Erleada vs Xtandi - what are the diff... - Advanced Prostate...

Advanced Prostate Cancer
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Erleada vs Xtandi - what are the differences?

In light of the fact that Erleada has just been approved for both HRMPC and Non-MPC, I think it would he helpful to all of us to understand what the differences and similarities are between these two drugs.

I just came off of the Titan Study for Erleada used for those of us with MPC, and so will be watching this with great interest. I was not eligible for the Erleada because I have already been switched over to Zytiga...but Erleada and Xtandi will be potential options for me in the future.

1. Will those who have taken Xtandi but have grown resistant- now get a benefit from Erleada in the future? Or vice versa?

2. Does one drug have less side effects or will they generally be the same?

3. What will the cost difference be?

4. There is a preferred order that these newer drugs and additional Chemo need to be taken in as one may reduce effectiveness of another. We need a flowchart showing the latest and most effective treatment plans for various stages each of us are in.

I am meeting with my oncologist again next week and will be asking her these questions.

But if others have had experience with or have researched these two drugs I would be curious to learn as much as we can.

7 Replies

These prescribing information links could be a touchstone for those looking further into such questions.



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Very similar. They may have different side effects. I think apalutamide has less neurological complications, such as seizures than enzalutamide.

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All of these drugs may have interactions with each other and should be carefully considered by you and your MO as to what is taken and in what order and circumstances.

Good luck.


Excellent questions to ask. Hope there iis any info you get from your onc. or this group that is passed on to us. I know some who failed casodex still got a pos. response from nylutamide or xtandi so these there seems. To be no cross. restance and may be the same for ampulutamide and upcoming daralutamide so these drugs CAN be manipulated before going on to castration adt with lupron. Rocco


Excellent question. I’m in the same situatio. I’ve been on xtandi for two years but my PSA is starting to rise. Sorry I don’t have an answer for your question as I am also looking for options.


Took a peak into your past and I congratulate you sir. You have had an amazing journey. Xtandi has done well for me for 18 months now, although I believe I am in more dire straits than you are. I wish you a long, long journey. Enjoy.


Yeah...I’m on YouTube talking about my journey to a PCa support group. I hope you do well and find something that brings your PSA under control. My best.


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