PSA 6 months after RT

[janebob99]

Here is a review of a presentationby Dr. Ravi at ASCO 2023, regarding measuring the PSA at 6 months post radiation treatment, for all risk groups. He found that the 6-month post-RT PSA was highly prognostic of 5- and 10-year rates of metastasis free survival (MFS), Overall Survival (OS), and prostate cancer mortality (PCSM). They looked at over 10,000 patients over a period of 10 years, and found that if your 6-month PSA is 0.1, then you might need to intensify the ADT treatment (longer course and/or adding extra drugs).

urotoday.com/conference-hig...

[Tall_Allen]

IMO, very wrong to lump risk groups. Very few favorable risk patients today would get ADT and their PSA at 6 months post RT would be way higher than 0.1, yet would have excellent prognosis. Also, for men taking ADT, PSA≤0.1 is common. It is only prognostic if a high risk patient has not responded to ADT.

[janebob99 in reply to Tall_Allen]

That's a valid criticism. Usually they report outcomes for a selected risk group.

This was an extended Abstract presentation at ASCO 2013. He probably only had 10 minutes to talk. It was a large study, over 10,000 patients covering 10 years of data from the ICECAP database. I'm sure that when they eventually publish a complete paper, they will report the results for individual risk groups.

I think the key finding is that, in general, the PSA level (at 6-months post RT) is highly predictive of future outcomes, with PSA = 0.1 being a critical level.

[Tall_Allen in reply to janebob99]

That is incorrect, for the reason I just gave.

[janebob99]

Just reporting what was presented. I don't have an opinion about their conclusions.

[j-o-h-n]

Don't shoot the messenger..........(been there, done that and can show you the bullet holes in my done that tee shirt....)....

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 01/12/2024 7:31 PM EST

[janebob99 in reply to j-o-h-n]

Thanks. I appreciate the wise words.

[janebob99]

Thanks. I'm learning.