Olaparib effectiveness and side effects

[HopingForTheBest1]

Have been on Olaparib for 22 months so far. 400 mg 2x daily. BRCA2+. MSS and low tumor burden rules out Keytruda combo, or by itself, as an effective option.

PSA had been undetectable for 18 months before rising to 1.11 so far. Had Auximin scan 2 days ago. Just one small spot on lung found. Radiologist said this could be the cause of PSA rise, and should be zapped.

Finally having 18F PYL PSMA scan next week as part of trial at Stony Brook. Have been searching for past several months. NIH and Weill Cornell applications were unsuccessful. Trial will compare the 2 scans, and expect PSMA to be more sensitive. Hopefully will not find much more than Auximin but won't be surprised if it does.

Side effects of long term use of Olaparib have been anemia, constipation, memory issues, headaches and fatigue; all tolerable. Especially since it has been very effective.

[Pleroma]

Thanks for your post.

You write that you take 400 mg twice a day. The normal dosage is 300 mg.

Did you at some point increase the dosage?

[HopingForTheBest1 in reply to Pleroma]

Have been on this dosage from day 1.

[p3d1]

That was a good run on Olaparib. Did your team ever mention trying another PARPi like Rucaparib?

If Radiation to your mets which are causing the problem then the tumor may be re sensitized to a PARPi.

This is a SOC treatment for women with Ovarian Cancer and some have had a good response with the second treatment.

Might be worth a shot.

I have finished with Rucaparib but having had a second chemotherapy, spot radiation and now on Radium 223 it may be a possibility for me.

[HopingForTheBest1 in reply to p3d1]

My Oncologist told me that all PARPs work similarly, so using a different PARP would not be effective.

[p3d1]

Check out this facebook page.

PARP INHIBITORS- drugs snd trials

Multiple posts on re challenging with a second PARPi which is FDA approved for ovarian cancer. PARPi’s were trialled in OVC first, they are about 7 years ahead of Prostate cancer and for someone like yourself who had such a fantastic response it may be an option after tackling the small spots which are causing your PSA to rise.

[Curehunter]

Great response. Did you take any supplements to try to keep Olarapib effective for as long as possible.

[HopingForTheBest1]

Yes. Modified Citrus Pectin, fish oil, boswellia extract, Zyflamend, calcium/magnesium, vit D3, ubiquinol CoQ10, probiotics, Turkey Tail, Lion's Mane, green tea extract, liposomal C, broccoli & cruciferous blend, ashwagandha extract.