Olaparib (Lynparza) AND Nubeqa

[sjc2]

My husband has been on Nubeqa for 3 1/2 years now. His PSA is rising again, so MO has ordered another PSMA scan and also did a Guardant 360 liquid biopsy blood test, to hopefully find out what's going on. MO said if something shows up on his scan, he will probably start him on Olaparib (Lynparza) and STOP the Nubeqa (hubby is BRCA2 positive).

My question is why MO will drop Nubeqa, since it's a drug that is different than the PARP inhibitor? I've read some posts on here of men taking them both. Hubby has no prostate, had an orchiectomy 6 yrs ago and radiation after prostate removal 10 yrs. ago and again 1 yr ago for an area near his lung that showed up on PSMA (no chemo yet). Don't want him to take any drugs he doesn't need, but don't want to stop something that could still help.

Have or are you, taking these two drugs together??

Thanks in advance!! 😊

[Tall_Allen]

Email him the links in this article and make an appointment to discuss.

prostatecancer.news/2022/06...

fda.gov/drugs/drug-approval...

They didn't test it with Nubeqa specifically, but it probably isn't much different.

[God_Loves_Me]

Yes - Xtandi + Lynparza works great. I recently talked to doctor

pfizer.com/news/press-relea...

[mrscruffy]

I am also BRCA2 positive. I have been on Lupron and Lynparza for 13 months now. Working well for me

[sjc2 in reply to mrscruffy]

Great! Have you had any issues with side effects from the Lynparza and if so, which ones? Thank you!!

[mrscruffy in reply to sjc2]

Yes, depletion of white and red blood cells, the lack of red cells makes it difficult to breathe while working in the yard. But strangely enough doesn't bother me much in the gym. My MO and I mess with the dose to avoid SE's. All in all not horrible

[mrssnappy]

This interview is about the BRCAAWAY trial that showed good results using the combination of abiraterone and olaparib upfront. In the interview she says using both up front is better than sequential therapy. My husband added lynparza after abiraterone started to fail. He stayed on abiraterone at first but then dropped it. He is now just doing Zoledex and lynparza. PSA has continued to stay low even after dropping the abi. I'm not sure if there are any studies that compare those who were already on abiraterone or Nubeca and either dropped it or stayed on after adding olaparib.

urotoday.com/video-lectures...

[Ian99 in reply to mrssnappy]

Similar to my situation. I was on Zoladex and Zytiga, PSA kept rising. After testing showed BRCA2+, MO asked me to stop Zytiga then start Lynparza, continuing Zoladex. MO considered Zytiga was failing due to rising PSA. Lynparza (w Zoladex) has lowered my PSA (over 7 months) for the first time in years (61->33).

[j-o-h-n]

My M.O. switched me over from Casodex to Nubeqa in the Spring of 2023 but also left me on Lupron. My prostate is currently being pickled in Carnac the Magnificent's hermetically sealed mayonnaise jar on Funk and Wagnalls' porch since it was donated to science 22 years ago. I also had my prostate bed fried in 2005 and so far my PSA is slowly dropping "step by step".

Regarding your dear husband lung issue I just wish to point out that my lung metastasis from a treated melanoma on my neck was treated with Keytruda and it worked. Check it out.

Good Luck, Good Health and Good Humor.

j-o-h-n

[babawinter]

I'm in the same boat... Zoladex + Nubequa for over a year so when PSA began climbing, we added Lynparza. Over the 7 months on the 3, PSA response slowly dropped and has now leveled off. SE since starting all 3... fatigue, difficulty breathing while active, weakness. My sports/fitness activities have slowed down significantly - my MO is good about taking QOL into account so we cut the dose from 4 tabs a day to 3, then eventually to 2. Some improvement in SE's but still difficulty enjoying usual activities. Our plan is to monitor PSA and when it begins climbing, we increase the Lynparza to original dose. I do labs every month when I get Zoladex injections so we can monitor PSA. I get scans every 6 months so we monitor any tumor activity.

PC is a beast and the tumors are very smart... I can almost hear them thinking "ah, we see what you're doing, give us a few months and we'll find a way around these meds!"