Next step on my 20 journey with the Beast is Xofigo. The Docetaxel, 5 sessions, started in February, 2021, and finished in May, 2021, and PSA stayed below 1 until January, but now it is climbing again - 9.1. I am still on Eligard and also started 50 MG of Cassodex to see if the progression could be slowed down. Seems to be working a little because my PSA only climbed from 8.3 to 9.1 in February.
Yesterday, we met with the Radiation Oncologist at Mayo Phoenix and he recommended 6 cycles of Xofigo. My question is - have any of you tried Xofigo after Docetaxel and did you have any luck with it. I am feeling the best I have felt in a year after the chemo.
When areas of uptake of Thallium 99 were found in two areas and a steadily increasing PSA, my MO discontinued Xtandi and started me on radium 233. I remain on quarterly injections of Eligard.
My start has Beren pushed out a week. We can compare notes in two weeks. Good luck today. From my research, I found this to be a good radioopharmacuetical.
I ended my Xofigo treatment in September, 2020. My research doctor recommended it for a met in my hip. Since I already had radiation to that area I could not do radiation there again. The met shrank and the pain went away. Still working today.
I was chemo naive when I was prescribed Xofigo and I completed all six (1 per month) treatments. It was a very positive experience for me, and I marveled at the science behind Radium 223. Unfortunately, I was the only one of my cohort to make it all the way. The other men taking treatment had all been through chemo before. I'm probably not saying this right but their white blood cell counts dipped dangerously low so that giving them another dose of Xofigo would have killed them. Please talk to the radiological oncologist from your Nuclear Medicine department about potential side effects.
Radium 223 did not eliminate my metastases, but that was never the objective. I had accumulated a large amount of cancer in a few areas. Cancer Treatment Centers of America suggested that this treatment might debulk the tumor, decreasing the size of the tumor. As a matter of fact, CTCA warned me that my PSA would rise during the (hopefully) six months I would receive Radium 223, but not to worry as the resumption of Androgen Deprivation Therapy would bring my PSA back down to a manageable number. I was pleased to find that the cancer behaved exactly as CTCA stated it would after I had finished the full course of Radium 223. Best of luck to you, Tom. I hope all goes as successfully for you as it did for me!
After Ra223 I was given treatment with Abiraterone acetate and prednisone for a few years. The pandemic caused me to be asked by CTCA to seek oncology services from a local source. My new oncologist had been assuming that my cancer was being held at bay by the ADT, but that proved not to be the case. My cancer can spread without my PSA increasing much. I recently had metastatic prostate cancer found in the lesions removed from my bladder. A recent PSMA scan found a couple of pelvic lymph nodes which expressed Prostate Specific Membrane Antigen. I'm waiting on next generation gene sequencing to tell me which medicine they will try next. My body aches and I have hip pain. I take Oxycontin for regular pain and have Percoset to use for breakthrough pain. Best of luck on Monday!
I started 223 yesterday. The Radiologist said to expect increased pain from tumor death. 2nd day and last night increased pain. Have many Mets in spine and throughout body. Will keep you posted as treatment progresses.
Oh Goldberg - please do. I start my treatments next Monday. How are you feeling today. What was your latest PSA. Mine is 9.1. Your are going to get you shot once a month - correct? Everyone says watch you blood counts. Thanks so much. Let's compare note through the process.Tom
Couple of days pain increased. For the next three/4days diminished to the usual uncomfortable. Part of that is due to a bad disc in my lower back. Calling for shots to that area as it’s not cancer.
Hi Goldberg:Checking in to see how you are feeling a week or so after your 223 injection.
I get my first one tomorrow.
Thanks,
Tom
• in reply to
Hi Goldberg:
How are you feeling? I hd my first injection 2 weeks ago. Overall, versus chemo, feeling great . Some pelvic bone pain but I don't know if that is 223 or old age. What about you.
He had 10 sessions where his PSA got down to 1.2. Got a couple of months off until it climbed back up to 48. This second time of docetaxel his PSA didn't get below 24 and has been slowly climbing every session. He just completed his 11th cycle this 2nd time (21 total) where it went from 42 to 49. He's been tolerating it pretty well considering he's had so much of it. Our next appointment in 2 weeks we'll discuss the next step - which his doc has already mentioned would be Xofigo. He has bone mets and no organ involvement. I'm not sure how much of a break he'll get between the chemo and starting Xofigo, but I guess we'll find out at our next visit. We're still holding out hope to get LU177. His doc is checking into this also.
His PSA at dx was 3300. Initially he had abiraterone and then Xtandi. Both failed after a few months. He's had 2 Foundation One studies. The 2nd one just weeks ago. The results show nothing actionable.
You hang in there also! Hoping you tolerate it well and it helps keep this monster at bay. Keep us posted!
Thanks Yadifan. His story is much worse than mine. I quit chemo after 5 sessions because of foot neuropathy. My psa was down to 0,4. Stayed there for 6 months and now 10 again. I too only have bone mets. First injection of 223 yesterday. So far so good. No side effects yet. Hope it works. Please keep me posted. Thanks for your input.Tom
Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.
Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.
Diagnosis + 18 years; update since Xofigo
Xofigo is up next
Anyone w Xofigo experience?
Info on Xofigo
