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Phase 2 trial: Evaluation of Treatment Interruption After Response in mHSPC
"Patients are allowed to enrolle if they have a stable or falling prostate-specific antigen (PSA) level below 0.2 ng/mL and a castrate
testosterone
level under 50 ng/dL at baseline after having a PSA level of at least 5 ng/mL and a
testosterone
level of at least 150 ng/dL prior to the start of ADT. "
"Patients are allowed to enrolle if they have a stable or falling prostate-specific antigen (PSA) level below 0.2 ng/mL and a castrate
testosterone
level under 50 ng/dL at baseline after having a PSA level of at least 5 ng/mL and a
testosterone
level of at least 150 ng/dL prior to the start of ADT. "
Maxone73
in
Advanced Prostate Cancer
29 days ago
Post radiation and low(er) testosterone
My
testosterone
is sitting in the low 300's so on the low end of the reference range but still within it. I had been on
testosterone
replacement prior to the prostate cancer diagnosis for the better part of 10 years but had tapered that off after the diagnosis.
My
testosterone
is sitting in the low 300's so on the low end of the reference range but still within it. I had been on
testosterone
replacement prior to the prostate cancer diagnosis for the better part of 10 years but had tapered that off after the diagnosis.
TonyTx
in
Prostate Cancer Network
1 month ago
Testosterone Gel - Any positive results from use?
My fertility clinic have suggested that I use
testosterone
gel for my next cycle to improve egg quality - does anyone have any success stories with IVF after using
testosterone
gel?
My fertility clinic have suggested that I use
testosterone
gel for my next cycle to improve egg quality - does anyone have any success stories with IVF after using
testosterone
gel?
MD54999
in
Fertility Network UK
4 months ago
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Is there such a thing as too fast of a recovery of T on iADT 🫨
Otherwise known as "taking a vacation".I am now 10 weeks without ADT, and my
testosterone
is already at 104. My questions this time are for others here who have had a similarly quick return of
testosterone
.
Otherwise known as "taking a vacation".I am now 10 weeks without ADT, and my
testosterone
is already at 104. My questions this time are for others here who have had a similarly quick return of
testosterone
.
Lewellen
in
Advanced Prostate Cancer
4 months ago
Progesterone with irregular period
hello all, I’ve recently started
testosterone
cream and now my period is every 2 weeks. When do I take progesterone if my period is fortnightly? I was taking progesterone on day 14 to 25 of my cycle previously 🤷🏼‍♀️
hello all, I’ve recently started
testosterone
cream and now my period is every 2 weeks. When do I take progesterone if my period is fortnightly? I was taking progesterone on day 14 to 25 of my cycle previously 🤷🏼‍♀️
Thyroid_mum
in
Menopause and Perimenopause Support
1 month ago
PSA relapse rate vs testosterone nadir - 3
(ref: 2019) The
best
outcomes
are significantly associated with a
lower
nadir ( < 20 ng/dL), and the relationship appears to be roughly linear; heading toward a zero relapse rate for a
testosterone
nadir = 0.
(ref: 2019) The
best
outcomes
are significantly associated with a
lower
nadir ( < 20 ng/dL), and the relationship appears to be roughly linear; heading toward a zero relapse rate for a
testosterone
nadir = 0.
janebob99
in
Advanced Prostate Cancer
5 months ago
PSA Survival vs Testosterone Nadir - 2
(ref: 2019) The
best
outcomes
are significantly associated with a
lower
nadir ( < 20 ng/dL), and the relationship appears to be roughly linear; heading toward a 100 % survival rate for a
testosterone
nadir = 0.
(ref: 2019) The
best
outcomes
are significantly associated with a
lower
nadir ( < 20 ng/dL), and the relationship appears to be roughly linear; heading toward a 100 % survival rate for a
testosterone
nadir = 0.
janebob99
in
Advanced Prostate Cancer
5 months ago
CLL, Alcalabrutinib, Low Testosterone
My haematologist has never once accepted that what im experiencing is a side effect of acalabrutinib, instead refers me to my GP Ok rant over Ive now got low
testosterone
, which explains a lot, anyone else with similar experiences and does replacement therapy have any downsides” Thank you, for your
My haematologist has never once accepted that what im experiencing is a side effect of acalabrutinib, instead refers me to my GP Ok rant over Ive now got low
testosterone
, which explains a lot, anyone else with similar experiences and does replacement therapy have any downsides” Thank you, for your
Tomaljoe69
in
CLL Support
2 months ago
PSA Rising
PSA went from <.02 to currently .27,
Testosterone
at about 600+ Since surgery, there has been no intervention. It looks like it is time to take action. Does the group have any suggestions?
PSA went from <.02 to currently .27,
Testosterone
at about 600+ Since surgery, there has been no intervention. It looks like it is time to take action. Does the group have any suggestions?
Gulfrider
in
Prostate Cancer Network
1 month ago
PSA drop with decreasing Testosterone after Estrogen Patch Therapy
It plots the % reduction in PSA from baseline (100%) at time = 0 as a function of
testosterone
levels over a period of 4 weeks. As you know, estrogen effectively castrates men, causing a drop in
testosterone
over time to castrate levels (< 50 ng/dL).
