PARP treatment for BRCA2-2nd gen bett... - Advanced Prostate...

Advanced Prostate Cancer

22,292 members27,989 posts

PARP treatment for BRCA2-2nd gen better than Olaparib?

HopingForTheBest1 profile image

BRCA2 positive. Have been on Olaparib for 9 months. Great results as PSA undectable for past 7. Newer second generation PARPs now available, which could possibly be more effective? Oncologist doesn't want to change anything at this point; really can't disagree. Don't mess with success.

Another Oncologist had told me that should Olaparib eventually fail, then any other PARPs would probably not work for me. I hope he's wrong.

Written by
HopingForTheBest1 profile image
HopingForTheBest1
To view profiles and participate in discussions please or .
Read more about...
7 Replies
GP24 profile image
GP24

Here is an article discussing these PARP inhibitors:

ascopost.com/issues/march-2...

There is no head-to-head comparison of these drugs yet, so you cannot tell if one is better than the other. I doubt that there is a significant difference between these.

Hope Olaparib continues to work for a long time. Can I just ask what dose you are on?

HopingForTheBest1 profile image
HopingForTheBest1 in reply to

4 100mg tablets 2x daily.

in reply toHopingForTheBest1

I think I was given half of that - so it didn’t help. Onco said at the time he’d like to give me a higher dose, but wasn’t able to at that point in time. Sounds like it might be worth a second crack. Thanks for answering and good luck.

Tall_Allen profile image
Tall_Allen

The various PARP inhibitors are discussed here:

pcnrv.blogspot.com/2019/10/...

None are FDA approved for prostate cancer yet. You are getting it off-label or on a clinical trial. If you are self-funding off-label payment, there is as yet no reason to choose one over any other.

As you can see in the 6 vs 12-month results of the TRITON 2 trial of rucaparib, there is diminished effectiveness over time. However, it is possible that carboplatin will be effective in many of the men in whom a PARP inhibitor is effective.

p3d1 profile image
p3d1

HFTB1,

That is an excellent response to a PARPi. If you look at the TRITON2 poster from ESMO 2019, on the right hand side of the waterfall chart there are only a couple of guys who achieved a 100% reduction in PSA. Most of these guys are still ongoing with treatment.

In the BRCA1/2 group, 3 men (5%) had a complete response.

I hope you are heading for that small group of complete responders.

For 7 months any faulty cells that tried to grow have died, the thing about PARPi is that it is not affecting your PSA doubling time. If your PSA was aggressive before you went on the trial then it is still doubling now. The longer you are holding an undetectable PSA then the more bad cells are being killed off.

in reply top3d1

Thanks for a great explanation .

Not what you're looking for?

You may also like...

Started PARP inhibitor Olaparib and Provenge treatment

I am BRCA2+. Was on Zytiga for just six months after it initially lowered my PSA from 20 to 0.12,...

PARP or immuno for BRCA2+ and NED

Being BRCA2+, I am considering a PARP inhibitor (olaparib) in the hope of killing my (presently...
Purple-Bike profile image

BRCA2 positive - need for PARP inhibitor; Rucaparib, others?

MO told me that I was doing a tremendous job researching my PCa disease, but also suggested I get...

PARP inhibitor Olaparib, phase 3 study findings (PROpel)

While we wait for the next generation PARP inhibitors to become available (I have written about it...
Maxone73 profile image

BRCAAWAY Trial: Abiraterone and Olaparib work way better together than sequentially in mCRPC for BRCA1/2 and ATM

"The median progression-free survival was 39 months. So this is over three years median compared to...
Maxone73 profile image