I have spent the last year almost, in a daily fight with deep depression and anxiety brought on by pre menopause. I am on a raft of meds including HRT. I have been put on a low dose of Premique modified release tablets but I do not feel much improvement. I am on a period at the moment and had another one about 6 weeks ago. I have thoughts of doing something to myself as I want it all to stop. I am fearful most of the time and am finding it very difficult to cope with the feelings I feel. Everyday day is an up hill struggle. Please can someone help as I feel am loosing it completely.