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Reference Library of Papers about Dutasteride for Treating Prostate Cancer
Here is a library of 20 papers about using Dutasteride to treat prostate cancer. In one study, Dutasteride monotherapy reduces PSA by 50%, reduces prostate volume by 25%, and reduces tumor volume by 30%, after 6 months of treatment, compared to placebo (Moore, 2017). https://pubmed.ncbi.nlm.nih.gov
Here is a library of 20 papers about using Dutasteride to treat prostate cancer. In one study, Dutasteride monotherapy reduces PSA by 50%, reduces prostate volume by 25%, and reduces tumor volume by 30%, after 6 months of treatment, compared to placebo (Moore, 2017). https://pubmed.ncbi.nlm.nih.gov
janebob99
in
Advanced Prostate Cancer
6 months ago
Why don't doctors prescribe Dutasteride more often?
I get this question from a lot of men that have prostate cancer. Although the black label warning is a concern to some doctors, and has been discussed here in previous posts, I think the main reason is simply that most doctors don't know about it. Here is the single best paper reviewing the three major
I get this question from a lot of men that have prostate cancer. Although the black label warning is a concern to some doctors, and has been discussed here in previous posts, I think the main reason is simply that most doctors don't know about it. Here is the single best paper reviewing the three major
janebob99
in
Prostate Cancer Network
6 months ago
Two week post SBRT update
Hello All, I completed my 5 SBRT sessions on 5/1/2024. My results have been very similar to ToolBeltZia so I have not posted repetitive daily entries. Here are some items that may be of interest. 1) Very similar issues with constipation as ToolBeltZia had following SBRT. That is just now improving
Hello All, I completed my 5 SBRT sessions on 5/1/2024. My results have been very similar to ToolBeltZia so I have not posted repetitive daily entries. Here are some items that may be of interest. 1) Very similar issues with constipation as ToolBeltZia had following SBRT. That is just now improving
Info_Search_JMA
in
Prostate Cancer Network
4 months ago
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Dutasteride reduces PSA by 40% over 6 months
This companion chart from data reported in Moore (2017) compares PSA, at baseline and at 6 months, comparing placebo to Dutasteride. This was a randomized, double-blind, placebo-controlled clinical trial. The cohort included Low and Intermediate Risk men, GS-6-7, baseline PSA = 6-7, median age 64 y.o
This companion chart from data reported in Moore (2017) compares PSA, at baseline and at 6 months, comparing placebo to Dutasteride. This was a randomized, double-blind, placebo-controlled clinical trial. The cohort included Low and Intermediate Risk men, GS-6-7, baseline PSA = 6-7, median age 64 y.o
janebob99
in
Prostate Cancer Network
6 months ago
Dutasteride Reduces Tumor Volume by 30% after 6 months.
This chart compares prostate cancer tumor volume measured by MRI, at baseline and at 6 months, comparing placebo to Dutasteride. This was a randomized, double-blind, placebo-controlled clinical trial. The cohort included Low and Intermediate Risk men, GS-6-7, baseline PSA = 6-7, median age 64 y.o,
This chart compares prostate cancer tumor volume measured by MRI, at baseline and at 6 months, comparing placebo to Dutasteride. This was a randomized, double-blind, placebo-controlled clinical trial. The cohort included Low and Intermediate Risk men, GS-6-7, baseline PSA = 6-7, median age 64 y.o,
janebob99
in
Prostate Cancer Network
6 months ago
Dutasteride Black Box Warning Label is Inappropriate.
This plot that I made goes back to the original paper by Thompson et al. (2003), that was the basis for slapping the Black Box Warning Label on Dutasteride prescriptions. https://pubmed.ncbi.nlm.nih.gov/12824459/ There are some important points that should be considered: (1) Thompson only studied
This plot that I made goes back to the original paper by Thompson et al. (2003), that was the basis for slapping the Black Box Warning Label on Dutasteride prescriptions. https://pubmed.ncbi.nlm.nih.gov/12824459/ There are some important points that should be considered: (1) Thompson only studied
janebob99
in
Prostate Cancer Network
6 months ago
Perineum Irritation / Pain
I’m Stage 4A prostate cancer (spread outside prostate to lymph nodes only) in week 3 of treatment. I’m doing Lupron shots every 3months + Abiraterone with Prednisone daily, will start radiation in a couple weeks. I was tested on day 8 and my PSA had already fallen from 8.7 to 2.78. I had been feeling
I’m Stage 4A prostate cancer (spread outside prostate to lymph nodes only) in week 3 of treatment. I’m doing Lupron shots every 3months + Abiraterone with Prednisone daily, will start radiation in a couple weeks. I was tested on day 8 and my PSA had already fallen from 8.7 to 2.78. I had been feeling
Willie51
in
Prostate Cancer And Gay Men
5 months ago
Dutasteride Monotherapy is effective for Newly Diagnosed PCa men not on ADT
This plot shows men that either don't have PCa (Group A) or newly diagnosed men with PCa by biopsy (Group B). Neither group is on ADT. Dutasteride monotherapy (0.5 mg/day) causes an average drop in PSA of about 50% in both Groups, and an average drop of about 20% in prostate volume. In one man, his
This plot shows men that either don't have PCa (Group A) or newly diagnosed men with PCa by biopsy (Group B). Neither group is on ADT. Dutasteride monotherapy (0.5 mg/day) causes an average drop in PSA of about 50% in both Groups, and an average drop of about 20% in prostate volume. In one man, his
janebob99
in
Prostate Cancer Network
6 months ago
Dutssteride increases PSA Doubling Time by 2X for men with PSA Failure.
