Starting Xofigo RA 223: Good morning... - Advanced Prostate...

Advanced Prostate Cancer

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Starting Xofigo RA 223

tceinvestments profile image
31 Replies

Good morning Warriors:

Next step on my 20 journey with the Beast is Xofigo. The Docetaxel, 5 sessions, started in February, 2021, and finished in May, 2021, and PSA stayed below 1 until January, but now it is climbing again - 9.1. I am still on Eligard and also started 50 MG of Cassodex to see if the progression could be slowed down. Seems to be working a little because my PSA only climbed from 8.3 to 9.1 in February.

Yesterday, we met with the Radiation Oncologist at Mayo Phoenix and he recommended 6 cycles of Xofigo. My question is - have any of you tried Xofigo after Docetaxel and did you have any luck with it. I am feeling the best I have felt in a year after the chemo.

We sure always appreciate all of your input.

Thanks - Tom

31 Replies
CAMPSOUPS profile image
CAMPSOUPS

Well smarter heads will join in here and they would probably ask what is on my mind.When were your most recent scans and what was revealed from them?

I thought RA-223 was most often used in cases of extensive bone mets but maybe I am wrong.

A radiologist is recommending the radiological RA-223 for you. What does your MO have to say?

tceinvestments profile image
tceinvestments in reply to CAMPSOUPS

I do have bone minutes that are now active again no cancer in the soft tissues thankfully

Tall_Allen profile image
Tall_Allen

Good call! Consider combining Xofigo with Xtandi and Provenge. You can read about combinations here:

prostatecancer.news/2021/02...

tceinvestments profile image
tceinvestments in reply to Tall_Allen

Thanks taMy MO wants me to do just zofigo. I trust your recommendation and I hope it works.

Thanks so much for the input

Tom

Clotter1 profile image
Clotter1 in reply to tceinvestments

When areas of uptake of Thallium 99 were found in two areas and a steadily increasing PSA, my MO discontinued Xtandi and started me on radium 233. I remain on quarterly injections of Eligard.

tceinvestments profile image
tceinvestments in reply to Clotter1

i start 223 today.How are you feeling????

Clotter1 profile image
Clotter1 in reply to tceinvestments

My start has Beren pushed out a week. We can compare notes in two weeks. Good luck today. From my research, I found this to be a good radioopharmacuetical.

tceinvestments profile image
tceinvestments in reply to Clotter1

Thanks Clotter - I will keep you posted, and you please do the same. Good luck to you..

tceinvestments profile image
tceinvestments in reply to tceinvestments

Injection yesterday - so far so good.

Magnus1964 profile image
Magnus1964

I was on xofigo and it worked on my bone mets. Not complaints on side effects either.

tceinvestments profile image
tceinvestments in reply to Magnus1964

Thanks Magnus:Your input is always so appreciated.

Did the mets shrink and PSA go down?

How long did the positive effects of Xofigo last?

Did you have any side effects???

Thanks,

Tom

Magnus1964 profile image
Magnus1964 in reply to tceinvestments

I ended my Xofigo treatment in September, 2020. My research doctor recommended it for a met in my hip. Since I already had radiation to that area I could not do radiation there again. The met shrank and the pain went away. Still working today.

tceinvestments profile image
tceinvestments in reply to Magnus1964

Oh that's great news I'm hoping for the same result.Have a great day

Scoofer33 profile image
Scoofer33

I was chemo naive when I was prescribed Xofigo and I completed all six (1 per month) treatments. It was a very positive experience for me, and I marveled at the science behind Radium 223. Unfortunately, I was the only one of my cohort to make it all the way. The other men taking treatment had all been through chemo before. I'm probably not saying this right but their white blood cell counts dipped dangerously low so that giving them another dose of Xofigo would have killed them. Please talk to the radiological oncologist from your Nuclear Medicine department about potential side effects.

tceinvestments profile image
tceinvestments in reply to Scoofer33

Will do - thanks for your input Scooter.Did it eliminate your mets?????

Thanks Tom

Scoofer33 profile image
Scoofer33 in reply to tceinvestments

Radium 223 did not eliminate my metastases, but that was never the objective. I had accumulated a large amount of cancer in a few areas. Cancer Treatment Centers of America suggested that this treatment might debulk the tumor, decreasing the size of the tumor. As a matter of fact, CTCA warned me that my PSA would rise during the (hopefully) six months I would receive Radium 223, but not to worry as the resumption of Androgen Deprivation Therapy would bring my PSA back down to a manageable number. I was pleased to find that the cancer behaved exactly as CTCA stated it would after I had finished the full course of Radium 223. Best of luck to you, Tom. I hope all goes as successfully for you as it did for me!

tceinvestments profile image
tceinvestments in reply to Scoofer33

Thanks so much Scooter. How are you doing now????

