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Colchicine and Inflammation Revisited
Inflammation is one of the two principle drivers of “The Hallmarks of Cancer” which are the common drivers of progression of cancer from initiation to invasion and spread, to developing resistance to treatments and ultimately to end stage metastasis. (The other main driver being genomic instability:
Inflammation is one of the two principle drivers of “The Hallmarks of Cancer” which are the common drivers of progression of cancer from initiation to invasion and spread, to developing resistance to treatments and ultimately to end stage metastasis. (The other main driver being genomic instability:
MateoBeach
in
Advanced Prostate Cancer
1 year ago
Colchicine and Inflammation Reconsidered
Inflammation is one of the two principle drivers of “The Hallmarks of Cancer” which are the common drivers of progression of cancer from initiation to invasion and spread, to developing resistance to treatments and ultimately to end stage metastasis. (The other main driver being genomic instability:
Inflammation is one of the two principle drivers of “The Hallmarks of Cancer” which are the common drivers of progression of cancer from initiation to invasion and spread, to developing resistance to treatments and ultimately to end stage metastasis. (The other main driver being genomic instability:
MateoBeach
in
Fight Prostate Cancer
1 year ago
Doctor follow up
Quick recap: in hospital with pneumonia and Pred increased to 10mg (from 4.5mg). Saw GP on discharge and was prescribed 10mg for 4 weeks. He also cancelled my repeat prescription so he said to go back in 4 weeks. So, yesterday I saw another GP to renew my repeat prescription. Immediately I was asked
Quick recap: in hospital with pneumonia and Pred increased to 10mg (from 4.5mg). Saw GP on discharge and was prescribed 10mg for 4 weeks. He also cancelled my repeat prescription so he said to go back in 4 weeks. So, yesterday I saw another GP to renew my repeat prescription. Immediately I was asked
Janann25
in
PMRGCAuk
1 year ago
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What do I do?
I am so sorry this is really long but I am at a loss as to what I should do and struggling waiting. I have struggled with what I believe to be endo for years. I have always suffered with heavy, painful periods and pain in between my periods and I have been back and forth to my GP over the years. They
I am so sorry this is really long but I am at a loss as to what I should do and struggling waiting. I have struggled with what I believe to be endo for years. I have always suffered with heavy, painful periods and pain in between my periods and I have been back and forth to my GP over the years. They
RLS94
in
Endometriosis UK
1 year ago
Thoughts please ...
Hi EveryoneIn no small part due to the advice and knowledge found here, after much to do & tests finally got a 'unofficial' diagnosis of suspected variospastic angina and since April have been taking calcium blockers and statins - all going well until yesterday... Had what I can only describe as a 'turn
Hi EveryoneIn no small part due to the advice and knowledge found here, after much to do & tests finally got a 'unofficial' diagnosis of suspected variospastic angina and since April have been taking calcium blockers and statins - all going well until yesterday... Had what I can only describe as a 'turn
Laurab101
in
British Heart Foundation
1 year ago
Spike in blood sugar levels
I was diagnosed with PBC in 2021. Take my Ursodiol faithfully everyday. Had bloodwork done in April. Everything was good except my ALP is high but below 200. Just had bloodwork done again and now my glucose jumped up and they are now saying I'm pre-diabetic. I have gained weight, is that what is
I was diagnosed with PBC in 2021. Take my Ursodiol faithfully everyday. Had bloodwork done in April. Everything was good except my ALP is high but below 200. Just had bloodwork done again and now my glucose jumped up and they are now saying I'm pre-diabetic. I have gained weight, is that what is
Mcclintock3
in
PBC Foundation
1 year ago
Best Vit K2 +Vit D3?
