I have treatment-resistant depression. The problem is that I have tried just about everything to help it and very little makes a difference. I’ve made a list of the things I can remember trying (none of which significantly helped):
Paroxetine (vomiting, shaking, blood rush)
Forgot the name (so drowsy couldn’t get up)
Forgot the name (made me feel like shit)
Lurasidone (tolerable nausea)
Lithium (could try longer)
I am currently doing DBT with a psychotherapist, and am starting back on different antidepressants (Wellbutrin) so I can do a clinical trial with an anti-inflammatory (because there is a correlation between depression and inflammation in the brain). But honestly, I don’t have much hope for any sort of antidepressants after trying so many, and the trial is so close to the beginning still that the results aren’t very hopeful.
So what did make a difference to my depression? One thing. A family vacation to Cuba last February. I was extremely depressed a year ago (about the point I’m at currently) when we went on a family trip. I adore the tropics. I love the sun and the beach and the water. We were there for one week. And after we came home, my mood rose from an average of 2 or 3/10 to 5/10. It stayed that way for about three months. And then it started dropping again until I was back where I was before. I have been depressed for several years, but that was the only time anything has made a significant change in my depression.
So what I’m looking for are the weird things. The things you found helped when nothing else was working. Or anything that you can recognize, looking back, as something that triggered a good period in your depression. Or just anything that helped you which I have not tried. Thank you