m on 3 month Lupron. Will see what develops…

[Runner4000]

Thanks. Yes, I tested as anemicalso.

[j-o-h-n]

That's normal since your PSA is now controlled by a replacement slow mickey mouse pocket Runner's watch.

Good Luck, Good Health and Good Humor.

j-o-h-n

[Runner4000 in reply to j-o-h-n]

Oh, that’s helpful to know. Explains my Minnie Mouse dreams….

[j-o-h-n]

Haha................ She's mine..... She's mine.............

Good Luck, Good Health and Good Humor.

j-o-h-n