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Vitamin B1 and B3 question
Hi, I am seeing all the posts about Vitamin B1 and Niacin. I currently take a dopamine agonist mirapexin and a MAOI Selegeline low dose plus vitamin E, CoenzymQ as prescribed by my neurologist. I also recently started taking vitamin D. Could someone advise how much B1 and B3 to try and what time of day
Hi, I am seeing all the posts about Vitamin B1 and Niacin. I currently take a dopamine agonist mirapexin and a MAOI Selegeline low dose plus vitamin E, CoenzymQ as prescribed by my neurologist. I also recently started taking vitamin D. Could someone advise how much B1 and B3 to try and what time of day
louise2Rookery
in
Cure Parkinson's
3 years ago
The results of the Phase 2 trial: Mevidalen improves motor symptoms
The results of the Phase 2 safety/efficacy, randomized, placebo-controlled trial of Mevidalen (selective PAM of dopamine D1 receptor) in Lewy Body Dementia; N = 344 randomly assigned (1:1:1:1) to daily doses of 10, 30, or 75 mg; Improves motor symptoms. "LY3154207 is a small-molecule, positive allosteric
The results of the Phase 2 safety/efficacy, randomized, placebo-controlled trial of Mevidalen (selective PAM of dopamine D1 receptor) in Lewy Body Dementia; N = 344 randomly assigned (1:1:1:1) to daily doses of 10, 30, or 75 mg; Improves motor symptoms. "LY3154207 is a small-molecule, positive allosteric
Hidden
in
Cure Parkinson's
3 years ago
Desire to view disturbing images
Hi community, I have a strange habit I've never divulged to anyone. Trigger Warning: mention of suicide and graphic material For reasons I do not understand, when I am feeling understimulated, I search for graphic and disturbing images and videos. These include car accidents, suicide, shootings
Hi community, I have a strange habit I've never divulged to anyone. Trigger Warning: mention of suicide and graphic material For reasons I do not understand, when I am feeling understimulated, I search for graphic and disturbing images and videos. These include car accidents, suicide, shootings
Daffodileyes
in
CHADD's Adult ADHD Support
3 years ago
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Does Levodopa cause your brain to produce less of "its own" dopamine?
Does anyone know if there is research on this topic? Does taking C/L actually discourage the brain from producing its own dopamine because it's being fed dopamine from an external source? I just wondered if this question had ever been explored because the human body is lazy. For example, if you
Does anyone know if there is research on this topic? Does taking C/L actually discourage the brain from producing its own dopamine because it's being fed dopamine from an external source? I just wondered if this question had ever been explored because the human body is lazy. For example, if you
Discogs_discogs
in
Cure Parkinson's
3 years ago
Ecopipam and Dr. Ondo.
Can anyone spot the flaw in his reasoning? See last 6 paragraphs after his name in center. As far as I can tell Ecopipam’s closest cousin is cannabis, but that’s neither here nor there New Study Will Test Treatment for Augmentation The RLS Foundation Research Grant Program has awarded $37,000 to William
Can anyone spot the flaw in his reasoning? See last 6 paragraphs after his name in center. As far as I can tell Ecopipam’s closest cousin is cannabis, but that’s neither here nor there New Study Will Test Treatment for Augmentation The RLS Foundation Research Grant Program has awarded $37,000 to William
Hidden
in
Restless Legs Syndrome
3 years ago
Neuroscientist Andrew Huberman 'not a fan' of melatonin since it can reduce baseline dopamine production
https://youtu.be/QmOF0crdyRU?t=7520
https://youtu.be/QmOF0crdyRU?t=7520
Rhyothemis
in
Cure Parkinson's
3 years ago
Ellfindoe and LotteM please ....
Thank you to Ellfindoe for being patient and explaining so well. I hope you don’t mind, but I have taken what you have said and put it in my own words to try to ensure that I understand what you have said. Here goes ….. The latest model of RLS is that there is a series of factors which lead to RLS
Thank you to Ellfindoe for being patient and explaining so well. I hope you don’t mind, but I have taken what you have said and put it in my own words to try to ensure that I understand what you have said. Here goes ….. The latest model of RLS is that there is a series of factors which lead to RLS
67Waterman
in
Restless Legs Syndrome
3 years ago
Increasing Dopamine receptor density?
