Experiences with

Olaparib

move my arms (i walk around like a T.rex) i am now just on olaparib tablets now and i thought the pain might subside but it hasn't, has anybody had this side effect and have you any tips to soothe it etc oh and no painkiller touches it even morphine doesn't help

Our MO has suggested discontinuing the Olaparib during the Lu-177 PSMA therapy due to potential of compounding hematologic SE, however I have come across a couple of articles that suggest Olaparib with Lu-177 works better and there was even a trial to check its safety and efficacy (LuParp ) .

Has anybody undergone or undergoing a combination drug of Olaparib 150 mg 2 tabs 2x a day, Abiraterone Acetate 500mg 2 tabs a day, and Prednisone 5mg 1 tab 2x a day?

Scientists at The Institute of Cancer Research, London, have figured out a way to predict how long prostate cancer patients will benefit from the drug olaparib using a simple blood test.

In a patient who has taken carboplatin and it has not worked at all, does it make sense to try olaparib (lymparza) or is it better not to because if the platinum-based chemotherapy has failed, the parp inhibitor will surely fail too?

The combination also showed a better PSA response compared to olaparib plus abiraterone acetate. However, the article acknowledges the limitations of indirect comparisons and emphasizes the need for further research.

My lovely mum started Olaparib 3 weeks ago and all seemed well for the first couple of weeks (apart from fatigue which we knew to be expected). However since Boxing Day she’s been throwing up most mornings. Has anyone else had this issue? Any advice?

Kwon has recommended starting both darolutamide and olaparib. It appears that there will be no problem getting olaparib here, but there may be a problem getting darolutamide in Cyprus. My oncologist here hopes that if we can present Dr.

MO said if something shows up on his scan, he will probably start him on Olaparib (Lynparza) and STOP the Nubeqa (hubby is BRCA2 positive). My question is why MO will drop Nubeqa, since it's a drug that is different than the PARP inhibitor? I've read some posts on here of men taking them both.

I originally had Paclitaxol/ Carboplatin followed by two years on Olaparib. I’m extremely anxious as after my third session I seem to have become allergic to Carboplatin followed by. My Oncologist is going to try me on Cisplatin for the last two cycles.

I am really scared at the moment , if the Olaparib is keeping the cancer activity in check to some degree , what on earth is going to happen when I finish the 2 year allotted time on it.

She had caeboplatin 4 cycles, then olaparib for 2 years, then debulking surgery in August this year and 6 doses of Carboplatin. However, recent scan showed it has progressed and deemed carboplatin resistant. Oncologist has suggested Liposomal Doxorubicin.

Just wondering if anyone has experience with olaparib? I now have metastases in my liver as well as bones. I started carboplatin chemo last week after failed docetaxel and carparvotaxel treatments. Olaparib has been mentioned as a possible treatment.

We found out that she is HRD+ (not BRCA) so will be being put on Olaparib + Bev. Has anyone had this maintenance - how has it worked for you? Thanks :)

https://ascopost.com/news/august-2024/olaparib-may-be-effective-without-hormone-therapy-in-some-men-with-biochemically-recurrent-prostate-cancer/

https://www.hopkinsmedicine.org/news/newsroom/news-releases/2024/08/precision-drug-olaparib-may-be-effective-without-hormone-therapy-for-some-men-with-biochemically-recurrent-prostate-cancer

I’m nervous after Protein blocker Olaparib failed and I’ve been back on Chemotherapy. He’s seeing me on the 10th with hopefully results from my CT scan. I would welcome any advice or information from you kind ladies.

Disappointing especially as Olaparib also didn’t work for me in 2023. After being mostly bald for the past two years (was told Caelyx wouldn’t lose my hair!). As I now have grown hair back I’m trying the cold cap with correct size cap.

On chemo and then 2 years of Olaparib, I developed peripheral motor neuropathy from knee to ankle and needed to use walking stick for heavy legs and resulting poor balance (previously walking like Miss Skippy Toes). 4 months after my last Olaparib (Jan 2024) , my walking was slightly improving as nerve

In addition, olaparib offers decreased hypertension when superimposed on ADT + abiraterone acetate + prednisone for mCRPC treatment after prior androgen deprivation from mHSPC therapy.