I received radiation treatment to my pelvic area this past spring for castrate-resistant lesions in my prostate and two lymph nodes. A month after completing radiation, my PSA dropped from .22 to .09, but a CT scan showed only a small decrease in size of the lesions. Six weeks later, my PSA increased slightly to .11. Because my cancer spreads without emitting much PSA, my oncologist has ordered a PSMA scan and suspects the radiation was not effective. Has anyone had a similar issue? Are there any recommendations on treatment options? Thanks.
Treatment options for local PC that i... - Advanced Prostate...
Treatment options for local PC that is resistant to radiation
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Eddy-Merckx
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Can you describe the cryoablation performed on your liver. I'm aware of liver spheres radiation used for treating liver cancer, and surgery but I wasn't aware of freezing cancer on the liver. What type of doctor performed it?
What sensation did you feel?
How was recovery?
I do not recall the type of doctor that performed the cryoablation but I think he was from intervention radiology at Dana-Farber. I was under anesthesia the entire procedure and there was very little discomfort afterward. I had a 2 week recovery period where I was not allowed to perform intense exercise but could go about my regular activities. It is not part of standard care, but I was willing to take the risk given my age and that I have young children.
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I suggest you discuss a biopsy of a recent large met followed by histology, IHC and genomics. The IHC should include as many of these as possible: AR (androgen receptor), PSA, PSMA, MSH2, MSH6, STEAP1, PD-L1, chromogranin A (CGA), neuron-specific enolase (NSE), synaptophysin (SYP), DLL-3, CD56, Somatostatin (SST).In your case, an FDG PET scan may show more than a PSMA PET.
Thanks! Much appreciated.
TA, can you explain what an IHC is?
I don't recollect ever hearing of that diagnostic tool.
Immunohistochemistry:
cancer.gov/publications/dic...
Is this something recent, or recently evolving for use with prostate cancer?
I've never heard of it before?
I'm familiar with it in the context of dealing with my oral pathology buddies (there is some difference of opinion wrt its diagnostic usefulness for certain oral lesions). I am not familiar with its use in prostate cancer.
Not recent
TA, Do you have anything about prostate cancer related IHC on your prostate cancer site?
i don't recall. I don't usually write about diagnostic tests unless they are new.