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PSMA-Addition Trial can give access to Pluvicto for DeNovo or mHSPC
The range of access to Pluvicto (Lu177-PSMA-617) radionuclide treatment is expanding. Great news. The PSMA-Fore trial recently showed that it iis very beneficial before docetaxel chemotherapy in mCRPC. Now a worldwide trial is exploring it in metastatic hormone sensitive PC, including de novo metastatic
The range of access to Pluvicto (Lu177-PSMA-617) radionuclide treatment is expanding. Great news. The PSMA-Fore trial recently showed that it iis very beneficial before docetaxel chemotherapy in mCRPC. Now a worldwide trial is exploring it in metastatic hormone sensitive PC, including de novo metastatic
MateoBeach
in
Advanced Prostate Cancer
3 months ago
Neuroendocrine prostate cancer could be restored to a state that responds to treatment
[i]It may be possible to restore drug-resistant neuroendocrine prostate cancer to a state that responds to treatment by depletion of a certain protein in cancer cells. A recent study published in Communications Biology by the University of Eastern Finland found that this protein, DPYSL5, is expressed
[i]It may be possible to restore drug-resistant neuroendocrine prostate cancer to a state that responds to treatment by depletion of a certain protein in cancer cells. A recent study published in Communications Biology by the University of Eastern Finland found that this protein, DPYSL5, is expressed
Don_1213
in
Advanced Prostate Cancer
3 months ago
How soon after stopping Zoladex, prostap etc did you get your period ? And how soon after stopping did you stop using HRT?
Hi, How soon after coming off injection can I expect to get a period? Also wondering at what point did you stop HRT ?
Hi, How soon after coming off injection can I expect to get a period? Also wondering at what point did you stop HRT ?
Amber83
in
Endometriosis UK
1 year ago
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Triplet Therapy for HSPC
This article came over on the Prostate Cancer Newletter. https://www.onclive.com/view/dr-sharma-on-questions-regarding-the-optimal-use-of-triplet-therapies-in-hspc?utm_medium=email&utm_source=rasa_io&utm_campaign=newsletter I am unsure based on lack of detail and to a smaller extent a comment by
This article came over on the Prostate Cancer Newletter. https://www.onclive.com/view/dr-sharma-on-questions-regarding-the-optimal-use-of-triplet-therapies-in-hspc?utm_medium=email&utm_source=rasa_io&utm_campaign=newsletter I am unsure based on lack of detail and to a smaller extent a comment by
treedown
in
Advanced Prostate Cancer
4 months ago
Scared and Feeling Helpless
Let me start by saying that it was my intention to wait for an official diagnosis for my dad before I started posting here. I found this group recommended on the Prostate Cancer Reddit Forum. I’ve been really struggling lately with absolute utter fear and lack of control (more on that later). My dad
Let me start by saying that it was my intention to wait for an official diagnosis for my dad before I started posting here. I found this group recommended on the Prostate Cancer Reddit Forum. I’ve been really struggling lately with absolute utter fear and lack of control (more on that later). My dad
Cafu6
in
Advanced Prostate Cancer
4 months ago
ADT Holiday?
I'm posting for my husband. Gleason 9, cdk12, reoccurrence 18 months after RP. Scans cancer in lymph node and possibly sternum. Had radiation and 2 successful years of Orgovyx and Zytiga. Dr says he can take a holiday from meds but my husband is concerned that the cancer will return without meds
I'm posting for my husband. Gleason 9, cdk12, reoccurrence 18 months after RP. Scans cancer in lymph node and possibly sternum. Had radiation and 2 successful years of Orgovyx and Zytiga. Dr says he can take a holiday from meds but my husband is concerned that the cancer will return without meds
RunnerBiker
in
Advanced Prostate Cancer
4 months ago
OsteoDex: for mCRPC bone metastasis!
