Any thoughts as to why increasing liothyronine (extended release) by just 1 mcg makes me hyper, but when not taking it I’m hypo?

[marlyn123]

I am taking 9.79 mcg liothyronine extended release plus .125 mcg generic synthroid in a.m. for Hashimoto's. In the afternoon I was taking 8.79 mcg liothyronine and crashing by mid-afternoon. When I try increasing to 9.79 in the afternoon I feel ‘normal’, can do what I need to do, but feel anxious, slightly hyper and occasionally have a headache. I have tried this increase several times with the same result and am too uncomfortable with how I felt. I also take iron, zinc, and D.

This is my first post--I hope I have included necessary info. After decades of only synthroid and being constantly fatigued, cytomel has helped me to start waking up. Thanks for any help.

VITAMIN D,25-OH,TOTAL,IA 70 Reference Range: 30-100 ng/mL

HEMOGLOBIN 13.2 Reference Range: 11.7-15.5 g/dL

MCHC 32.8 Reference Range: 32.0-36.0 g/dL

FERRITIN 90 Reference Range: 16-288 ng/mL

IRON, TOTAL 97 Reference Range: 45-160 mcg/dL

IRON BINDING CAPACITY 295 Reference Range: 250-450 mcg/dL (calc)

ZINC, RBC 10.3 Reference Range: 9.0-14.7 mg/L

VITAMIN B12 951 Reference Range: 200-1100 pg/mL

FOLATE, SERUM 13.9 Reference Range Low: <3.4 Borderline: 3.4-5.4

Normal: >5.4 Show Less

TSH 0.01 L THYROGLOBULIN ANTIBODIES 2 H Reference Range: 0.40-4.50 mIU/L

T4, FREE 1.8 Reference Range: 0.8-1.8 ng/dL

T3, FREE 3.4 Reference Range: 2.3-4.2 pg/mL

THYROID PEROXIDASE ANTIBODIES 7 Reference Range: <9 IU/mL

[radd]

marlyn123,

Welcome to our forum. Iron & nutrient results all look great.

FT3 is 58% through range and FT4 is at top of range. If that tiny T3 increase makes you feel hyper then maybe you are crossing a threshold. I myself would feel better with slightly lower FT4 levels.

How long since you introduced T3?

When was blood drawn in relation to previous T4/T3 dose taken?

[marlyn123 in reply to radd]

Thank you for your reply. I added T3 to the generic synthroid a year and a half ago, but have been tweaking the dose ever since to try to feel good but without being hyper. Blood was drawn around 8:30 am, 24 hr after t4 dose and about 18 hr after T3. Guess i need to ask my doc about backing off on the synthroid a bit. Thanks for your input.

[Imaaan]

FERRITIN 90 Reference Range: 16-288 ng/mL

^^^Could it be that your ferratin levels arent optimal and its preventing your from any increase???? Youre at 90 and midway would be 152.

[marlyn123]

worth a try. Thank you for that!