Found randomly on the net : "There is a very powerful way to upregulate your dopamine receptor density, among other things, and it involves abstaining from sexual behaviours of any kind. Particularly self-pleasure and pornography watching. Fasting is another way. Any prolonged reduction of dopamine release
Found randomly on the net : "There is a very powerful way to upregulate your dopamine receptor density, among other things, and it involves abstaining from sexual behaviours of any kind. Particularly self-pleasure and pornography watching. Fasting is another way. Any prolonged reduction of dopamine release
Xenos
in
Cure Parkinson's
3 years ago
Parkinson's is not all in your head: Frozen Shoulder
I saw this picture the other day while researching frozen shoulder. It really hit me that PD is always described as problems being caused by dopamine cells dying in your brain and the subsequent lack of dopamine affecting your body. If you look at this picture and see the difference between the normal
I saw this picture the other day while researching frozen shoulder. It really hit me that PD is always described as problems being caused by dopamine cells dying in your brain and the subsequent lack of dopamine affecting your body. If you look at this picture and see the difference between the normal
Bolt_Upright
in
Cure Parkinson's
3 years ago
Parkinson's Disease - Hydrogen & Dopamine discussion with Dr. Joerg Birkmeyer and Mark Kent 11/26/2021
Parkinson's Disease - Hydrogen & Dopamine discussion with Dr. Joerg Birkmeyer and Mark Kent 11/26/2021 - https://youtu.be/py20sLqHeFs We discuss the relationship between hydrogen gas, L-Dopa, Dopamine and and how hydrogen producing bacteria can be the root cause of Parkinson's Disease and potential new
Parkinson's Disease - Hydrogen & Dopamine discussion with Dr. Joerg Birkmeyer and Mark Kent 11/26/2021 - https://youtu.be/py20sLqHeFs We discuss the relationship between hydrogen gas, L-Dopa, Dopamine and and how hydrogen producing bacteria can be the root cause of Parkinson's Disease and potential new
Bolt_Upright
in
Cure Parkinson's
3 years ago
Clarification needed please Ellfindoe, Joolsg and others
I still struggle with the fact that RLS absolutely responds to Ropinirole, which is a dopamine-receptor agonist, but then we are told no to that, and are advised to take Gabapentin, which is an anticonvulsant medication. Stupid question but is that telling me that lack of dopamine causes the nerves
I still struggle with the fact that RLS absolutely responds to Ropinirole, which is a dopamine-receptor agonist, but then we are told no to that, and are advised to take Gabapentin, which is an anticonvulsant medication. Stupid question but is that telling me that lack of dopamine causes the nerves
67Waterman
in
Restless Legs Syndrome
3 years ago
The Ultimate Guide to Increasing Dopamine Naturally
Saw this link on FB. Seems like solid foundational advice: The Ultimate Guide to Increasing Dopamine Naturally https://www.vitamonk.com/blogs/health/natural-ways-to-boost-dopamine It's not geared towards PD. Lot's of reference links at the end.
Saw this link on FB. Seems like solid foundational advice: The Ultimate Guide to Increasing Dopamine Naturally https://www.vitamonk.com/blogs/health/natural-ways-to-boost-dopamine It's not geared towards PD. Lot's of reference links at the end.
Bolt_Upright
in
Cure Parkinson's
3 years ago
Anyone used Vitex (Agnus castus/chasteberry) and did it help or aggravate RLS?
Having heavy n prolonged periods so was researching solutions. Came across Vitex (to balance out hormones) but no idea if it's safe for RLS because when I googled Vitex RLS I read something about it affecting dopamine receptors? Has anyone used this for their periods or any other issue, or can advise
Having heavy n prolonged periods so was researching solutions. Came across Vitex (to balance out hormones) but no idea if it's safe for RLS because when I googled Vitex RLS I read something about it affecting dopamine receptors? Has anyone used this for their periods or any other issue, or can advise
ejaji
in
Restless Legs Syndrome
3 years ago
Supplementing Dopamine
If a person has symptoms of a dopamine deficit at any time throughout the day, is there any way to boost or supplement it without rx meds? I have adhd and rls. I don’t take stimulant meds because of age and hx of cardiac issues. I take gabapentin 600 mg at bedtime for rls. Occasionally I have to take
If a person has symptoms of a dopamine deficit at any time throughout the day, is there any way to boost or supplement it without rx meds? I have adhd and rls. I don’t take stimulant meds because of age and hx of cardiac issues. I take gabapentin 600 mg at bedtime for rls. Occasionally I have to take
JLBowman
in
Restless Legs Syndrome
3 years ago
Looking for the best supplement for pcos ?
