Experiences with

Axid

Hi there, I was diagnosed with PBC just over two years ago, which was such a shock to me me as I had no idea about this condition (only visited doctor for a routine check-up 😧!!) Have been on Urso ( 2 years) but my ALP and GGT are still high!! Had biopsy and fibroscan 10.1 Specialist says I am

I'm on 8mg steroids, 15mg methotrexate (to get me off the steroids) and Alendronic Acid for OP. My neck and wrists have been in getting worse as I reduce. I wake up with wrists throbbing and am finding it hard to dress myself again. I thought by reducing to 8mg the specialist would be happy but also

I take both. I just ordered more regrettably as I’m now reconsidering the evidence behind both. I know many others on HU take them as well. What is the science to explain why? My reason for taking ALA is a lame one. Dr. David Sinclair does. But as I look in to this more I think that maybe neither

In case anyone takes this medicine and has this specific batch: [i]Class 2 Medicines Recall: Quadrant Pharmaceuticals Ltd, Mefenamic Acid 500mg film coated tablets, EL (22)A/23 Quadrant Pharmaceuticals Ltd are recalling a specific batch of Mefenamic Acid 500mg Film-Coated Tablets as a precautionary

Hi Everyone, I went to my GP back in November thinking I had either an ear or sinus infection, thankfully she was on the ball and after taking something like 10 vials of blood she sent me home with 60mg perisdione to start immediately with a suggested diagnosis of GCA. I think at that point I wasn't

I have recently started treatment for recurring cancer.Rubrac a didn't work for me and I have already had Carbo/Taxol and Carbo/Caelyx. As my son and his family are visiting from New Zealand in July (prompted by my increasing ill health) I decided to try Anastrazole tablets rather than weekly Taxol,

Hi all, in 2019 whilst lifting my suitcase at the airport I had a horrendous pain in my lower back. Fast forward a few months finally got a x-ray which showed a compression fracture of L2. Finally got a dexa scan in April 2021 and confirmed osteoporosis of the spine with a T score of -3.9. My doctor

Hi all, I’ve just been diagnosed with osteoporosis and I’m 29. This came about as I realised my toe was broken but didn’t have a clue how it happened so went to A&E. They x rayed it said it was fractured and also said my foot density looked on the lower side and to follow up with the GP. I did that and

After a recent DEXA scan I have found that I have osteopenia of the hips and some osteoporosis at L3 and L4. My doctor has put me on Alendronic acid tablets and 1200 mg calcium supplements(Adcal D3). After the first six days I had constipation and consequent haemorrhoids. I took the alendronic acid and

Here is the update after consultant visit. As PMR pro suspected I have now been put on Alendronic acid, a liquid bottle of 70mg made up with 30mg water to 100mg weekly due to recent DEXA scan. She did say she didn't think my scan was bad as I am just past menopaused and many women are at this point without

Good morning, everyone! I wonder if anyone else has had problems following a denosumab (Prolia) injection. I was first diagnosed with PMR in 2015, and at that point, was told to discontinue the alendronic acid that I had been on for many years because it had been discovered it was not the “wonder drug

Good day, we had a consult with our urologist and he is prescribing zoldron for my dad because of metastasis, i have read some terrible side effects so i told our uro about that, to which he replied it probbly depends on the brand as some may have bad additives, also none of his patients reported any

Hello all, just a quick query . I've been on pred since the beginning of March , currently 12.5mg. I'm on Alendronic Acid too. I have been on Letrozole since my Mastectomy in June 2019. I had a bone scan then which is standard when starting something like Letrozole as it increases osteoporosis risk.

In 2014, after taking alendonate for (?) 5+ years, my left femur broke as I walked down a very slight slope. I have a intramedullary pin running from hip to knee. In 2020, on March 3, after not taking AA for nearly 6 years, I stood up to get off the bus, and my right femur broke, same reason. Now

Hi guys finally getting some answers of what has been going on with my bladder. (Bleeding from it) Had a cystoscopy yesterday, after the usual embarrassing bits, I found it quite fascinating to see inside my bladder on the screen. She never gave me a diagnosis but looking at my past history it is probably

Bile acids (BAs) belong to cholesterol-derived sterols. Due to the side chain carboxyl group and hydroxylation of their steroid ring they are more polar than cholesterol. They have an amphipatic character for which they are known as natural detergents. Majority of cholesterol is excreted by bile acids

After six years continuously on lupron, I had scan done on April 1st. I was DX with osteopenia. Doctor wants me too take alendronate 70mg once a week, I have some concerns about the side effects. Anyone taking this drug and what was your side effects. Thank ET51

Help. Don’t know who to contact if anyone. Could be I’m a Jessie! On Wednesday of last week my left foot started swelling (I have Lupus, Sjogrens and fibromyalgia with costochondritis). Then the next day the other foot was a bit puffy. On that day I travelled from Wales to Bedfordshire and then from

Here is one out of far left field https://www.frontiersin.org/articles/10.3389/fphar.2021.692574/full PROTAC: An Effective Targeted Protein Degradation Strategy for Cancer Therapy www.frontiersin.orgSi-Min Qi1†, www.frontiersin.orgJinyun Dong2†, www.frontiersin.orgZhi-Yuan Xu2, www.frontiersin.orgXiang-Dong

High mobility group box 1 (HMGB1) is upregulated in nearly every tumor type. Importantly, clinical evidence also proposed that HMGB1 is particularly increased in metastatic prostate cancer patients. Besides, a growing number of studies highlighted that HMGB1 could be a successful therapeutic target for