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It’s official Study shows T cells are activated against Covid after vaccination
Just heard on the Irish Radio from Professor Luke O’Neill, a super immunologist in Trinity College Dublin, results of a study on Leukemia patients show T Cells show response to the vaccine. Sorry I can’t remember the name of the study he mentioned . Great news he thought. It’s nature.com and Eureka
Just heard on the Irish Radio from Professor Luke O’Neill, a super immunologist in Trinity College Dublin, results of a study on Leukemia patients show T Cells show response to the vaccine. Sorry I can’t remember the name of the study he mentioned . Great news he thought. It’s nature.com and Eureka
Hidden
in
CLL Support
3 years ago
HCG stalled around 300, slowly rising
Has anyone had this happen? My doctor is not letting me stop the medications yet. He says he is "not optimistic but we have to wait and see." I had both my tubes removed but he said we still cannot rule out an ectopic pregnancy. I am shocked that I am still being treated as if there is a miniscule chance
Has anyone had this happen? My doctor is not letting me stop the medications yet. He says he is "not optimistic but we have to wait and see." I had both my tubes removed but he said we still cannot rule out an ectopic pregnancy. I am shocked that I am still being treated as if there is a miniscule chance
LuxFleur
in
Fertility Network UK
3 years ago
First results of a head-to-head trial of acalabrutinib versus ibrutinib in previously treated chronic lymphocytic leukemia.
Background: Increased selectivity of the Bruton tyrosine kinase inhibitor (BTKi) acalabrutinib (Aca) vs ibrutinib (Ib) may improve tolerability. We conducted an open-label, randomized, noninferiority, phase 3 trial to compare Aca vs Ib in patients (pts) with chronic lymphocytic leukemia (CLL). Methods
Background: Increased selectivity of the Bruton tyrosine kinase inhibitor (BTKi) acalabrutinib (Aca) vs ibrutinib (Ib) may improve tolerability. We conducted an open-label, randomized, noninferiority, phase 3 trial to compare Aca vs Ib in patients (pts) with chronic lymphocytic leukemia (CLL). Methods
Jm954
Administrator
in
CLL Support
3 years ago
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CLL: from molecular pathogenesis to novel therapeutic strategies
September 2020 An interesting paper "CLL is a well-defined lymphoid neoplasm with very heterogeneous biological and clinical behavior. The last decade has been remarkably fruitful in novel findings elucidating multiple aspects of the pathogenesis of the disease. These include mechanisms of genetic susceptibility
September 2020 An interesting paper "CLL is a well-defined lymphoid neoplasm with very heterogeneous biological and clinical behavior. The last decade has been remarkably fruitful in novel findings elucidating multiple aspects of the pathogenesis of the disease. These include mechanisms of genetic susceptibility
Jm954
Administrator
in
CLL Support
3 years ago
Screening and monitoring of the BTK C481S mutation in a real-world cohort of patients with relapsed/refractory chronic lymphocytic leukaemia
On line abstract report 21 May 2021 The Bruton's tyrosine kinase (BTK) inhibitor ibrutinib has revolutionised the therapeutic landscape of chronic lymphocytic leukaemia (CLL). Acquired mutations emerging at position C481 in the BTK tyrosine kinase domain are the predominant genetic alterations associated
On line abstract report 21 May 2021 The Bruton's tyrosine kinase (BTK) inhibitor ibrutinib has revolutionised the therapeutic landscape of chronic lymphocytic leukaemia (CLL). Acquired mutations emerging at position C481 in the BTK tyrosine kinase domain are the predominant genetic alterations associated
Jm954
Administrator
in
CLL Support
3 years ago
Low progesterone
So I got my BFP from an NHS FET on Sunday woohoo! I am on oestrogen (elleste) and progesterone (utrogestan 200mg x3 a day) with them. I have also been having my immune system treated with a private clinic. The day of my transfer the private clinic tested my progesterone and said it was low adding 1 Lubion
So I got my BFP from an NHS FET on Sunday woohoo! I am on oestrogen (elleste) and progesterone (utrogestan 200mg x3 a day) with them. I have also been having my immune system treated with a private clinic. The day of my transfer the private clinic tested my progesterone and said it was low adding 1 Lubion
GJW2018
in
Fertility Network UK
3 years ago
News - Acalabrutinib approved for Restricted use in Scotland
Following an abbreviated and full submissions, the Scottish Medicines Consortium has approved Acalabrutinib for CLL with the following restrictions:
[i]*for the treatment of adult patients with previously untreated CLL without a del(17p) or TP53 mutation and who are [/i]
[i][u]ineligible[/
Following an abbreviated and full submissions, the Scottish Medicines Consortium has approved Acalabrutinib for CLL with the following restrictions:
[i]*for the treatment of adult patients with previously untreated CLL without a del(17p) or TP53 mutation and who are [/i]
[i][u]ineligible[/
Jm954
Administrator
in
CLL Support
3 years ago
Questioning Cluster Headaches - Is it possible to get them with less severe pain?
