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Clinical impact of mutated JAK2 allele burden reduction in polycythemia vera and essential thrombocythemia
»The variant allele frequency (VAF) of driver mutations (JAK2, CALR) in myeloproliferative neoplasms is associated with features of advanced disease and complications. Ruxolitinib and interferon were reported to variably reduce the mutant VAF, but the long-term impact of molecular responses (MR) remains
»The variant allele frequency (VAF) of driver mutations (JAK2, CALR) in myeloproliferative neoplasms is associated with features of advanced disease and complications. Ruxolitinib and interferon were reported to variably reduce the mutant VAF, but the long-term impact of molecular responses (MR) remains
Manouche
in
MPN Voice
18 days ago
Terbium-161 - As a follow-up to Alicia Morgan's comments in the PeterMac GUcast interview posted earlier by marnie46.
I meant to include this article, a 24 Nov 2023 news release on Terbium-161, in a followup reply to Marnie's post of the Dr. Morgan interview by the excellent PeterMac team several days back. [i]
Three big challenges in metastatic prostate cancer | Dr Alicia Morgans
[/i] [i]
https://healthunlocked.com
I meant to include this article, a 24 Nov 2023 news release on Terbium-161, in a followup reply to Marnie's post of the Dr. Morgan interview by the excellent PeterMac team several days back. [i]
Three big challenges in metastatic prostate cancer | Dr Alicia Morgans
[/i] [i]
https://healthunlocked.com
cujoe
in
Fight Prostate Cancer
19 days ago
Important from The PBC Foundation....
We are asking for your help. 4/6/2024 Very directly. Very succinctly. We need your help. This is the most important thing the Foundation has ever worked on: more important than the surveys, more important than the helpline, more important than the name change. We are writing a letter which we
We are asking for your help. 4/6/2024 Very directly. Very succinctly. We need your help. This is the most important thing the Foundation has ever worked on: more important than the surveys, more important than the helpline, more important than the name change. We are writing a letter which we
DonnaBoll
Administrator
in
PBC Foundation
19 days ago
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Genetic background strongly influences the impact of carrying the Thr92Ala-DIO2 polymorphism in the male mouse
Are you male? Are you a mouse? Do you carry the Thr92Ala-DIO2 allele? Can you wait for the publication of this paper? Can you wait for the human version of this trial? And do you consider it necessary to wait for the eventual publication of the human trial before considering T3? It is undoubtedly
Are you male? Are you a mouse? Do you carry the Thr92Ala-DIO2 allele? Can you wait for the publication of this paper? Can you wait for the human version of this trial? And do you consider it necessary to wait for the eventual publication of the human trial before considering T3? It is undoubtedly
helvella
Thyroid UK
in
Thyroid UK
20 days ago
Annovis Bio Inc. (NYSE: ANVS) Schedules Investor Webcast
For those of you who might be interested... MALVERN, Pa. June 5, 2024 -- Annovis Bio Inc. (NYSE: ANVS) (“Annovis” or the “Company”), a late-stage clinical drug platform company pioneering transformative therapies for neurodegenerative disorders such as Alzheimer’s Disease (AD) and Parkinson’s Disease
For those of you who might be interested... MALVERN, Pa. June 5, 2024 -- Annovis Bio Inc. (NYSE: ANVS) (“Annovis” or the “Company”), a late-stage clinical drug platform company pioneering transformative therapies for neurodegenerative disorders such as Alzheimer’s Disease (AD) and Parkinson’s Disease
Canddy
in
Cure Parkinson's
20 days ago
Phase 1/2 ARV-766 clinical trial
“The purpose of this study is to assess the safety and tolerability (good and bad effects) and how prostate cancer responds to two different doses of the investigational study drug (ARV-766) in combination with Abiraterone in men with metastatic cRPC who have not received prior novel hormonal therapies
“The purpose of this study is to assess the safety and tolerability (good and bad effects) and how prostate cancer responds to two different doses of the investigational study drug (ARV-766) in combination with Abiraterone in men with metastatic cRPC who have not received prior novel hormonal therapies
Woodman33
in
Advanced Prostate Cancer
21 days ago
FDA Greenlights Phase 2/3 Trial of KPG-121/Abiraterone in mCRPC
A clinical trial to evaluate the combination of a new drug called KPG-121 with abiraterone acetate (Zytiga) for treating metastatic castration-resistant prostate cancer (mCRPC) as a first-line therapy has been approved by the FDA. KPG-121 is an investigational drug that targets specific proteins involved
