News - Acalabrutinib approved for Restricted use in Scotland

[Jm954]

Following an abbreviated and full submissions, the Scottish Medicines Consortium has approved Acalabrutinib for CLL with the following restrictions:

*for the treatment of adult patients with previously untreated CLL without a del(17p) or TP53 mutation and who are ineligible for fludarabine, cyclophosphamide and rituximab (FCR) therapy

*previously treated CLL patients (has been approved for those who are not eligible for chemoimmunotherapy).

* untreated patients with 17p deletion or TP53 mutations. These are genetic mutations that affect how well current treatments, such as FCR, work.

Evidence presented showed that Acalabrutinib, compared with chlorambucil-obinutuzumab, significantly improved progression-free survival in adults with previously untreated CLL with co-morbidities.

Jackie

[Newdawn Administrator]

Every little ‘win’ is good to hear Jackie and demonstrates a growing appreciation of the changing treatment landscape.

Newdawn

[mrsjsmith]

Well done Jackie.

Colette x

[annmcgowan]

Thank you Jackie, good news.Ann

[bachplayer13]

great news! acalabrutanib has been wonderful for me in the usa. glad other countries are approving it!

[very]

Thank you Jackie.jenny uk

[morepork]

Scots wha hae !! 😁

[Grembold]

Yes, I have had treatment with Rituximab (as it was known then). It was supposed to be taken daily for the rest of my life, but after taking it for a few month it actually crippeled me permanently, and I stopped taking it. However, I think that this was due to being prescribed the same dose as a fully grown man despite me being 4ft 10ins and weighing 40 kilo.

However I rather think that what they are prescribing now is a cleaned up modified version.

[JanChas]

I had Rituximab infusions alongside Chlorambucil tablets the only side effects I had were nausea which I think was caused by the tablets. With this treatment I went into remission for 2 years.