Docetaxel treatment failure, running out of options.

[MarylandGuy]

Diagnosed in early 2023 with a PSA of around 200. Was in bad enough shape where I needed a transfusion and a hospital stay. Started on Lupron, Nubeqa and Zometa. That worked very well and over six months brought PSA under 1 and felt pretty good. Then in January 2024 that started to fail and PSA started rising. Did three treatments of Provenge and started on Lynparza/abiraterone which slowed progression for a few months into mid 2024. Then switched to Talzanna and xtandi which only slowed progression a bit. At this time my PSA is around 6 and it is November 2024.

My recent PSMA pet scans show six bone mets and almost no cancer in prostate. This cancer is now basically entirely in my bones and in no other soft tissue.

We then started chemotherapy with docetaxel (and prednisone) and PSA stayed the same then slowly rises till January PSA 17. Now in February my PSA came back at 34.

I am BRCA2 positive and therefore that is why we tried the PARP inhibitors.

So I have never done radiation. I have been told I have too many spots for traditional radiation but my doctor is now talking about Pluvicto or Xofigo next. What other options?

[Tall_Allen]

I'm a fan of Xofigo combined with other therapies. Perhaps discuss these with your oncologist:

prostatecancer.news/2021/02...