Experiences with

Pluvicto

Dr refer me for Pluvicto and Dr nuclear medicine told me I do not have enough PSMA for pluvicto from my previous PSMA PET SCAN now they are ordering FDG scan to if pluvicto is good options or not.

Can anyone share how long Pluvicto continues to slow the growth of cancer cells in Metastatic disease? Also, can Pluvicto be repeated?

does not seem to matter very much with Pluvicto as long as there is sufficient PSMA avidity.

I’ve found a few references promoting, and even a trial or two regarding, the use of Pluvicto again after positive response. Do any of you have any additional info?

Pluvicto did not impair the ability of patients to be treated with subsequent chemotherapy.

I am being prepped for Pluvicto( Lu177) but have been neglected for urinary incontinence. I won't talk to my doctor until 2 days before starting therapy. Does anyone have a similar experience. Also. My hemoglobin is only 11.2. Is that enough for Pluvicto?

I have read about this being a possibility with the pluvicto. He did have a PSMA scan prior to treatment which showed PSMA-avid tumors. What do we do at this point?

We have the option to either start Pluvicto/Lutetium or Chemotherapy. We are leaning towards Pluvicto/ Lutetium as it seems to be more targeted treatment and has lower side effects.

His MO is leaning toward Pluvicto as next option since he already had chemo. But husband is concerned about the radiation and the need to self isolate from Pluvicto. We have 4 young grandchildren and my daughter is pregnant.

Hi, I’m seeking anyone with personal experience or knowledge of someone else undergoing Pluvicto while on dialysis. We are running into many roadblocks getting my dad Pluvicto, because the dialysis center wants his first dialysis after each Pluvicto infusion to be done somewhere else.

Questions struggling with (1) Does starting with Pluvicto reduce expected longevity - body becomes immune eventually to every treatment and would chemo then pluvicto increase longevity (2) in people’s experience, can you do chemo after Pluvicto or is bone marrow issues a given side effect.

FIL has exhausted other options and did well on Pluvicto this year. PSAs started going up slow and steady after his sixth treatment of Pluvicto (still lower than where he started). Has anyone gotten approval for a second round of Pluvicto for six more treatments?

FC705, a new radioligand therapy for metastatic castration-resistant prostate cancer (mCRPC), outperformed Pluvicto in phase 2 trials, achieving a 60.0% tumor response rate compared to Pluvicto’s 29.8% (and it works on both lymphnode and bone metastases, Pluvicto works only on lymphnode mets).

As the title says, my father will be discontinuing Pluvicto after 2 rounds as his latest PSMA PET showed some slight decrease in areas but ultimately new growth / metastasis to different areas in the bone.

My siblings and I wonder whether someone in his situation who should do Pluvicto.

Dad failed Zytiga, Docetaxel, Pluvicto, Cabazitaxel. He has extensive bone metastases. What’s left? Any other options?

His MO wants to start him on pluvicto at this time instead of doing spot radiation treatment. Does this progression mean he has now failed xtandi/talzenna combo? After pluvicto what options are left? Thanks to this platform and all for input/support.

He talked about Pluvicto and how it works, he made the statement that a chemo drug can be used instead of Lu 177. Has anyone heard of this. ET

He also received an IV dose of solu-medrol this week and has been taking ibuprofen as well for potential inflammation from pluvicto. Just curious about any other input for what others have done for management of pain in spine mets? Thanks.

I know the Pluvicto dosage may need to be changed or the infusions may need to end . I am wonder what kind of lab numbers they would be looking at.