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BTK Degrader Shows Potential for Treating Refractory CLL and SLL
A novel Bruton's tyrosine kinase (BTK) degrader, NX-2127, has shown potential for treating patients with double- and triple-refractory CLL or SLL who have experienced disease progression while on any covalent or non-covalent BTK inhibitor, as well as a BCL2 inhibitor. NX-2127 a BTK degrader has a novel
A novel Bruton's tyrosine kinase (BTK) degrader, NX-2127, has shown potential for treating patients with double- and triple-refractory CLL or SLL who have experienced disease progression while on any covalent or non-covalent BTK inhibitor, as well as a BCL2 inhibitor. NX-2127 a BTK degrader has a novel
Jm954
Administrator
in
CLL Support
1 year ago
10 Year Anniversary
A few weeks ago I realized this is the ten-year anniversary of when I started dialysis. I started in August of 2013 in the days after I had a knee surgery. I was 14 years old. I'm now 24 years old. In the time since I started dialysis I started and finished high school, started and finished college,
A few weeks ago I realized this is the ten-year anniversary of when I started dialysis. I started in August of 2013 in the days after I had a knee surgery. I was 14 years old. I'm now 24 years old. In the time since I started dialysis I started and finished high school, started and finished college,
StormCl0ud
in
Kidney Dialysis
1 year ago
Update on pain management.
Hi I've seen my orthopaedic consultant and he has arranged an MRI scan for my back and also writing to my GP about my pain medication, that I need some more.Also went to pain management consult who has arranged some injections into my lo wer back..she didn't seem interested in putting me back on strong
Hi I've seen my orthopaedic consultant and he has arranged an MRI scan for my back and also writing to my GP about my pain medication, that I need some more.Also went to pain management consult who has arranged some injections into my lo wer back..she didn't seem interested in putting me back on strong
Mauimags
in
Pain Concern
1 year ago
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absolutely a joke pip
long story with nerve pain endo nerve pain and endometriosis pain everywhere everyday operations constant scars , bladder bowel issues physical therapy, bipolar depression and I get zero points , on opioids painkillers everyday no justice for endo warriors but people can get pip with fuck all wrong with
long story with nerve pain endo nerve pain and endometriosis pain everywhere everyday operations constant scars , bladder bowel issues physical therapy, bipolar depression and I get zero points , on opioids painkillers everyday no justice for endo warriors but people can get pip with fuck all wrong with
Lynnsashalily
in
Endometriosis UK
1 year ago
tortuous world of pain
It seems counter-intuitive and unfair that person addicted to opiates can obtain buprenorphine at a constant prescribed dose, to enable them to live a 'productive' life, (read Employed), whereas the person in
chronic
pain
is denied the same drug, due to fears of addiction.
It seems counter-intuitive and unfair that person addicted to opiates can obtain buprenorphine at a constant prescribed dose, to enable them to live a 'productive' life, (read Employed), whereas the person in
chronic
pain
is denied the same drug, due to fears of addiction.
Hidden
in
Neuropathy Support
8 months ago
9 weeks post op, still pain on one side, dark shade around kidney? Also new endometrioma found 😔
So at 6 weeks I posted about pain to one side, I was finally send to SAU yesterday for bloods and an ultrasound, my back is so tender to touch and they have found a dark spot in my kidney area? They don't know what it is but sent me home with a lot of pain killers and the promise of a CT scan to take
So at 6 weeks I posted about pain to one side, I was finally send to SAU yesterday for bloods and an ultrasound, my back is so tender to touch and they have found a dark spot in my kidney area? They don't know what it is but sent me home with a lot of pain killers and the promise of a CT scan to take
Pinkybow
in
Endometriosis UK
1 year ago
NHS Attitudes on Worth of Life
My deep apologies to everyone for this post but I think it’s going to be a long one. Partly about PA and partly on NHS attitudes I am encountering about the worth of life. Warning for sensitive members, this post might be shocking. So you will know me through my posts regarding seizures and both neurological
My deep apologies to everyone for this post but I think it’s going to be a long one. Partly about PA and partly on NHS attitudes I am encountering about the worth of life. Warning for sensitive members, this post might be shocking. So you will know me through my posts regarding seizures and both neurological
RoseFlowerDew
in
Pernicious Anaemia Society
1 year ago
A three year journey to find the right medication
This illness is awful and very few healthy people understand the burden of fatigue and
chronic
pain
.
This illness is awful and very few healthy people understand the burden of fatigue and
chronic
pain
.
Greencat96
in
NRAS
10 months ago
Has this happened to you?
2 weeks post mechanical valve and aorta replacement, recovering ok even after contracting pneumonia in hospital day 2, home 1 week and taking my 5m warfarin as prescribed and some painkillers but less and less every day, going to anticoag clinic twice a week but the long weekend meant an extra day without
2 weeks post mechanical valve and aorta replacement, recovering ok even after contracting pneumonia in hospital day 2, home 1 week and taking my 5m warfarin as prescribed and some painkillers but less and less every day, going to anticoag clinic twice a week but the long weekend meant an extra day without
Pefki
in
British Heart Foundation
1 year ago
husband diagnosed with cardiovascular disease
pain
thanks for taking the time Nat xx
pain
thanks for taking the time Nat xx
Natsteveo
in
British Heart Foundation
1 year ago
stiffness
I also have calcific tendinitis on my hip and shoulders and the restrictions it gives me to stretch my body without
pain
is
chronic
and makes my hip so painful to walk ,Is this familiar to anyone ?
