Statin use and outcomes of oncological treatment for castration-resistant prostate cancer - From the Finnish poulation, Nature, 11/01/23

[CaptnMojoe]

As a follow-up to recent posts on statins and PCa, here is another Euopean study, this time from the Finns. As noted in the Abstract below, they come to the conclusion of no/little benefit for crPCa, but maybe some for csPCa.

The apparent pooling of data for specific type/form of statin does not provide any guidance on any benefit of one vs another.

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Abstract

To compare the effect of statin use in relation to castration-resistant prostate cancer (CRPC) treatment, we assessed the risk of ADT-treated PCa-patients to initiate CRPC treatment by statin use and the outcomes of CRPC treatment by statin use. Our study cohort consisted of 1169 men who participated in the Finnish Randomized Study of Screening for Prostate Cancer (FinRSPC) and initiated androgen deprivation therapy (ADT) during the follow-up (1996-2017). Statin use was associated with slightly decreased risk of initiating CRPC treatment (HR 0.68; 95% CI 0.47-0.97) with a 5.7 years' median follow-up until CRPC for non-users and 7.5 years for statin users. The risk of discontinuation of first or second line CRPC treatment due to inefficacy was not modified by statin use and the results remained similar in subgroup analysis assessing separately patients treated with taxans or androgen receptor signaling inhibitors. We observed an inverse association between statin use and the risk of initiation of the CRPC treatment. No beneficial risk modification by statin use during CRPC treatment was observed. These results suggest that statins might be beneficial during hormone-sensitive phase but not in the later phases of prostate cancer treatment.

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Full paper here:

Statin use and outcomes of oncological treatment for castration-resistant prostate cancer, Nature, Scientific Reports, 2023, Nov 01.

nature.com/articles/s41598-...

Saluti - Mojoe

[PCaWarrior]

Meta analysis of 3 trials.

Not a cure. Inexpensive, conventional, reduces CVD risk, simple, very low sides (most of them are present only in people who expect side effects from statins).

statin

[PhilipSZacarias]

Thank you for posting