Scoofer33 profile image
Scoofer33 in reply to tceinvestments

After Ra223 I was given treatment with Abiraterone acetate and prednisone for a few years. The pandemic caused me to be asked by CTCA to seek oncology services from a local source. My new oncologist had been assuming that my cancer was being held at bay by the ADT, but that proved not to be the case. My cancer can spread without my PSA increasing much. I recently had metastatic prostate cancer found in the lesions removed from my bladder. A recent PSMA scan found a couple of pelvic lymph nodes which expressed Prostate Specific Membrane Antigen. I'm waiting on next generation gene sequencing to tell me which medicine they will try next. My body aches and I have hip pain. I take Oxycontin for regular pain and have Percoset to use for breakthrough pain. Best of luck on Monday!

tceinvestments profile image
tceinvestments in reply to Scoofer33

Thanks so much Scooter.Appreciate your input.....

Goldberg profile image
Goldberg

I started 223 yesterday. The Radiologist said to expect increased pain from tumor death. 2nd day and last night increased pain. Have many Mets in spine and throughout body. Will keep you posted as treatment progresses.

tceinvestments profile image
tceinvestments in reply to Goldberg

Oh Goldberg - please do. I start my treatments next Monday. How are you feeling today. What was your latest PSA. Mine is 9.1. Your are going to get you shot once a month - correct? Everyone says watch you blood counts. Thanks so much. Let's compare note through the process.Tom

Goldberg profile image
Goldberg in reply to tceinvestments

Couple of days pain increased. For the next three/4days diminished to the usual uncomfortable. Part of that is due to a bad disc in my lower back. Calling for shots to that area as it’s not cancer.

tceinvestments profile image
tceinvestments in reply to Goldberg

Thanks for the info.Obviously, I am nervous about starting.

"Survived" chemo last year.

My energy endurance still not back.

Still try to walk or lift weights or golf once a day.

Are you experiencing fatigue???

Are you scheduled to get a blood test for red and white blood cells soon?

Thanks so much for your input.

Hang in there.

Tom

Goldberg profile image
Goldberg

Day 3 after223 feeling better than day 2

tceinvestments profile image
tceinvestments in reply to Goldberg

Oh that is good news.Keep me posted if you think about it.

How long do the injection take?

tceinvestments profile image
tceinvestments in reply to Goldberg

Hi Goldberg:Checking in to see how you are feeling a week or so after your 223 injection.

I get my first one tomorrow.

Thanks,

Tom

tceinvestments profile image
tceinvestments in reply to tceinvestments

Hi Goldberg:

How are you feeling? I hd my first injection 2 weeks ago. Overall, versus chemo, feeling great . Some pelvic bone pain but I don't know if that is 223 or old age. What about you.

Tom

Yadifan profile image
Yadifan

Thank you to all that are posting on this thread. My husband's PSA was 49.1 after this last docetaxel. Xofigo is our next step.

tceinvestments profile image
tceinvestments in reply to Yadifan

How many sessions did he have????What was his PSA when he started?????

Hang in there.

Yadifan profile image
Yadifan in reply to tceinvestments

He had 10 sessions where his PSA got down to 1.2. Got a couple of months off until it climbed back up to 48. This second time of docetaxel his PSA didn't get below 24 and has been slowly climbing every session. He just completed his 11th cycle this 2nd time (21 total) where it went from 42 to 49. He's been tolerating it pretty well considering he's had so much of it. Our next appointment in 2 weeks we'll discuss the next step - which his doc has already mentioned would be Xofigo. He has bone mets and no organ involvement. I'm not sure how much of a break he'll get between the chemo and starting Xofigo, but I guess we'll find out at our next visit. We're still holding out hope to get LU177. His doc is checking into this also.

His PSA at dx was 3300. Initially he had abiraterone and then Xtandi. Both failed after a few months. He's had 2 Foundation One studies. The 2nd one just weeks ago. The results show nothing actionable.

You hang in there also! Hoping you tolerate it well and it helps keep this monster at bay. Keep us posted!

tceinvestments profile image
tceinvestments in reply to Yadifan

Thanks Yadifan. His story is much worse than mine. I quit chemo after 5 sessions because of foot neuropathy. My psa was down to 0,4. Stayed there for 6 months and now 10 again. I too only have bone mets. First injection of 223 yesterday. So far so good. No side effects yet. Hope it works. Please keep me posted. Thanks for your input.Tom

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