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Phase 1/2 of TLX592 Targeted Alpha Therapy in Prostate Cancer starting soon - Ac 225
"The approach accelerates blood clearance and reduces bone marrow residence time compared with standard monoclonal antibodies (mAbs), while retaining target selectivity, internalisation and retention." https://www.prnewswire.com/news-releases/telix-completes-proof-of-concept-study-of-tlx592-targeted-alpha-therapy-in-prostate-cancer
"The approach accelerates blood clearance and reduces bone marrow residence time compared with standard monoclonal antibodies (mAbs), while retaining target selectivity, internalisation and retention." https://www.prnewswire.com/news-releases/telix-completes-proof-of-concept-study-of-tlx592-targeted-alpha-therapy-in-prostate-cancer
Maxone73
in
Advanced Prostate Cancer
1 month ago
Psychological and fitness assessment form
Hi, I’m filling in my transplant assessment form for a meeting in a few weeks time and some of the questions seem vague. There is a question regarding how healthy I feel today with a scale from 1 to 10 ( eq5d ). Does this refer to mental, physical or general health ? Also , if you say you feel too
Hi, I’m filling in my transplant assessment form for a meeting in a few weeks time and some of the questions seem vague. There is a question regarding how healthy I feel today with a scale from 1 to 10 ( eq5d ). Does this refer to mental, physical or general health ? Also , if you say you feel too
Bootsforlife
in
British Liver Trust
1 month ago
borderline renal function, my MD cut my Nubeqa in half--thoughts?
Borderline renal function, mets to pelvis, and multiple lymph nodes in lungs, but seen only on PET, not on MRI . age 83
Borderline renal function, mets to pelvis, and multiple lymph nodes in lungs, but seen only on PET, not on MRI . age 83
Sweetjessie
in
Advanced Prostate Cancer
1 month ago
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Ped5i/Tadalafil etc as a benefit to SE of ADT?
Tadalafil , etc is prescribed for ED, BPH and PAH (pulmonary arterial hypertension). It is pretty much agreed upon that Tadalafil increases insulin sensitivity thus improving lean body mass, particularly around the gut, improves Testosterone/estrogen relationship and is good for heart and vascular health
Tadalafil , etc is prescribed for ED, BPH and PAH (pulmonary arterial hypertension). It is pretty much agreed upon that Tadalafil increases insulin sensitivity thus improving lean body mass, particularly around the gut, improves Testosterone/estrogen relationship and is good for heart and vascular health
pj1121
in
Advanced Prostate Cancer
1 month ago
Firmagon vs Lupron
So, the question is what are the up or downs if switching from Firmagon to Lupron. I used Orgovyx until it didn't work, switched to Firmagon. Wanted either due to family history with heart issues. Dad, uncle's, brothers, all having issues. One brother recently having a major HA... But the convenience
So, the question is what are the up or downs if switching from Firmagon to Lupron. I used Orgovyx until it didn't work, switched to Firmagon. Wanted either due to family history with heart issues. Dad, uncle's, brothers, all having issues. One brother recently having a major HA... But the convenience
Cooolone
in
Advanced Prostate Cancer
5 months ago
THC , CBD
hi During my annual swaree down to South Africa , I came across a health guru, advised Me to try THC , the only problem is I’m about to finish my small bottle , I’ve been putting couple of drops under my tongue when my off period starts after madopar , why are we so stuck up in the uk , with all these
hi During my annual swaree down to South Africa , I came across a health guru, advised Me to try THC , the only problem is I’m about to finish my small bottle , I’ve been putting couple of drops under my tongue when my off period starts after madopar , why are we so stuck up in the uk , with all these
Troongolfer
in
Cure Parkinson's
1 month ago
Kidney stones?