clinical trials are going well, and results are better than with zometa or Denosumab! https://mb.cision.com/Main/11652/3853506/2358495.pdf
clinical trials are going well, and results are better than with zometa or Denosumab! https://mb.cision.com/Main/11652/3853506/2358495.pdf
Maxone73
in
Advanced Prostate Cancer
4 months ago
Froedtert & the Medical College of Wisconsin Cancer Network created the Bone Metastasis Program
there will also be clinical trials focused on bone metastasis https://www.froedtert.com/stories/treating-cancer-spreads-bones
there will also be clinical trials focused on bone metastasis https://www.froedtert.com/stories/treating-cancer-spreads-bones
Maxone73
in
Advanced Prostate Cancer
4 months ago
Phase 2 trial recruiting: revert hormone resistance with apalutamide and ENV105
In phase 1 it worked with 44% of patients it seems, it's multisite, it could be worth trying for our warrior with mCRPC (metastatic castrate resistant prostate cancer) https://www.biospace.com/article/releases/kairos-pharma-doses-first-patient-in-phase-2-trial-of-lead-drug-candidate-env105-with-apalutamide-to-improve-therapy-sensitivity-for-castrate-resistant-prostate-cancer
In phase 1 it worked with 44% of patients it seems, it's multisite, it could be worth trying for our warrior with mCRPC (metastatic castrate resistant prostate cancer) https://www.biospace.com/article/releases/kairos-pharma-doses-first-patient-in-phase-2-trial-of-lead-drug-candidate-env105-with-apalutamide-to-improve-therapy-sensitivity-for-castrate-resistant-prostate-cancer
Maxone73
in
Advanced Prostate Cancer
4 months ago
LATITUDE secondary analysis - Concurrent use of Abiraterone and NSAIDs - higher risk of Prostate Cancer Specific Mortality and inferior OS
https://doi.org/10.1200/JCO.2024.42.4_suppl.120 ”Conclusions: In this secondary analysis, concomitant exposure to 7 classes of medications was not associated with any statistically significant modification of abiraterone effect on OS in de novo high risk mHSPC. Men who received concurrent NSAIDs had
https://doi.org/10.1200/JCO.2024.42.4_suppl.120 ”Conclusions: In this secondary analysis, concomitant exposure to 7 classes of medications was not associated with any statistically significant modification of abiraterone effect on OS in de novo high risk mHSPC. Men who received concurrent NSAIDs had
Graham49
in
Advanced Prostate Cancer
4 months ago
Agonists vs. antagonists (the latter not to be confused with a character in a novel!)
I know many of you on this site are beyond ADT, but for those who are still holding on in that space, I'd like to share my experience with the newer antagonists drugs, degarelix ( U.S. brand, Firmagon) and relugolix (U.S. brand, Orgovyx). I started ADT exactly 8 years ago this month and during my off-and-on
I know many of you on this site are beyond ADT, but for those who are still holding on in that space, I'd like to share my experience with the newer antagonists drugs, degarelix ( U.S. brand, Firmagon) and relugolix (U.S. brand, Orgovyx). I started ADT exactly 8 years ago this month and during my off-and-on
bluesnjazz
in
Advanced Prostate Cancer
4 months ago
A little Great News!
Hello Friends, A couple years ago our journey began. I was scared, panicked, and at a complete loss as my husband was diagnosed with stage 4 prostate cancer at age 49. He had 17 bone Mets. After some amazing input from this community and special advice from Tall Allen, I was able to set my sights
Hello Friends, A couple years ago our journey began. I was scared, panicked, and at a complete loss as my husband was diagnosed with stage 4 prostate cancer at age 49. He had 17 bone Mets. After some amazing input from this community and special advice from Tall Allen, I was able to set my sights
Lshanks07
in
Advanced Prostate Cancer
4 months ago
The MAO inhibitors phenelzine and clorgyline revert enzalutamide resistance in castration resistant prostate cancer
I am not using enza (yet) wondering if it's worth taking some nutmeg to keep those mao in check anyway! :-P https://www.nature.com/articles/s41467-020-15396-5
I am not using enza (yet) wondering if it's worth taking some nutmeg to keep those mao in check anyway! :-P https://www.nature.com/articles/s41467-020-15396-5
Maxone73
in
Fight Prostate Cancer
4 months ago
Skull Metastasis
I just received an order for a brain M RI from Dr. Aggarwal. I was wondering why. My recent PSMA PET scan an d probably confirmed by SPECT scans after Pluvicto show bone metastasis in my skull as well as in other bones (one of which has an SUV of 38) and which was quite painful before Pluvicto but has
I just received an order for a brain M RI from Dr. Aggarwal. I was wondering why. My recent PSMA PET scan an d probably confirmed by SPECT scans after Pluvicto show bone metastasis in my skull as well as in other bones (one of which has an SUV of 38) and which was quite painful before Pluvicto but has
spencoid2
in
Advanced Prostate Cancer
4 months ago
Do you that have had Orchiectomy still take ATD Medication?