Hi. I've been reading here about vits K2 +D3, and am keen to try it as I don't want to take Alendronic acid. However, there's so many "makes"! I'm in the UK. I know you can't advertise but what should I be looking out for? Mk7 for vit K is the thing, containing natto I see from some posts, but what is
Hi. I've been reading here about vits K2 +D3, and am keen to try it as I don't want to take Alendronic acid. However, there's so many "makes"! I'm in the UK. I know you can't advertise but what should I be looking out for? Mk7 for vit K is the thing, containing natto I see from some posts, but what is
priss58
in
Bone Health and Osteoporosis UK
1 year ago
Hydroxychloroquine
Hello, Everyone was so helpful last time I posted about being stuck on 3 mg of pred for nearly 5 years and suffering flares when I go lower and the rheumy's desire for me to start methotrexate. With your support I told them I wouldn't continue with the methotrexate. It had a wretched effect on me and
Hello, Everyone was so helpful last time I posted about being stuck on 3 mg of pred for nearly 5 years and suffering flares when I go lower and the rheumy's desire for me to start methotrexate. With your support I told them I wouldn't continue with the methotrexate. It had a wretched effect on me and
JudithWarrior
in
PMRGCAuk
1 year ago
Has 3 years on Prednisolone caused all these problems?
Hi All,I haven't posted for a while but regularly read the daily highlights and continue to learn about our condition and take comfort that there are others who understand the difficulties we face living with PMR. The last few weeks, have been challenging for a few reasons. I'm currently 3 weeks into
Hi All,I haven't posted for a while but regularly read the daily highlights and continue to learn about our condition and take comfort that there are others who understand the difficulties we face living with PMR. The last few weeks, have been challenging for a few reasons. I'm currently 3 weeks into
CarolF1312
in
PMRGCAuk
1 year ago
Cholurso tabs Anyone
please please can someone help I’ve been struggling as in choking on ursonorm capsules 5 a day and I’ve rang the dr this morning she’s changed them to ones called cholurso ursodeoxycholic acid tabs 250mg, I have goitre in my throat which I believe is not helping the problem, I’m due to start these new
please please can someone help I’ve been struggling as in choking on ursonorm capsules 5 a day and I’ve rang the dr this morning she’s changed them to ones called cholurso ursodeoxycholic acid tabs 250mg, I have goitre in my throat which I believe is not helping the problem, I’m due to start these new
Eternity6
in
PBC Foundation
1 year ago
taking tablets
Hi, I am 72 years old, about a year ago had a lumpectomy because of cancer, all ok now. Was given Lectrozole because cancer linked to oestrogen. Had a bone density scan, results were Ostopenia, so given Alendronic Acid and calichew-D3. Is anybody else on these medications? Reading the articles on these
Hi, I am 72 years old, about a year ago had a lumpectomy because of cancer, all ok now. Was given Lectrozole because cancer linked to oestrogen. Had a bone density scan, results were Ostopenia, so given Alendronic Acid and calichew-D3. Is anybody else on these medications? Reading the articles on these
Cheeseand
in
Bone Health and Osteoporosis UK
1 year ago
still no answers
I wrote in a week or so ago about rib pain and protruding left rib cage. Since then I've been to see a private rhematologist, then the practice nurse at my local NH surgery, and lastly took myself to A&E locally on Sunday. The rolling spasm I feel on and off just under the left ribs is the upper
I wrote in a week or so ago about rib pain and protruding left rib cage. Since then I've been to see a private rhematologist, then the practice nurse at my local NH surgery, and lastly took myself to A&E locally on Sunday. The rolling spasm I feel on and off just under the left ribs is the upper
Bennijax
in
PMRGCAuk
1 year ago
Started my grandmother on TTFD
I am my grandmother's primary care taker. I recently learned about HDT and decided to try it on her. Every morning I videotape her eating, which I will use to see if her condition gets better or worse over time. She is 87, having parkinson's for at least 25 years. In the last year her on-state dyskinesia
I am my grandmother's primary care taker. I recently learned about HDT and decided to try it on her. Every morning I videotape her eating, which I will use to see if her condition gets better or worse over time. She is 87, having parkinson's for at least 25 years. In the last year her on-state dyskinesia
philipmurray
in
Cure Parkinson's
1 year ago
Alendronic Acid
I have had 2 doses of alendronic acid and am currently experiencing a first painful, now vision- impairing inflammation in my right eye (steroid drops prescribed).. I see this mentioned as a possible side-effect of AA. Has anyone else experienced this?
