Often I have low wbc and require Granix to pick them up with the help of my hematologist. I take Ursodiol which does help with PBC. For the itching my doc recommends I take Cymbalta with Urso and Cholestyramine powder together and it works pretty well. The powder u need to take it 1 hour before meds or 4 hours after meds. I am currently on the liver transplant list. Meanwhile for acsities I have had 10 paracentesis and 12 thoracentesis. I am in the process of getting a TIPS procedure to decrease sticking me for thora and paracentesis. I developed portal hypertension. Have had 1 amputation to index finger for Raynauds, very dry mouth which has caused tooth infections. Have tight skin because of Scleroderma and hard time swallowing causing esophageal varices. Constant hospital admissions for infections for low wbcs. Peripheral neuropathy and sleeping rest syndrome giving me trouble sleeping with cramping. Its been a rough ride. Hoping after transplant some things will dimish.