Morning everyone, just wondered if anyone has had kidney stones. I have been experiencing pain in my left groin and lower back and side for a few weeks. It wakes me up at night and l get it intermittently through the day. The doctor thinks it maybe Arthritis and l am getting a xray on Thursday. What
Morning everyone, just wondered if anyone has had kidney stones. I have been experiencing pain in my left groin and lower back and side for a few weeks. It wakes me up at night and l get it intermittently through the day. The doctor thinks it maybe Arthritis and l am getting a xray on Thursday. What
70michael
in
Lung Conditions Community Forum
1 month ago
Saline nasal rinse and glaucoma
I suffer with allergies and used to use steroid nasal spray. Now I have glaucoma I now know that these sprays are bad news! I've been looking into saline nasal rinse kits as an alternative to help me with the chronic catarrh in my throat but can't see any information about if these are safe to use for
I suffer with allergies and used to use steroid nasal spray. Now I have glaucoma I now know that these sprays are bad news! I've been looking into saline nasal rinse kits as an alternative to help me with the chronic catarrh in my throat but can't see any information about if these are safe to use for
Bonniecat7
in
Glaucoma UK
5 months ago
Redefining Parkinson's Disease | Kathleen Poston Podcast
I seldom listen to podcasts. I was never sure why. Eventually decided it was just too hard to retain new information. But this one should stay in my brain. She talks about the triad of symptoms that define PD: 1. Bradykinesia 2. Stiffness and 3. Tremor. And then the dozen of other
I seldom listen to podcasts. I was never sure why. Eventually decided it was just too hard to retain new information. But this one should stay in my brain. She talks about the triad of symptoms that define PD: 1. Bradykinesia 2. Stiffness and 3. Tremor. And then the dozen of other
kaypeeoh
in
Cure Parkinson's
1 month ago
edoxaban or rivaroxaban?
I have been on Lixiana (Edoxaban) since my AF diagnosis just over two years ago and have had no issues at all with it. After my last request for a repeat prescription I got a phone call today from the doctor saying that the blood test I had last August (!) revealed a slight decrease in kidney function
I have been on Lixiana (Edoxaban) since my AF diagnosis just over two years ago and have had no issues at all with it. After my last request for a repeat prescription I got a phone call today from the doctor saying that the blood test I had last August (!) revealed a slight decrease in kidney function
Sandych55
in
Atrial Fibrillation Support
5 months ago
Mikemike
Hello....I am here and happy to help in any way I can. Will try to be concise. G-9...radiation only(28 sessions IMRT) a breeze. Declined lupron...because of a continuing anxiety condition. Metastices showed up 14 most later...PSA 6.7 up to 16.2 in 6 weeks. PSMA pet showed two rib mets and 1 other on
Hello....I am here and happy to help in any way I can. Will try to be concise. G-9...radiation only(28 sessions IMRT) a breeze. Declined lupron...because of a continuing anxiety condition. Metastices showed up 14 most later...PSA 6.7 up to 16.2 in 6 weeks. PSMA pet showed two rib mets and 1 other on
Poppy1952
in
Advanced Prostate Cancer
1 month ago
Discoid Lupus
Hello Everyone, I have been suffering with discoid lupus for 5 years now. i have had some pretty nasty flare ups since being diagnosed. One flare up resulted in having to spend 2 weeks in hospital. I recently had another flare up… After nearly 12 months in remission… And I started to get bald patches
Hello Everyone, I have been suffering with discoid lupus for 5 years now. i have had some pretty nasty flare ups since being diagnosed. One flare up resulted in having to spend 2 weeks in hospital. I recently had another flare up… After nearly 12 months in remission… And I started to get bald patches
Beryl2485
in
LUPUS UK
6 months ago
got tested
hello, today I got following tests, ast, alt, bilirubin, ggt, leuktocytes, hemoglobin and all were normal now . then I assume that my so-called symptoms are not due to decompensated liver cirrhosis.. or how were your blood tests at diagnosis/symptoms (fatigue, spider nevi)(?) ☀️☀️
hello, today I got following tests, ast, alt, bilirubin, ggt, leuktocytes, hemoglobin and all were normal now . then I assume that my so-called symptoms are not due to decompensated liver cirrhosis.. or how were your blood tests at diagnosis/symptoms (fatigue, spider nevi)(?) ☀️☀️
Spider2
in
British Liver Trust
1 month ago
Liver Ultrasound Question
Hello! I had an abdominal ultrasound today including my liver due to a recent blood test showing very high on all the liver tests… my GP is suspecting Non-alcoholic fatty liver… I know I have to wait for the ultrasound report to come back, but the radiologist who did the scan said that my liver was
Hello! I had an abdominal ultrasound today including my liver due to a recent blood test showing very high on all the liver tests… my GP is suspecting Non-alcoholic fatty liver… I know I have to wait for the ultrasound report to come back, but the radiologist who did the scan said that my liver was
Hidden
in
British Liver Trust
6 months ago
Failed Trabeculectomy
Hi!I have a failed trabeculectomy. 😢 Operated June 2022 with pressure of 16. Too high so 2 stitches were taken out and then pressure dropped to 2 and wouldn't come up so had to add a stitch to the bleb going through the conjunctiva. Pressure remained at about 11 for 9 months then then the bleb heal
Hi!I have a failed trabeculectomy. 😢 Operated June 2022 with pressure of 16. Too high so 2 stitches were taken out and then pressure dropped to 2 and wouldn't come up so had to add a stitch to the bleb going through the conjunctiva. Pressure remained at about 11 for 9 months then then the bleb heal
stephanie1977
in
Glaucoma UK
5 months ago
Utis and clear urine.