I’ve been told that I will be on ATD meds for life, I’m 63 and have been taking Lupron and Zytiga for going on two years. I asked my MO about Orchiectomy and he said if I did it he would still recommend Lupron. Can you guys please share your thoughts and experiences? Thank you in advance
I’ve been told that I will be on ATD meds for life, I’m 63 and have been taking Lupron and Zytiga for going on two years. I asked my MO about Orchiectomy and he said if I did it he would still recommend Lupron. Can you guys please share your thoughts and experiences? Thank you in advance
OldGuysRule
in
Advanced Prostate Cancer
4 months ago
"Castration resistant"
What is the relevance of this term and how does one know if it applies to them? I am stage 4, three mets in the back for which I have already received radiation treatment along with same on prostate. I have had 2 Eligard shots and been on 500 mgs of Abiraterone plus 5mgs of prednisone daily. Can I
What is the relevance of this term and how does one know if it applies to them? I am stage 4, three mets in the back for which I have already received radiation treatment along with same on prostate. I have had 2 Eligard shots and been on 500 mgs of Abiraterone plus 5mgs of prednisone daily. Can I
GrantB47
in
Advanced Prostate Cancer
4 months ago
Lutetium - PSMA Earlier
For those members of this forum interested in the use of lutetium and where it 'fits' in the treatment of prostate cancer, this webinar from the [i]Prostate Theranostics Imaging Centre of Excellence[/i] and the [i]International Cancer Imagining Society[/i] is sure to be of interest. The discussion
For those members of this forum interested in the use of lutetium and where it 'fits' in the treatment of prostate cancer, this webinar from the [i]Prostate Theranostics Imaging Centre of Excellence[/i] and the [i]International Cancer Imagining Society[/i] is sure to be of interest. The discussion
marnieg46
in
Fight Prostate Cancer
4 months ago
PET Scan Results
Can anyone help me interpret my PET scan results from yesterday, and suggest possible courses of action? They seemed bad, but not disastrous. “Focal uptake in the right prostate bed (max SUV 5.3) as well as the right lesser trochanter (max SUV 4.5), not present on the prior study, suspicious for
Can anyone help me interpret my PET scan results from yesterday, and suggest possible courses of action? They seemed bad, but not disastrous. “Focal uptake in the right prostate bed (max SUV 5.3) as well as the right lesser trochanter (max SUV 4.5), not present on the prior study, suspicious for
Murph256
in
Advanced Prostate Cancer
4 months ago
In vitro but...fighting bone metastasis
Currently they have tested it on metastasis of breast cancer, but hopefully it could work for all bone metastasis https://www.eurekalert.org/news-releases/1032208
Currently they have tested it on metastasis of breast cancer, but hopefully it could work for all bone metastasis https://www.eurekalert.org/news-releases/1032208
Maxone73
in
Fight Prostate Cancer
4 months ago
Multi-Drug Combo May Be Best Against Prostate Cancer...I thought it was a known fact already!
"Combining two or three testosterone-blocking drugs prevents the spread of prostate cancer better than just a single medication, a new clinical trial has found." Dr Aggrawal again! https://www.usnews.com/news/health-news/articles/2024-01-25/multi-drug-combo-may-be-best-against-prostate-cancer
"Combining two or three testosterone-blocking drugs prevents the spread of prostate cancer better than just a single medication, a new clinical trial has found." Dr Aggrawal again! https://www.usnews.com/news/health-news/articles/2024-01-25/multi-drug-combo-may-be-best-against-prostate-cancer
Maxone73
in
Advanced Prostate Cancer
4 months ago
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