It plots the % reduction in PSA from baseline (100%) at time = 0 as a function of
testosterone
levels over a period of 4 weeks. As you know, estrogen effectively castrates men, causing a drop in
testosterone
over time to castrate levels (< 50 ng/dL).
janebob99
in
Advanced Prostate Cancer
5 months ago
PSA drops with decreasing Testosterone
It plots the % reduction in PSA from baseline (100%) at time = 0 as a function of
testosterone
levels over a period of 4 weeks. As you know, estrogen effectively castrates men, causing a drop in
testosterone
over time to castrate levels (< 50 ng/dL).
It plots the % reduction in PSA from baseline (100%) at time = 0 as a function of
testosterone
levels over a period of 4 weeks. As you know, estrogen effectively castrates men, causing a drop in
testosterone
over time to castrate levels (< 50 ng/dL).
janebob99
in
Prostate Cancer Network
5 months ago
interesting even if not applicable yet: Breakthrough rice bran nanoparticles show promise as affordable and targeted anticancer agent
cheap an ingenious, I don’t know if normal oral gamma-oryzanol is safe for us as it’s also a
testosterone
stimulant… https://www.sciencedaily.com/releases/2024/04/240422120640.htm
cheap an ingenious, I don’t know if normal oral gamma-oryzanol is safe for us as it’s also a
testosterone
stimulant… https://www.sciencedaily.com/releases/2024/04/240422120640.htm
Maxone73
in
Advanced Prostate Cancer
3 months ago
Question in Preparation for pBAT
“Free
testosterone
should be >40 ng/dL and bioavailable
testosterone
should be >1030 ng/dl” (p.57 of the online book on BAT). Should I increase the dosage of T propionate to 75 gm? Or should I try to lower SHBG? Or something else?? Thanks in advance for the advice!
“Free
testosterone
should be >40 ng/dL and bioavailable
testosterone
should be >1030 ng/dl” (p.57 of the online book on BAT). Should I increase the dosage of T propionate to 75 gm? Or should I try to lower SHBG? Or something else?? Thanks in advance for the advice!
Ichthus316
in
Fight Prostate Cancer
4 months ago
Testosterone and PCa risk - 3
So, for example, for the lower plot (high risk), a
testosterone
level of 100 ng/dl, the Odds Ratio = 7, meaning that a man with 100 ng/dL will be 7 times more likely to get high-risk PCa than a man with a
testosterone
of 1000 ng/dL.
So, for example, for the lower plot (high risk), a
testosterone
level of 100 ng/dl, the Odds Ratio = 7, meaning that a man with 100 ng/dL will be 7 times more likely to get high-risk PCa than a man with a
testosterone
of 1000 ng/dL.
janebob99
in
Advanced Prostate Cancer
5 months ago
Testosterone and PCa Risk - 3
So, for example, for the lower plot (high risk), a
testosterone
level of 100 ng/dl, the Odds Ratio = 7, meaning that a man with 100 ng/dL will be 7 times more likely to get high-risk PCa than a man with a
testosterone
of 1000 ng/dL.
So, for example, for the lower plot (high risk), a
testosterone
level of 100 ng/dl, the Odds Ratio = 7, meaning that a man with 100 ng/dL will be 7 times more likely to get high-risk PCa than a man with a
testosterone
of 1000 ng/dL.
janebob99
in
Prostate Cancer Network
5 months ago
The struggle is over for my husband at 64
If you look at our profile, we tried everything and finally I gave him some
testosterone
gel during his last week on earth.
If you look at our profile, we tried everything and finally I gave him some
testosterone
gel during his last week on earth.
Chris_Ali
in
Advanced Prostate Cancer
3 months ago
Testosterone and PCa - 2
This plot shows a Kaplan-Mier Prostate Cancer Mortality Survival plot for three different levels of baseline
testosterone
: Low-T, IntermediateT, and Normal-T. The best survival is for men with Normal
testosterone
levels at baseline, and the worst survival is for men with low-T.
This plot shows a Kaplan-Mier Prostate Cancer Mortality Survival plot for three different levels of baseline
testosterone
: Low-T, IntermediateT, and Normal-T. The best survival is for men with Normal
testosterone
levels at baseline, and the worst survival is for men with low-T.
janebob99
in
Prostate Cancer Network
5 months ago
Testosterone and PCa risk - 2
This plot shows a Kaplan-Mier Prostate Cancer Mortality Survival plot for three different levels of baseline
testosterone
: Low-T, IntermediateT, and Normal-T. The best survival is for men with Normal
testosterone
levels at baseline, and the worst survival is for men with low-T.
This plot shows a Kaplan-Mier Prostate Cancer Mortality Survival plot for three different levels of baseline
testosterone
: Low-T, IntermediateT, and Normal-T. The best survival is for men with Normal
testosterone
levels at baseline, and the worst survival is for men with low-T.
janebob99
in
Advanced Prostate Cancer
5 months ago
how to reduce testosterone after orchiectomy
Questions is How to reduce
testosterone
after Orchiectomy ?
Questions is How to reduce
testosterone
after Orchiectomy ?
God_Loves_Me
in
Advanced Prostate Cancer
3 months ago
PSA vs Testosterone at high T levels - Linear Model
This is a plot of PSA versus
Testosterone
in men with prostate cancer. The blue points are taken from a YouTube video lecture by A. Morgentaler (2020). https://www.youtube.com/watch?
This is a plot of PSA versus
Testosterone
in men with prostate cancer. The blue points are taken from a YouTube video lecture by A. Morgentaler (2020). https://www.youtube.com/watch?
janebob99
in
Advanced Prostate Cancer
5 months ago
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