Look no further , are you struggling on metformin ? , just taking Myo inositol ? Or maybe your not taking anything for your insulin resistance ? Let me introduce you to my lil friend, Inositol is a brilliant supplement. Inositol influences the action of insulin, a hormone essential for blood sugar control
Look no further , are you struggling on metformin ? , just taking Myo inositol ? Or maybe your not taking anything for your insulin resistance ? Let me introduce you to my lil friend, Inositol is a brilliant supplement. Inositol influences the action of insulin, a hormone essential for blood sugar control
Carly93
in
PCOS UK (Verity)
3 years ago
leukemia drug nilotinib could halt the progression of motor- and non-motor-related symptoms in Parkinson’s disease.
Specifically, they discovered that the 300-mg dose of nilotinib reversed these effects by inactivating a protein called DDR1 that affects the ability of the blood-brain barrier to function correctly. On the inhibition of DDR1 by nilotinib, the normal transportation of molecules in and out of the brain
Specifically, they discovered that the 300-mg dose of nilotinib reversed these effects by inactivating a protein called DDR1 that affects the ability of the blood-brain barrier to function correctly. On the inhibition of DDR1 by nilotinib, the normal transportation of molecules in and out of the brain
JustJeff
in
Cure Parkinson's
3 years ago
"A change in diet may reduce risk of lethal prostate cancer" Your thoughts on the study results below?
What do you all think of these findings, particularly regarding the foods listed? Some of them are known to be heathy, such as: fish, beans, nuts, pulses, spinach and beets! Also - What if you already have aggressive prostate cancer, then does eating the less lethal food, mentioned below, become less
What do you all think of these findings, particularly regarding the foods listed? Some of them are known to be heathy, such as: fish, beans, nuts, pulses, spinach and beets! Also - What if you already have aggressive prostate cancer, then does eating the less lethal food, mentioned below, become less
GeorgeGlass
in
Advanced Prostate Cancer
3 years ago
Has anyone in the US taken a long time to have their RLS diagnosed?
Has anyone in the US taken a long time to have their RLS diagnosed and then was put on a dopamine agonist which eventually resulted in augmentation? The reason I ask is there is a feature in the weekly Health section of the Washington Post called Medical Mysteries. It would be great to have one done
Has anyone in the US taken a long time to have their RLS diagnosed and then was put on a dopamine agonist which eventually resulted in augmentation? The reason I ask is there is a feature in the weekly Health section of the Washington Post called Medical Mysteries. It would be great to have one done
SueJohnson
in
Restless Legs Syndrome
3 years ago
My Dislike For Lyrica Grows by The Day
I also dislike mysteries. I like understanding. The other day a member posted that the first time he ever had RLS in his 30 years of life was shortly after he went cold turkey off of Pregabalin, which he was taking for other reasons. It absolutely has the tendency to do this. I will post case reports
I also dislike mysteries. I like understanding. The other day a member posted that the first time he ever had RLS in his 30 years of life was shortly after he went cold turkey off of Pregabalin, which he was taking for other reasons. It absolutely has the tendency to do this. I will post case reports
Hidden
in
Restless Legs Syndrome
3 years ago
Reference to the updated "Algorithm" for RLS treatment
Here is the reference and link to the updated "Algorithm" for RLS treatment. It's worth bringing the reference to your GP, neurologist and sleep specialist Silber, Michael H., Mark J. Buchfuhrer, Christopher J. Earley, Brian B. Koo, Mauro Manconi, John W. Winkelman, Christopher J. Earley, et al. “The
Here is the reference and link to the updated "Algorithm" for RLS treatment. It's worth bringing the reference to your GP, neurologist and sleep specialist Silber, Michael H., Mark J. Buchfuhrer, Christopher J. Earley, Brian B. Koo, Mauro Manconi, John W. Winkelman, Christopher J. Earley, et al. “The
GuillaumeL
in
Restless Legs Syndrome
3 years ago
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