Hi all, Earlier this year for about 6 weeks I had recurrent headaches that felt like bad pain behind and around my right eye. They would happen multiple times a day but not last too long - between 30 mins and 3 hours. They they went away so I thought it was just a strange thing but it was gone and didn't
Hi all, Earlier this year for about 6 weeks I had recurrent headaches that felt like bad pain behind and around my right eye. They would happen multiple times a day but not last too long - between 30 mins and 3 hours. They they went away so I thought it was just a strange thing but it was gone and didn't
WheezyZebra
in
National Migraine Centre
3 years ago
Hcg not rising enough
I am feeling quite shattered. I got my bfp on 26/7 with hcg of 217. Got repeat bloods one week later. Hcg 930. Nurse says they are very concerned as the rate of rise is not enough. So to hope for the best but plan for the worst. I have repeat bloods on Thursday morning. This was our last chance with
I am feeling quite shattered. I got my bfp on 26/7 with hcg of 217. Got repeat bloods one week later. Hcg 930. Nurse says they are very concerned as the rate of rise is not enough. So to hope for the best but plan for the worst. I have repeat bloods on Thursday morning. This was our last chance with
Eggbabe
in
Fertility Network UK
3 years ago
Acupuncture success anyone?
Hi all, has anyone benefitted from acupuncture? I had my first session last week, mostly on one especially painful arm and one leg. I know we obviously hurt all over, but I'm starting small. 🙄 I had bad headaches and nausea that evening, but prepared to do a 6 week course if it will help?
Hi all, has anyone benefitted from acupuncture? I had my first session last week, mostly on one especially painful arm and one leg. I know we obviously hurt all over, but I'm starting small. 🙄 I had bad headaches and nausea that evening, but prepared to do a 6 week course if it will help?
Janpan7
in
Fibromyalgia Action UK
3 years ago
ET CALR
Hi guys! I am feeling anxious tonight. I have some question for you. Is it anybody Who has ET with CALR and had it for a long time and not progressed to MF? You guys who has MF and CALR, for how long have you had it? Im getting my first bmb in july. Right now i am CALR ET, my blood shows platelets
Hi guys! I am feeling anxious tonight. I have some question for you. Is it anybody Who has ET with CALR and had it for a long time and not progressed to MF? You guys who has MF and CALR, for how long have you had it? Im getting my first bmb in july. Right now i am CALR ET, my blood shows platelets
Johan2021
in
MPN Voice
3 years ago
Two IVF cycles, two miscarriages—is this good or bad?
So it seems that I am most likely on my way to having my second miscarriage. I got a BFP this week but it does not look good. I've now had two ICSI cycles, both of which resulted in two embryos each. Two transfers per cycle, the second of which resulted in a pregnancy both times. Our first pregnancy
So it seems that I am most likely on my way to having my second miscarriage. I got a BFP this week but it does not look good. I've now had two ICSI cycles, both of which resulted in two embryos each. Two transfers per cycle, the second of which resulted in a pregnancy both times. Our first pregnancy
LuxFleur
in
Fertility Network UK
3 years ago
5 weeks nothing seen on ultrasound
Did IVF and had an ultrasound yesterday with no gestational sac I was exactly 5 weeks yesterday upon scan. Hcg numbers still tripling. First hcg on 7/24- 85 2nd on 7/27- 245 3rd yesterday 7/30- 860 They are saying now that there is a possibility of ectopic pregnancy or maybe too early to scan. Has anyone
Did IVF and had an ultrasound yesterday with no gestational sac I was exactly 5 weeks yesterday upon scan. Hcg numbers still tripling. First hcg on 7/24- 85 2nd on 7/27- 245 3rd yesterday 7/30- 860 They are saying now that there is a possibility of ectopic pregnancy or maybe too early to scan. Has anyone
Raeyamom
in
Fertility Network UK
3 years ago
HCG is not climbing fast enough, only 296 18dp5dt
This is a really hard process. Our doctor was concerned that our HCG was climbing too slowly and that seems to be correct. Here are our numbers: 12dp5dt: 76 14dp5dt: 139 16dp5dt: 227 18dp5dt: 296 I want to ask if there is any hope but it seems like there isn't. EDIT: Since it seems like I will be losing
This is a really hard process. Our doctor was concerned that our HCG was climbing too slowly and that seems to be correct. Here are our numbers: 12dp5dt: 76 14dp5dt: 139 16dp5dt: 227 18dp5dt: 296 I want to ask if there is any hope but it seems like there isn't. EDIT: Since it seems like I will be losing
LuxFleur
in
Fertility Network UK
3 years ago
Anyone here carry to term with own eggs 42+?