I have had 2 doses of alendronic acid and am currently experiencing a first painful, now vision- impairing inflammation in my right eye (steroid drops prescribed).. I see this mentioned as a possible side-effect of AA. Has anyone else experienced this?
FirstSoprano
in
Bone Health and Osteoporosis UK
1 year ago
Stopping Alendronic acid
Currently down to 2mg Pred, after 5 years. Should I stop taking my weekly Alendronic acid?Thanks for your input!
Currently down to 2mg Pred, after 5 years. Should I stop taking my weekly Alendronic acid?Thanks for your input!
BiteyDelano
in
PMRGCAuk
1 year ago
Alendronic Acid and Bloating
I've been taking A Acid now for a month and although things started off well I am now so bloated that I can't stand it! Does The Risedronate stuff have the same effect ? Would I be better off trying that one. Thanks....
I've been taking A Acid now for a month and although things started off well I am now so bloated that I can't stand it! Does The Risedronate stuff have the same effect ? Would I be better off trying that one. Thanks....
superbones
in
Bone Health and Osteoporosis UK
1 year ago
Vitamin Supplements for PMR
I have had PMR since February 2023, diagnosed end of April, started on 15mg Pred, increased to 20mg to get fully on top of pain. Now tapering, down to 17.5mg and plan to go to 15mg at the end of July. Then slowly from there. I have been taking Alendronic Acid tablet one weekly since mid May. I am thinking
I have had PMR since February 2023, diagnosed end of April, started on 15mg Pred, increased to 20mg to get fully on top of pain. Now tapering, down to 17.5mg and plan to go to 15mg at the end of July. Then slowly from there. I have been taking Alendronic Acid tablet one weekly since mid May. I am thinking
Thiago1396
in
PMRGCAuk
1 year ago
Fatigue
Since being diagnosed with an inflammatory disorder three years ago I have suffered with various symptoms most of which are now well controlled and stable. The severe pain in my joints and other parts of my body and the excruciatingly painful headaches thankfully seem to be kept at bay by medication
Since being diagnosed with an inflammatory disorder three years ago I have suffered with various symptoms most of which are now well controlled and stable. The severe pain in my joints and other parts of my body and the excruciatingly painful headaches thankfully seem to be kept at bay by medication
Hightower62
in
NRAS
1 year ago
supplemental pbc treatments
Does anyone have diet and supplement experience and advice to help bring fibroses down? Resist temptation to say you don’t know any other than Ursodoil, obeticholic acid, Fenofibrate and clinical trial Setanix I’m looking for supplemental treatments to practice along with these treatments western
Does anyone have diet and supplement experience and advice to help bring fibroses down? Resist temptation to say you don’t know any other than Ursodoil, obeticholic acid, Fenofibrate and clinical trial Setanix I’m looking for supplemental treatments to practice along with these treatments western
Jlruggie
in
PBC Foundation
1 year ago
IBS and Osteoporosis drugs.
Has anyone had Zoledronic acid infusion for Osteoporosis,and developed IBS symptoms afterwards. I never had it before, and it started a few months after that. I don't get constipation or diarrhoea it's just lots of cramping abdominal pain made worse after I eat.
Has anyone had Zoledronic acid infusion for Osteoporosis,and developed IBS symptoms afterwards. I never had it before, and it started a few months after that. I don't get constipation or diarrhoea it's just lots of cramping abdominal pain made worse after I eat.
jimister
in
IBS Network
1 year ago
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