Update on treatment with Olaparib (Lynparza)

[Arcticfox44]

I've been on Olaparib (Lynparza) for a few weeks. The original plan from Dr. Kwon at the Mayo was to combine Olaparib with Darolutamide (Nubeqa), but I've been unable to get the latter in Cyprus, where I live, and somewhat reluctantly I decided to go with Olaparib alone. PSA was still above 200 in recent blood tests. I'm concerned that Olaparib/Lynparza on its own may not produce much benefit. I've had pronounced swelling of legs and feet, lower-back and knee pain and difficulty walking. I recently started Lasix 20 mg daily, which has reduced swelling. I had to resume the antibiotic Augmentin for UT infection. I had stopped it and switched to Hiprex, but the infection returned. We then resumed Augmentin and it seems to have stopped the infection. I was able to discontinue it this past weekend (March 16). Bleeding from the UT appears to have stopped and I no longer have to use catheters.

I would be interested in others' experiences with Olaparib. My sense is that it may not work in my case, at least on its own) and I plan to return to the Mayo as soon as possible.

[mrscruffy]

I am BRCA2+ Lynparza was effective with Lupron for 14 months

[Tall_Allen]

Many men have to discontinue PARP inhibitors due to toxicity.

[j-o-h-n]

Do a search of our H.U. History file (see top left of screen) for tons of information/posts regarding "experiences with Olaparib".

Good Luck, Good Health and Good Humor.

j-o-h-n

[Ian99]

I am BRCA2+. Your bio makes no mention of a gene mutation but generally this can make Lynparza more effective. I have been taking Lynparza for 10 months, along with Zoladex. I found 600mg a day overwhelming. Since October am on 400mg a day. Tolerable, blood counts ok and keeping the PCa at bay so far.

[RoseDoc]

You may be able to fill the prescription at Mayo, when you are there, if it is not available in your country. It is very expensive without insurance.