Experiences with

Opdivo

I wonder if anyone here can comment on their experience with yervoy/opdivo? Did it help you? Did you have manageable side effects?

I was taking Opdivo immunotherapy from 2/2023 to 2/2024 for bladder cancer. so far my bladder cancer is in check so now I can focus on my PCA. Should I get a PSMA pet? is it time to start ADT + Abi and prednisone?

A cystectomy in 01/2023 due to bladder cancer, one year of immunotherapy with Opdivo, and back surgery for sciatica in June 2024 in addition, I now a hernia under the stoma. Am I making the right decision? your help is appreciated.

just wanted to provide an update on using immunotherapy, in my case Opdivo and Yervoy. Some background: 6 years after my initial diagnosis of OVCA, it was discovered via a raised CA125 and subsequent CT Scan, that I had developed 3 tumors on my Psoas muscle of my back.

He says there are other pills I can choose to take instead, such as Zytiga with a parp inhibitor, Opdivo or Nirapared, but still thinks the chemo or clinical trial are better choices for me. I'm getting a second opinion, but any insights you guys might have would be helpful. Thanks, Joe Mason

Surprisingly enough, drugs that can block CCL20 may also reduce autoimmune side-effects from standard PD-1 immunotherapy, such as and Keytruda.

Nivolumab (Opdivo): Nivolumab is another checkpoint inhibitor that targets PD-1. Like pembrolizumab, nivolumab has been studied in clinical trials for advanced prostate cancer, often in combination with other therapies.

A decision will be made after my second Opdivo infusion and another PSA test and PT scan.

A biologics license application (BLA) has been accepted by the FDA seeking approval of nivolumab (Opdivo) co-formulated with Halozyme’s proprietary recombinant human hyaluronidase (rHuPH20; subcutaneous nivolumab) for adult patients with solid tumors eligible for previously approved nivolumab indications

He did infusions of the immunotherapy drug (Opdivo) for 8 months and then was pulled out of the trial because of adverse side effects. He did monthly Firmagon shots until the pill form, Orgovyx, became available and now that is all he takes to manage his prostate cancer.

Roger kept getting weaker and weaker. He was hospitalized, the sent to a rehab, then to another hospital due to breathing trouble, then home to die in 2 days. It was a quick ending to an honorable and graceful life. He was in his 80's, but until he had Melanoma - he seemed very young and strong. God

Marks cancer is back his liver is full In 2017 when Mark was 1st diagnosed it was everywhere, but his Brain so he was 1st put on Opdivo/ Yervoy. Stopped Yervoy after 2 treatments. And a month or so later put on BRAF meds for about 6 months together. Then continued Opdivo alone for another year.

On March 4th, 2022, the Food and Drug Administration (FDA) approved Opdivo (nivolumab) for treatment before surgery in combination with platinum-based chemotherapy in patients with stage IB to IIIA non-small cell lung cancer (NSCLC).

He had his 5th Opdivo infusion and will have the 6th one in 2 weeks. Then we have an MRI scheduled for March 1 and praying that it will show shrinkage of the tumors or at least that they're stable. I'm working on a couple of interesting projects with AstraZenica this month.

Insurance denied the Tecentriq and Avastin combo at last minute so we're going with Opdivo instead. His insurance company is changing at end of month so Oncologist says can always try again for approval with new company. He wanted to start something though ASAP so I guess it's better than nothing.

He has to go for blood work next week and then sees the Dr on the 11th to discuss how the Opdivo is working. No matter what, nothing can take away the wonderful memories of this holiday season. Sharon 💖🥳

One kind soul used that to explain how -mab described a monoclonal antibody (think Nivolumab/Opdivo). He went on to teach me that the suffix -nib means the drug is an inhibitor like afatnib which is used as a TKI inhibitor(also know as Gilotrif). So today I read this blog about naming drugs.

Since the chemotherapy was not working, and with little precedent, I was put on immunotherapy (Opdivo) and Lupron, and my PSA went from 21 to 0.11 after one treatment. After the 0.11 reading, my PSA readings for the next thirteen months were “undetectable”.

The free Opdivo trial offered by MaleCare is similar to the trial Steve was on and worth the try if you qualify.

I do wonder if this is in regards to CHECKMATE 650 and the decreased responsiveness to Yervoy and Opdivo by patients that had been treated with docetaxel. At this point, maybe there is no take home message from PEACE I..... Don Pescado