I've recently started supplementing with B12, B complex, selenium and D3 as suggested by this forum. I take the B vitamins and selenium at night when I take my thyroxine and the D3 at lunchtime. Last night I woke every hour throughout the night and am wondering if this is common when starting vitamins? I have looked here for info re time to take supplements and I saw it said that D3 should be at least 4 hours away from thyroxine. I'm also wondering how long I should wait to see if there is any change in my fatigue before adding a little T3 to my T4?