How are you doing with the erleada? I am two months into this drug and I am seeing the same side effects as Lupron, They are fatigue,head cold,and hot flashes. Yesterday I awoke to the room spinning,but that is better today.
After DRE, then MRI and resulting biopsy determined Gleason scores of 4+5=9, though PSA was only 4.4 or so, I opted for JHUH RP in Dec 2017. Histology determined invasion of one seminal vesicle, negative for lymph nodes and negative surgical margins, I was staged T3b. Surgery resulted in ED and severe incontinence, the latter improving over time to partial sphincter control, enough to forestall voiding but not enough to control slow, cumulative drip. Have to wear 2 Depends per day. Will avoid complaining. Also developed 7 cm lymphocele (seroma of lymphatic fluid) from the surgery, which according to most recent CT scan, seems to have reabsorbed.
PSA after RP was <1. In ensuing 10 months PSA rose from 0.02 to 0.04. to 0.05 to 0.08 to 0.12, at which time I consulted MO and top RO. Though PSA still low, RO ordered Axumin PET scan, which was negative for mets, and suggested I do 39 radiation treatments aimed at the prostate bed, while MO was not convinced. Very wary of radiation, I opted for MO's treatment. (Will it be my undoing?) Started 30 mg ELIGARD injection (four months, time release - same as Lupron Depot)) and 50 mg BICALUTAMIDE, followed by another four month ELIGARD injection. However, as the FDA recently approved the drug ERLEADA for NON-MET PCa, MO, switched me from 50 mg bicalutamide to 240 mg ERLEADA.
PSA has remained stable at 0.02. For now.
My own experience with ERLEADA side effects is not positive. I have double the hot flashes I had with the ELIGARD-BICALUTEMIDE combo, increased cognitive impairment, am less sure on my feet, and, as someone with GERD and a hiatal hernia (Reflux disease) for many years (well treated by 20 mg OMEPRAZOLE, since years OTC) I find that within minutes of taking ERLEADA it immediately pushes up the production of stomach acid, while at the same time cutting the action of OMEPRAZOLE by as much as 85% (according to the literature.)
So, even with smaller and earlier-in-the-day meals, I experience daily burning in throat and chest, sometimes mouth. As some years ago I had Barretts Esophagus (invasion of lower esophagus by pre-cancerous cells) but it retreated, the specter of possible future esophageal cancer now reappears. I have shortness of breath from the newly increased GERD symptoms and my quality of life has deteriorated. I decreased daily dose of ERLEADA to 120mg, but reflux symptoms persist. Will have to revisit ERLEADA with MO , when I see him next week. He's a big fan of ERLEADA because of the SPARTAN trial.
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