A clinical trial to evaluate the combination of a new drug called KPG-121 with abiraterone acetate (Zytiga) for treating metastatic castration-resistant prostate cancer (mCRPC) as a first-line therapy has been approved by the FDA. KPG-121 is an investigational drug that targets specific proteins involved
God_Loves_Me
in
Advanced Prostate Cancer
21 days ago
Denmeade on identifying patients who may benefit from BAT
Dr. Denmeade concluded his presentation with the following key takeaways: The presence of AR alterations in ctDNA may identify patients who may or may not benefit from BAT In this study patients with no AR alterations treated with BAT exhibit significantly shorter PFS and OS compared to those treated
Dr. Denmeade concluded his presentation with the following key takeaways: The presence of AR alterations in ctDNA may identify patients who may or may not benefit from BAT In this study patients with no AR alterations treated with BAT exhibit significantly shorter PFS and OS compared to those treated
cigafred
in
Fight Prostate Cancer
21 days ago
low T4 and T3 normal TSH
I posted earlier in the year about my daughter diagnosed with post partum thyroiditis , no treatment at the time but endocrinologist said he’d keep an eye on her! Her most recent results seem odd to me in that both T4 and T3 are very low but her TSH is also low - her case has been closed and results
I posted earlier in the year about my daughter diagnosed with post partum thyroiditis , no treatment at the time but endocrinologist said he’d keep an eye on her! Her most recent results seem odd to me in that both T4 and T3 are very low but her TSH is also low - her case has been closed and results
Sususulio
in
Thyroid UK
9 months ago
post ablation update
He did said that this can happen but he now thinks I have
atrial
flutter
so depending on what the heart monitor picks up I am now looking at having another ablation which will be decided when I see him in March.Has this happened to any of you that you have gone from paroxysmal to
atrial
flutter
?
He did said that this can happen but he now thinks I have
atrial
flutter
so depending on what the heart monitor picks up I am now looking at having another ablation which will be decided when I see him in March.Has this happened to any of you that you have gone from paroxysmal to
atrial
flutter
?
Bell50
in
AF Association
1 year ago
Totally confused
I had a partial thyroidectomy about 2010. My thyroid levels were fine for several years but then started dropping into hypothyroidism range. I was put on Levothyroxine at 50mg and was ok for few years. Tested Jan 2023 was ok. Tested early Feb 2024 and was hyper not hypo so my gp reduced the levothyroxine
I had a partial thyroidectomy about 2010. My thyroid levels were fine for several years but then started dropping into hypothyroidism range. I was put on Levothyroxine at 50mg and was ok for few years. Tested Jan 2023 was ok. Tested early Feb 2024 and was hyper not hypo so my gp reduced the levothyroxine
Battlecat
in
Thyroid UK
25 days ago
Long Covid three years on, and what Covid 19 has planned for Q3-4/ 24
This long and informative article https://erictopol.substack.com/p/long-covid-at-3-years co-presented by Eric Topol and Ziyad Al-Aly, majors on two new studies on health outcomes for large numbers of early COVID-19 patients who were followed up for three years. The VA study in > 135,000 people showed
This long and informative article https://erictopol.substack.com/p/long-covid-at-3-years co-presented by Eric Topol and Ziyad Al-Aly, majors on two new studies on health outcomes for large numbers of early COVID-19 patients who were followed up for three years. The VA study in > 135,000 people showed
bennevisplace
in
CLL Support
26 days ago
FDA clearance for SYNC-T SV-102, a pioneering combo immunotherapy for Metastatic Castrate-Resistant Prostate Cancer
Source link: https://finance.yahoo.com/news/syncromune-inc-announces-fda-clearance-232200345.html SYNC-T SV-102 Therapy combines partial tumor oncolysis with a fixed-dose combination multi-target biologic drug to provide a novel, personalized therapeutic approach for the treatment of metastatic
Source link: https://finance.yahoo.com/news/syncromune-inc-announces-fda-clearance-232200345.html SYNC-T SV-102 Therapy combines partial tumor oncolysis with a fixed-dose combination multi-target biologic drug to provide a novel, personalized therapeutic approach for the treatment of metastatic
God_Loves_Me
in
Advanced Prostate Cancer
26 days ago
Piperine and L-dopa producing probiotic
