Second Line Hormonal

[Islandboy2021]

I am still only receiving Zoladex injections every three months. I did try Abiraterone 2022/2023 and it failed after a few months. I have been trying to get my Oncologist to prescribe Enzalutamide. I have been treated with docetaxel again and thought it might re-sensitize me for another hormonal drug.

Does anyone have any thoughts or experience with a situation like this. My thoughts are that I should be trying everything available that could slow my progression. SOC at the moment does not really have any options for me other than the chemo.

[WisdomSeeking]

Please read this post on Tall Allen's blog:

Docetaxel Extends Enzalutamide Effectiveness (October 28, 2022)

prostatecancer.news/2022/10...

[sammycanine]

Hi

What do you mean when you say it failed?

[Islandboy2021 in reply to sammycanine]

PSA continued to climb and started to get bone pain for the first time.

[sammycanine]

Has your Oncologist told you that you are castration resistant? If so, hormone therapies no longer work, though they are sometimes still included in Chemo therapies.

[Islandboy2021 in reply to sammycanine]

Yes, I am castrate resistant now. I still continue with the ADT.

[Jaguarxj]

I think it was a mistake to take that holiday. I've been tempted myself but my oncologist has advised me against it. I'm taking Zolidex & Xtandi now going on 3 years. I have lost a lot of strength, not able to walk more then 10 minutes at a time, but I'm able to ride a bicycle every day unlimited time. But when I get my PSA still going strong at .02. Tell your OC you have to get on xtandi with your Zoladex

[Islandboy2021]

I know it was a mistake. I had no idea what this disease was and how serious it was. You really need to educate yourself about your disease. I was young at 52 when diagnosed and kept busy working and spending time with family. I didn't spend much time researching my disease. I had a low PSA for 3 or 4 years and the treatments that I first had worked very well. Now it is uncontrollable and I am struggling to get some control.

[Mgtd in reply to Islandboy2021]

any update on what you did?

[Islandboy2021 in reply to Mgtd]

I have been doing chemo since November. I have had 7 cycles of Docetaxel and another 7 cycles of Cabazitaxel. I am waiting to get on a trial for Lu-177. PSA has been up and down with the chemo. Scans show no new signs of progression though.