Just wondered how many of us are considered non-responders and are in the slightly over upper end of normal to around the 200 range of Alkaline Phosphatase who have stayed on Ursodiol only. How long have you been in this range? Have your symptoms advanced?
I am also AMA-negative. I was diagnosed last year in March via biopsy. My ALP went from above 400 to about 238 in the first few months on Ursodiol. In May this year it was around 180 then it went to 186. My blood test this week has it at 197. I am on 1000 Ursodiol. My hepatologist mentioned Ocaliva. I am not scheduled to see him until next year.
Of course having normal LFT s doesn’t mean that you won’t progress but it’s supposed to mean you have better chance of not progressing.
Also If you went obeticholic acid are you glad you did?