I am just feeling worried that this is impossible. I'm 42 and 5w2d, with low and slow HCG. Had a loss in the spring. I'm just feeling like all the over 41 successes I see on here are with DE. Please share if you've had a live birth with own eggs over age 41, thank you xoxo
I am just feeling worried that this is impossible. I'm 42 and 5w2d, with low and slow HCG. Had a loss in the spring. I'm just feeling like all the over 41 successes I see on here are with DE. Please share if you've had a live birth with own eggs over age 41, thank you xoxo
LuxFleur
in
Fertility Network UK
3 years ago
Chronic Constipation
I have been on PD since Jan 2016. Recently, my issues with constipation have gotten to a very frustrating level. I have tried: Prunes; more fruits/veggies; OTC softeners; laxatives; yogurt; probiotics; exercise.....and it is to a chronic stage. If I take prescription Linzess or Trulance provided
I have been on PD since Jan 2016. Recently, my issues with constipation have gotten to a very frustrating level. I have tried: Prunes; more fruits/veggies; OTC softeners; laxatives; yogurt; probiotics; exercise.....and it is to a chronic stage. If I take prescription Linzess or Trulance provided
TaffyTwoshoes27
in
Kidney Dialysis
3 years ago
3rd HCG test, from 139 to 227, worried!!!!!!
Hello, I tested my HCG again today for a third time, on 16dp5dt, and got 227. Has anyone else had a number this low at around this time and ended up with a viable pregnancy? I'm concerned that the rate of growth is slowing. Our first test was 76, then 139, and now 227. Our clinic is NOT replying to us
Hello, I tested my HCG again today for a third time, on 16dp5dt, and got 227. Has anyone else had a number this low at around this time and ended up with a viable pregnancy? I'm concerned that the rate of growth is slowing. Our first test was 76, then 139, and now 227. Our clinic is NOT replying to us
LuxFleur
in
Fertility Network UK
3 years ago
*** Sensitive *** Worried I didn’t have the beta test
Hi All, today I’m 16dp5dt, 5AA blast, fresh cycle, I think my lines are strong but I’m obsessing over not getting the beta test done as I’m now panicking my hcg might not be high enough. Friday was OTD and I got 1-2 weeks on a digital, Monday I got 2-3 wks on a digital. Today I did a FRER and cheapie
Hi All, today I’m 16dp5dt, 5AA blast, fresh cycle, I think my lines are strong but I’m obsessing over not getting the beta test done as I’m now panicking my hcg might not be high enough. Friday was OTD and I got 1-2 weeks on a digital, Monday I got 2-3 wks on a digital. Today I did a FRER and cheapie
Hidden
in
Fertility Network UK
3 years ago
Sudden onset new migraine aura
Good evening I am 57 and have mitral valve leakage and heart palpatations / and I’m sure the most odd rhythm at times! Over the last month I have been getting the most incredible (what I presume to be) migraine auras. - like a kaleidoscope coming in from the side all wiggly wiggly lights different colours
Good evening I am 57 and have mitral valve leakage and heart palpatations / and I’m sure the most odd rhythm at times! Over the last month I have been getting the most incredible (what I presume to be) migraine auras. - like a kaleidoscope coming in from the side all wiggly wiggly lights different colours
Ninjacat
in
National Migraine Centre
3 years ago
CLL Research: Phase 2 CAPTIVATE Study Suggests Role for Fixed-Duration Treatment of CLL/SLL
https://cllpharmacist.com/cll-research-phase-2-captivate-study-suggests-role-for-fixed-duration-treatment-of-cll-sll/ The data in the uMRD cohort of this trial suggest that fixed-duration therapy is feasible in patients who achieve undetectable MRD (uMRD) status. The selection of durations for these
https://cllpharmacist.com/cll-research-phase-2-captivate-study-suggests-role-for-fixed-duration-treatment-of-cll-sll/ The data in the uMRD cohort of this trial suggest that fixed-duration therapy is feasible in patients who achieve undetectable MRD (uMRD) status. The selection of durations for these
WinJ3
in
CLL Support
3 years ago
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