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Rasagiline: The Neuroprotective Activities of the Novel Multi-Target Iron-Chelators in Models of Alzheimer’s Disease, ALS and Aging
https://www.mdpi.com/2073-4409/12/5/763/html However, accumulating evidence has shown that iron-dependent oxidative stress (OS), increased iron levels, and monoamine oxidase (MAO)-B activity, as well as reduced antioxidant levels and activities in the brain, maybe major pathogenic factors in neurodegenerative
https://www.mdpi.com/2073-4409/12/5/763/html However, accumulating evidence has shown that iron-dependent oxidative stress (OS), increased iron levels, and monoamine oxidase (MAO)-B activity, as well as reduced antioxidant levels and activities in the brain, maybe major pathogenic factors in neurodegenerative
Hidden
in
Cure Parkinson's
1 year ago
Severe flare up
Hi all I was diagnosed with IBS last year after blood tests and a stool sample. Since then I’ve not really had any further advice and have continued to live with frequent loose bowel movements. However over the last week I have had extremely watery loose stools that have been so frequent I have been
Hi all I was diagnosed with IBS last year after blood tests and a stool sample. Since then I’ve not really had any further advice and have continued to live with frequent loose bowel movements. However over the last week I have had extremely watery loose stools that have been so frequent I have been
Ezz25
in
IBS Network
1 year ago
Pregnancy, IBS D and a gallstone
Hi, I was recently told I had a gallstone and would need an operation to remove my gallbladder in the future.Dr said to avoid fatty/ spicy foods too.Then I discovered I am pregnant. Upon discovering this I stopped taking my loperamide.I usually take 2 every morning.The next day the diarrhoea started
Hi, I was recently told I had a gallstone and would need an operation to remove my gallbladder in the future.Dr said to avoid fatty/ spicy foods too.Then I discovered I am pregnant. Upon discovering this I stopped taking my loperamide.I usually take 2 every morning.The next day the diarrhoea started
Blue_Dahlia
in
IBS Network
1 year ago
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Husband had a severe TBI
HiI often read these stories as they give me comfort. They also offer a different perspective as I didn t suffer a TBI injury, my husband did after a kite boarding accident. 28 days in a coma several months in rehab. No one thought he would survive yet alone return home and to work. But I have a different
HiI often read these stories as they give me comfort. They also offer a different perspective as I didn t suffer a TBI injury, my husband did after a kite boarding accident. 28 days in a coma several months in rehab. No one thought he would survive yet alone return home and to work. But I have a different
Daylesford
in
Headway
1 year ago
Hypoxic injury
Good evening my partner is currently in ICU with an hypoxic brain injury. Its been 4 weeks now and I is so scary. Any good stories on here about this?
Good evening my partner is currently in ICU with an hypoxic brain injury. Its been 4 weeks now and I is so scary. Any good stories on here about this?
Sineadddddd
in
Headway
1 year ago
slow transit constipation
hi everyone hope you’re all enjoying the Easter break- I’m just looking for some advice - I have had slow transit constipation and IBS/C for many years and recently prescribed Linaclotide which I’ve been taking for a few weeks all this seems to have done is caused severe bloating but not helped with
hi everyone hope you’re all enjoying the Easter break- I’m just looking for some advice - I have had slow transit constipation and IBS/C for many years and recently prescribed Linaclotide which I’ve been taking for a few weeks all this seems to have done is caused severe bloating but not helped with
Rumours
in
IBS Network
1 year ago
Uncontrollable use of toothbrush
My wife has PSP and in the last week when brushing her teeth she starts normally but then starts scrubbing them extremely hard and fast I have had to take the brush out of her hand forcibly. Today her gums were bleeding. This is with a manual toothbrush I am going to try her with an electric brush that
My wife has PSP and in the last week when brushing her teeth she starts normally but then starts scrubbing them extremely hard and fast I have had to take the brush out of her hand forcibly. Today her gums were bleeding. This is with a manual toothbrush I am going to try her with an electric brush that
Wombatz
in
PSP Association
1 year ago
Feeling down
Hi to you all,I'm a bit down today and hope it's okay to offload on you guys. Been having back and stomach pain on 'watch and wait' and my onc said this morning that a gammography showed several metastases on the spine. I already had two bone mets but seems to be spreading fast. So I am now platinum
Hi to you all,I'm a bit down today and hope it's okay to offload on you guys. Been having back and stomach pain on 'watch and wait' and my onc said this morning that a gammography showed several metastases on the spine. I already had two bone mets but seems to be spreading fast. So I am now platinum
Riverflo
in
My Ovacome
1 year ago
Diabetes medication
Can Tradjenta, Linagliptin, a diabetes drug, stop c/l working as effectively eg c/l not lasting as long.
Can Tradjenta, Linagliptin, a diabetes drug, stop c/l working as effectively eg c/l not lasting as long.