I also have calcific tendinitis on my hip and shoulders and the restrictions it gives me to stretch my body without
pain
is
chronic
and makes my hip so painful to walk ,Is this familiar to anyone ?
Luckylady1978
in
Fibromyalgia Action UK
9 months ago
Back pain, still no answer
I received my results from some of the blood work I had done. I’m still trying to figure out why I have such excruciating back pain. So far, I have no answer. I usually don’t get relief from the pain pills better than a 6 on the scale of 1-10. I have to wait until I get a little relief to be able to
I received my results from some of the blood work I had done. I’m still trying to figure out why I have such excruciating back pain. So far, I have no answer. I usually don’t get relief from the pain pills better than a 6 on the scale of 1-10. I have to wait until I get a little relief to be able to
Amore55
in
My MSAA Community
1 year ago
Chronic pain and hypothyroidism - ideas? Will NDT eventually bring relief?
I've been suffering with
chronic
pain
in my back shoulders and neck on and off for about 18 months and have had pain issues for most of my adult life.
I've been suffering with
chronic
pain
in my back shoulders and neck on and off for about 18 months and have had pain issues for most of my adult life.
fpardoe
in
Thyroid UK
1 year ago
IBS-C with chronic constipation and abdominal pain at night.
I was prescribed Constella (linzess) and it helped really well for a while. Now it seems to do nothing for me. Anyone else had this experience?
I was prescribed Constella (linzess) and it helped really well for a while. Now it seems to do nothing for me. Anyone else had this experience?
Hennen
in
IBS Network
5 months ago
CLL Webinar
Hi all Here is the link for today's CLL webinar. This educational webinar will give an overview of how CLL is treated today and the significance of ’hot topics’ and key treatment development advances published and discussed at 2022 international hematology conferences. What is new and what does this
Hi all Here is the link for today's CLL webinar. This educational webinar will give an overview of how CLL is treated today and the significance of ’hot topics’ and key treatment development advances published and discussed at 2022 international hematology conferences. What is new and what does this
Irishcll
in
CLL Support
1 year ago
Knee injury - sigh.
Started my running journey around five years ago and I've been going through a real purple patch recently as have clocked up two personal bests for the 5k and have generally been running faster and at a consistent pace (always conversational - I checked that by muttering to myself every so often!).
Started my running journey around five years ago and I've been going through a real purple patch recently as have clocked up two personal bests for the 5k and have generally been running faster and at a consistent pace (always conversational - I checked that by muttering to myself every so often!).
Crolla
in
Couch to 5K
1 year ago
Not positive but not negative?
I’ve just had a Day 5 FET and my hcg has come back at 17 on my first blood test. So it’s a wait and see! We have never gotten out the start gate before so I don’t know whether to be too hopeful or not. Has anyone had similar and had a good outcome? I’m 43 so I bit scared to get any kind of excited.
I’ve just had a Day 5 FET and my hcg has come back at 17 on my first blood test. So it’s a wait and see! We have never gotten out the start gate before so I don’t know whether to be too hopeful or not. Has anyone had similar and had a good outcome? I’m 43 so I bit scared to get any kind of excited.
winningreid
in
Fertility Network UK
7 months ago
bowel issue
hello, I posted before and should of mentioned this also that every time I open my bowels I have to take a painkiller and lie down until it takes affect, as I mentioned before my treatment ended twelve weeks ago, how long will this carry on as I am going to have to become employed again and I don’t know
hello, I posted before and should of mentioned this also that every time I open my bowels I have to take a painkiller and lie down until it takes affect, as I mentioned before my treatment ended twelve weeks ago, how long will this carry on as I am going to have to become employed again and I don’t know
Emiliejo
in
Pelvic Radiation Disease Association
1 year ago
Common Symptoms.
I find it helpful when someone posts or replies with a symptom not included in the medical field's list that I do experience. Often with the comment I used to have this symptom prior to treatment. When Trigeminal neuralgia was mentioned a light went on for me and it was helpful to have a name for what
I find it helpful when someone posts or replies with a symptom not included in the medical field's list that I do experience. Often with the comment I used to have this symptom prior to treatment. When Trigeminal neuralgia was mentioned a light went on for me and it was helpful to have a name for what
WIZARD6787
in
Pernicious Anaemia Society
1 year ago
Slow rising HCG - bleeding and clots - ivf
Hi. I had a FET on 20/09. Tested positive on 02/10 with hcg blood reading of 592. Started spotting on 06/10 which has got progressively heavier - like a period and shedding lining. Went to EPAU today and nothing detected on scan but per transfer would be 5+3 and too early to detect anyway. My bloods
Hi. I had a FET on 20/09. Tested positive on 02/10 with hcg blood reading of 592. Started spotting on 06/10 which has got progressively heavier - like a period and shedding lining. Went to EPAU today and nothing detected on scan but per transfer would be 5+3 and too early to detect anyway. My bloods
Toffeepudding99
in
Fertility Network UK
7 months ago
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