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Help with results please

Clark77 profile image
8 Replies

Results

Free T4 pmol/ (9.0-19.0 ref range) 13.2

Free T3 pmol/ (2.89-5.65 ref range) 4.33

APAntibody U/ml (<=6 ref range) 344 (high but now down from <1000)

Vit D nmol/ (≥50-200 ref range) 95.9

B12 pmol/L (170-600 ref range) 1351 (very high)

TSH miu/L (0.35-4.30 ref range) 2.41

Ferritin ug/L (6.5-204.0 ref range) 17.52

(i am in Canada from UK)

Fasted or 12 hours before

I did not take my synthroid before blood test and was on no B vitamins

Not on soy, gluten, sugar

Thoughts and feedback please

Any ideas why such a high b12?

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Clark77
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8 Replies
SeasideSusie profile image
SeasideSusieRemembering

Clark77

Did you get an increase in your dose of Levo after you last posted?

If so what dose are you on now?

Are these new tests since an increase?

You are still undermedicated according to the results. The aim of a treated Hypo patient on Levo only, generally, is for TSH to be 1 or below with FT4 and FT3 in the upper part of their reference ranges if that is where you feel well.

Ferritin ug/L (6.5-204.0 ref range) 17.52

Are you sure about that result? Last time you posted it was 175.2

No idea why B12 is so high. Mine was high and the Advanced Nurse Practioner was concerned until I told him there was B12 in my B Complex. You might want to discuss your result with your GP and he should investigate if necessary.

Clark77 profile image
Clark77 in reply to SeasideSusie

Hi SusieThank you for your reply

no increase still on 25mcg of Levo (and it's good to see so much change in antibodies at that dose and my TSH has come down from over 6 which is also encouraging).

Ferritin same reading as before so no change (whoops typo 17.52).

what numbers classify upper ranges in free t3 and t4? need more clarity on that exactly.

Also I don't feel unwell anymore.

SeasideSusie profile image
SeasideSusieRemembering in reply to Clark77

Clark77

what numbers classify upper ranges in free t3 and t4? need more clarity on that exactly.

I would say about 70% through range, maybe more if that's where it needs to be for you. But it's not just down to numbers, it's also how you feel and if your symptoms have abated.

You can work out percentage through range with this calculator:

chorobytarczycy.eu/kalkulator

Currently you are:

Free T4 pmol/ (9.0-19.0 ref range) 13.2 = 42%

Free T3 pmol/ (2.89-5.65 ref range) 4.33 = 52.17%

Also I don't feel unwell anymore.

Well in that case maybe 25mcg is enough for you at the moment if you feel there is no room for further improvement.

Clark77 profile image
Clark77 in reply to SeasideSusie

Excellent Thank you for the information.

SlowDragon profile image
SlowDragonAdministrator

You need 25mcg dose increase in levothyroxine and bloods retested 6-8 weeks later

Standard starter dose of levothyroxine is 50mcg

Dose levothyroxine is increased slowly upwards in 25mcg steps until on approx 1.6mcg Levo per kilo of your weight

Bloods should be retested 6-8 weeks after each dose change or brand change in levothyroxine

TSH should be under 2 as an absolute maximum when on levothyroxine

gponline.com/endocrinology-...

Replacement therapy with levothyroxine should be initiated in all patients to achieve a TSH level of 0.5-2.0pmol/L.

New NHS England Liothyronine guidelines July 2019 clearly state on page 13 that TSH should be between 0.4-1.5 when OPTIMALLY treated with just Levothyroxine

Note that it says test should be in morning BEFORE taking levothyroxine

Also to test vitamin D, folate, B12 and ferritin

sps.nhs.uk/wp-content/uploa...

Dr Toft, past president of the British Thyroid Association and leading endocrinologist, states in Pulse Magazine,

"The appropriate dose of levothyroxine is that which restores euthyroidism and serum TSH to the lower part of the reference range - 0.2-0.5mU/l.

In this case, free thyroxine is likely to be in the upper part of its reference range or even slightly elevated – 18-22pmol/l.

Most patients will feel well in that circumstance.

But some need a higher dose of levothyroxine to suppress serum TSH and then the serum-free T4 concentration will be elevated at around 24-28pmol/l.

This 'exogenous subclinical hyperthyroidism' is not dangerous as long as serum T3 is unequivocally normal – that is, serum total around T3 1.7nmol/l (reference range 1.0-2.2nmol/l)."

(That’s Ft3 at 58% minimum through range)

You can obtain a copy of the articles from Thyroid UK email print it and highlight question 6 to show your doctor



please email Dionne at

tukadmin@thyroiduk.org

SlowDragon profile image
SlowDragonAdministrator

Do you normally take levothyroxine waking or at bedtime

Many people take Levothyroxine soon after waking, but it may be more convenient and perhaps more effective taken at bedtime

verywellhealth.com/best-tim...

No other medication or supplements at same as Levothyroxine, leave at least 2 hour gap.

What vitamin supplements are you currently taking?

When were vitamin D, folate, ferritin and B12 last tested

Some supplements like iron, calcium, magnesium, HRT, omeprazole or vitamin D should be four hours away from levothyroxine

(Time gap doesn't apply to Vitamin D mouth spray)

If you normally take levothyroxine at bedtime/in night ...adjust timings as follows prior to blood test

If testing Monday morning, delay Saturday evening dose levothyroxine until Sunday morning. Delay Sunday evening dose levothyroxine until after blood test on Monday morning. Take Monday evening dose levothyroxine as per normal

REMEMBER.....very important....stop taking any supplements that contain biotin a week before ALL BLOOD TESTS as biotin can falsely affect test results - eg vitamin B complex

greygoose profile image
greygoose

Re antibodies, they fluctuate all the time, and their fluctuation has next to nothing to do with your dose, your TSH or your Free numbers. In fact, the fact that they've gone down is pretty meaningless, they'll probably go up again. But, even if they went away completely, you'd still have Hashi's. That doesn't go away, I'm afraid.

Clark77 profile image
Clark77

Thank you for your response. No it doesn't go away apparently; however it can and does go into remission, as stated very clearly by Dr Izabella Wentz. If we have a clear and concise protocol that we work with, lets us at least know that remission is possible fortunately.

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