I recently ran across a couple of things about gut bacteria that I thought were interesting. The first involves the use of piperine (an extract of black pepper) to keep l-dopa from being converted to dopamine by bacteria in the small intestine, leaving more to travel to the brain; https://onlinelibrary.wiley.com
I recently ran across a couple of things about gut bacteria that I thought were interesting. The first involves the use of piperine (an extract of black pepper) to keep l-dopa from being converted to dopamine by bacteria in the small intestine, leaving more to travel to the brain; https://onlinelibrary.wiley.com
Rufous2
in
Cure Parkinson's
26 days ago
pleural effusion
hi all you very supportive ladies . 4 years since my diagnosis with stage 3 ovarian cancer I have had all the chemo combinations available plus Avastin and PARP inhibitors . I was then in a clinical trial for a year which had a small effect and finished in March. a couple of weeks ago , I was admitted
hi all you very supportive ladies . 4 years since my diagnosis with stage 3 ovarian cancer I have had all the chemo combinations available plus Avastin and PARP inhibitors . I was then in a clinical trial for a year which had a small effect and finished in March. a couple of weeks ago , I was admitted
Lookingahead
in
My Ovacome
27 days ago
Aspen Neuroscience to Present at International Society for Cell & Gene Therapy (ISCT) Annual Meeting
As part of the ISCT 2024 Translational Pathway Sessions, as well as the ISCT main program, Aspen's Chief Scientific Officer Xiaokui Zhang, Ph.D., and Chief Technology Officer Kim Raineri will discuss developments in autologous research and development, including for ANPD001, Aspen's autologous iPSC-derived
As part of the ISCT 2024 Translational Pathway Sessions, as well as the ISCT main program, Aspen's Chief Scientific Officer Xiaokui Zhang, Ph.D., and Chief Technology Officer Kim Raineri will discuss developments in autologous research and development, including for ANPD001, Aspen's autologous iPSC-derived
Farooqji
in
Cure Parkinson's
27 days ago
PROTACS: what they are and the good and bad of these molecules
Fascinating, and they are currently being tested also for degenerative diseases...they are a rather new technique...and yet we already have "advanced PROTACs", the speed of research is impressive... 1. PROTAC Mechanism Proteolysis-targeting chimeras (PROTACs) have emerged as a promising therapeutic
Fascinating, and they are currently being tested also for degenerative diseases...they are a rather new technique...and yet we already have "advanced PROTACs", the speed of research is impressive... 1. PROTAC Mechanism Proteolysis-targeting chimeras (PROTACs) have emerged as a promising therapeutic
Maxone73
in
Advanced Prostate Cancer
27 days ago
News from Malecare and OpenAI
Today, GPTs in the Store are now available to all ChatGPT users, allowing more than 100 million weekly active users to experience Cancer Copilot, Clinical Trial Navigator and the others in the store for free. Also, GPTs now use the newest flagship model, GPT-4o. Here are direct links: https://chatgpt.com
Today, GPTs in the Store are now available to all ChatGPT users, allowing more than 100 million weekly active users to experience Cancer Copilot, Clinical Trial Navigator and the others in the store for free. Also, GPTs now use the newest flagship model, GPT-4o. Here are direct links: https://chatgpt.com
Darryl
Partner
in
Prostate Cancer Network
28 days ago
news from Malecare and OpenAI
Today, GPTs in the Store are now available to all ChatGPT users, allowing more than 100 million weekly active users to experience Cancer Copilot, Clinical Trial Navigator and the others in the store for free. Also, GPTs now use the newest flagship model, GPT-4o. Here are direct links: https://chatgpt.com
Today, GPTs in the Store are now available to all ChatGPT users, allowing more than 100 million weekly active users to experience Cancer Copilot, Clinical Trial Navigator and the others in the store for free. Also, GPTs now use the newest flagship model, GPT-4o. Here are direct links: https://chatgpt.com
Darryl
Partner
in
Advanced Prostate Cancer
28 days ago
Wednesday's Word
[u][i]
Second line therapy
[/i][/u] [u][i][/i][/u]
This a term used In PBC a patient does not respond to Urso - usually within a year's time from the start of dosing. A different drug of choice is needed.
The only approved second line treatment is the use of Ovaliva (obeticholic acid
[u][i]
Second line therapy
[/i][/u] [u][i][/i][/u]
This a term used In PBC a patient does not respond to Urso - usually within a year's time from the start of dosing. A different drug of choice is needed.
The only approved second line treatment is the use of Ovaliva (obeticholic acid
DonnaBoll
Administrator
in
PBC Foundation
28 days ago
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