JeanieBeanie
in
Cure Parkinson's
1 year ago
partner trouble waking up
my partner 5 weeks ago had a massive bleed on the brain stroke in which she had to have part of her skull removed to relieve pressure . She has been off of sedation for roughly 2 weeks they have put her on a tracheotomy tube she has had a lot of movement in her right leg and limited movement in her right
my partner 5 weeks ago had a massive bleed on the brain stroke in which she had to have part of her skull removed to relieve pressure . She has been off of sedation for roughly 2 weeks they have put her on a tracheotomy tube she has had a lot of movement in her right leg and limited movement in her right
Arsenalfan1986
in
ICUsteps
1 year ago
1dp5dt
My story so far-So after my egg retrieval I had to get both tubes removed because of hydrosalpinx. Had to wait for two bleeds before starting FET. Transfer day was yesterday the 29th of March. I had two 5d embryos transferred. Because I'm over 40 the doctor suggested two. I have had backpain since
My story so far-So after my egg retrieval I had to get both tubes removed because of hydrosalpinx. Had to wait for two bleeds before starting FET. Transfer day was yesterday the 29th of March. I had two 5d embryos transferred. Because I'm over 40 the doctor suggested two. I have had backpain since
Nachiks
in
Fertility Network UK
1 year ago
Pain management
One of the GPs has declined to give me anything stronger than dihydrocodeine which is no longer helping me cope with my pain. I was in excruciating pain the other night the worst it has ever been and dihydrocodeine never helped. I have another appointment with another gp on Monday and I'm scared they
One of the GPs has declined to give me anything stronger than dihydrocodeine which is no longer helping me cope with my pain. I was in excruciating pain the other night the worst it has ever been and dihydrocodeine never helped. I have another appointment with another gp on Monday and I'm scared they
Elephy
in
Endometriosis UK
1 year ago
Don't get greedy, i.e. be patient, respect the rest days, go slowly etc etc
As a companion piece to Instructor57 's excellent post on Setting the Pace (*nods respectfully in the direction of Tim (RIP) IannodaTruffe) ... have a watch and VERY careful listen of this. It's a vlog from Stephen Scullion, Irish Olympic 2h:09 marathoner who is currently trying to qualify for the
As a companion piece to Instructor57 's excellent post on Setting the Pace (*nods respectfully in the direction of Tim (RIP) IannodaTruffe) ... have a watch and VERY careful listen of this. It's a vlog from Stephen Scullion, Irish Olympic 2h:09 marathoner who is currently trying to qualify for the
John_W
Ambassador
in
Couch to 5K
1 year ago
Osteitis pubis
Hi just wondered if anybody with SLE and hypermobility syndrome has ever been diagnosed with this just had the results of an MRI scan of the pelvis and they've picked up this. Thanks very best wishes
Hi just wondered if anybody with SLE and hypermobility syndrome has ever been diagnosed with this just had the results of an MRI scan of the pelvis and they've picked up this. Thanks very best wishes
sunshine16
in
LUPUS UK
1 year ago
slow recovery from broken ankle
I broke my ankle 18 months ago in three places and had surgery on it, I’ve had physio on it but it still hurts and I walk with a limp Just wondering if anyone else has taken so long to recover from something like this
I broke my ankle 18 months ago in three places and had surgery on it, I’ve had physio on it but it still hurts and I walk with a limp Just wondering if anyone else has taken so long to recover from something like this
Moonshine15
in
Pain Concern
1 year ago
happy death
john 74 lives alone with dog - no relatives in touch as i know what a set of thieving lieing set they are happy with that as dogs are far more superior in there way of life than people-if dogs were running this country or any it would be a much better place to live in , the only other thing i have to
john 74 lives alone with dog - no relatives in touch as i know what a set of thieving lieing set they are happy with that as dogs are far more superior in there way of life than people-if dogs were running this country or any it would be a much better place to live in , the only other thing i have to
rat69
in
Lung Conditions Community Forum
1 year ago
Treating leukocytosis in PV
I was diagnosed with PV in 2015 and I am JAK2 positive. I've been on Jakafi for about six months, and my current dosage of 10 mg/day seems to be doing a good job of controlling my HCT, HGB, and PLT numbers. However, my WBC numbers are consistently high, running at 19-20 K/uL. I understand that the literature
I was diagnosed with PV in 2015 and I am JAK2 positive. I've been on Jakafi for about six months, and my current dosage of 10 mg/day seems to be doing a good job of controlling my HCT, HGB, and PLT numbers. However, my WBC numbers are consistently high, running at 19-20 K/uL. I understand that the literature
sbs_patient
in
MPN Voice
2 years ago
suffering IBS-C feel like I’m trapped in a box….
Im 43 yrs old female I have suffered with constipation my entire life and as a result I have felt awful the majority of my life. I have had every test ran nothing discovered deadly….happy for that part but I’m on Linzess 290mg and I’m not seeing a life changing result. I have been on it for 12 months
Im 43 yrs old female I have suffered with constipation my entire life and as a result I have felt awful the majority of my life. I have had every test ran nothing discovered deadly….happy for that part but I’m on Linzess 290mg and I’m not seeing a life changing result. I have been on it for 12 months
Bellypainhelp
in
IBS Network
2 years ago
speech and language therapy
hi guys. I was wondering if any one on here has had any experience with any private speech and Language therapists. We are looking into using a private speech therapy for our dad who has fluent aphasia. does anyone know a good company? thank you
hi guys. I was wondering if any one on here has had any experience with any private speech and Language therapists. We are looking into using a private speech therapy for our dad who has fluent aphasia. does anyone know a good company? thank you
Maychristine
in
Headway
1 year ago
Patient diaries
Can anyone explain why two separate ICU nurses would each write an entry in my husband's ICU Patient Diary - one to say he was dying and one to tell him he was dead? Why would anyone do something so unkind addressing him by name when he had been unconscious for a week and was on a ventilator? Plus
Can anyone explain why two separate ICU nurses would each write an entry in my husband's ICU Patient Diary - one to say he was dying and one to tell him he was dead? Why would anyone do something so unkind addressing him by name when he had been unconscious for a week and was on a ventilator? Plus
YDHicu
in
ICUsteps
1 year ago
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