I am BRCA2+. Was on Zytiga for just six months after it initially lowered my PSA from 20 to 0.12, but started rising to 0.55. Switched to Olaparib five weeks ago. Also started Provenge 3 weeks ago, just having finished my second of three rounds. PSA now back down to 0.13 probably due to Olaparib and not Provenge.
So glad I had the genetic testing from Color Genomics, which identified my BRCA2+ diagnosis and determined that a PARP inhibitor should be considered as a viable treatment option. Have two daughters who also had the test, and both are BRCA2+. They are proactively pursuing options. While this is devastating to me, it is definitely better for them to know sooner than later and to find viable options.
Had I known sooner that I would be predisposed to aggressive PC I would have had a much earlier biopsy before it rose quickly (6 weeks) from 5.5 to 20, and my then Oncologist didn't see the need. Thankfully I didn't follow his advice and found another Dr. An earlier biopsy may have caught my PC before it spread to my pelvic bone.
Knowledge is power!