I dont think conventional wisdom is the answer to my question.Every six weeks i get my sp catheter changed. When the doc changed it in the cystoscopy room, twice i had clear urine and no utis. Anywhere else with that doc or nurse, i get utis and or muddy urine. I say the air is filtered better in that
I dont think conventional wisdom is the answer to my question.Every six weeks i get my sp catheter changed. When the doc changed it in the cystoscopy room, twice i had clear urine and no utis. Anywhere else with that doc or nurse, i get utis and or muddy urine. I say the air is filtered better in that
Tempa
in
Men's Health Forum
1 month ago
Advise on these pictures please?
Hi everyone. I’m 25 years old and was a heavy drinker from 2018 - February this year. I’ve quite drinking vodka and other alcohol completely since then. Due to the alcohol my stools haven’t really been normal for years and I don’t particularly have a great diet either. At the moment I’m drinking too
Hi everyone. I’m 25 years old and was a heavy drinker from 2018 - February this year. I’ve quite drinking vodka and other alcohol completely since then. Due to the alcohol my stools haven’t really been normal for years and I don’t particularly have a great diet either. At the moment I’m drinking too
DontTrustGoogle
in
Colon Cancer Connected
9 months ago
Jevtana
Once again I am asking for any information that can be provided from this great group. Would appreciate any information for Jevtana treatment. At doctor's appt yesterday, my husband's hemoglobin had decreased to 7.6 and he had to have a blood transfusion. His Alkaline Phosphatase went up again. He
Once again I am asking for any information that can be provided from this great group. Would appreciate any information for Jevtana treatment. At doctor's appt yesterday, my husband's hemoglobin had decreased to 7.6 and he had to have a blood transfusion. His Alkaline Phosphatase went up again. He
MsHope
in
Advanced Prostate Cancer
1 month ago
Targeting the glutamine metabolism to suppress cell proliferation in mesenchymal docetaxel-resistant prostate cancer
Source Link : https://www.nature.com/articles/s41388-024-03059-4 Docetaxel (DX) serves as a palliative treatment option for metastatic prostate cancer (PCa). Despite initial remission, acquired DX resistance is inevitable. The mechanisms behind DX resistance have not yet been deciphered, but a mesenchymal
Source Link : https://www.nature.com/articles/s41388-024-03059-4 Docetaxel (DX) serves as a palliative treatment option for metastatic prostate cancer (PCa). Despite initial remission, acquired DX resistance is inevitable. The mechanisms behind DX resistance have not yet been deciphered, but a mesenchymal
God_Loves_Me
in
Advanced Prostate Cancer
1 month ago
GP appointment and blood tests - will recent steroid injection skew results?
Afternoon everyone, I had a GP appointment yesterday to discuss my symptoms. Went through everything that has happened since the summer. She sent me for blood tests today which included CRP, ESR, Rheumatoid factor and various other tests relating to autoimmune conditions. She insisted I call back for
Afternoon everyone, I had a GP appointment yesterday to discuss my symptoms. Went through everything that has happened since the summer. She sent me for blood tests today which included CRP, ESR, Rheumatoid factor and various other tests relating to autoimmune conditions. She insisted I call back for
MsWhistledown
in
PMRGCAuk
6 months ago
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