These two Kaplan-Meier plots compare Dutasteride (0.5 mg/day) to Placebo in a randomized, double-blind trial from 2012 of 187 men who have progressed to
PSA Failure.
In the upper plot, Dutasteride increases the
Doubling Time
from, for example, 9 months to 18 months (factor of 2X). In
These two Kaplan-Meier plots compare Dutasteride (0.5 mg/day) to Placebo in a randomized, double-blind trial from 2012 of 187 men who have progressed to
PSA Failure.
In the upper plot, Dutasteride increases the
Doubling Time
from, for example, 9 months to 18 months (factor of 2X). In
janebob99
in
Prostate Cancer Network
6 months ago
Dutasteride increases PSA Doubling Time after PSA Recurrence
These two Kaplan-Meier plots compare Dutasteride (0.5 mg/day) to Placebo in a randomized, double-blind trial from 2012 of 187 men who have progressed to
PSA Failure.
In the upper plot, Dutasteride increases the
Doubling Time
from, for example, 9 months to 18 months (factor of 2X). In
These two Kaplan-Meier plots compare Dutasteride (0.5 mg/day) to Placebo in a randomized, double-blind trial from 2012 of 187 men who have progressed to
PSA Failure.
In the upper plot, Dutasteride increases the
Doubling Time
from, for example, 9 months to 18 months (factor of 2X). In
janebob99
in
Advanced Prostate Cancer
6 months ago
PSA and Eligard and bicalutamide
My PSA keep rising. Today, PSA went up to 1.1 (Today-03/13/24) from 0.37 (January). Doctor told me to take another Eljgard injection next week. This is the 2nd time. Doctor asked me to stop taking bicalutamide and dutasteride, as they appear not to be effective any longer. He said I solely rely
My PSA keep rising. Today, PSA went up to 1.1 (Today-03/13/24) from 0.37 (January). Doctor told me to take another Eljgard injection next week. This is the 2nd time. Doctor asked me to stop taking bicalutamide and dutasteride, as they appear not to be effective any longer. He said I solely rely
Domas
in
Advanced Prostate Cancer
7 months ago
Alfuzosin and Blocked Nose
Hi - this is my first post on Men's Health Forum (although I have posted on other HUL forums about other health matters that effect me). I have had symptoms of prostate enlargement for years and recently was checked out again, including having an MRI scan. The Urologist has confirmed that my prostate
Hi - this is my first post on Men's Health Forum (although I have posted on other HUL forums about other health matters that effect me). I have had symptoms of prostate enlargement for years and recently was checked out again, including having an MRI scan. The Urologist has confirmed that my prostate
FindingCaradoc
in
Men's Health Forum
5 months ago
Bang for your buck
Supplements, medication, procedures Can someone tell me what supplements should be used with Parkinsons Among the various therapies that have shown at least some effect in the animal and/or human model are Carbadopa/Levadopa Actylcholine Actigal/Ursolic acid Adderil (amphetamine) Alcohol Alpha
Supplements, medication, procedures Can someone tell me what supplements should be used with Parkinsons Among the various therapies that have shown at least some effect in the animal and/or human model are Carbadopa/Levadopa Actylcholine Actigal/Ursolic acid Adderil (amphetamine) Alcohol Alpha
heartinmotion
in
Cure Parkinson's
6 months ago
back to the drawing board with aches & pains
My OH was put on a 10-day course for what the doc suspected was a viral infection or a bronchial reaction to Tamsulosin. Hubby felt absolutely brilliant while taking the Pred, but since he stopped them 2 days ago, his old age aches & pains have returned. Hey ho. But so far he’s not had the return of
My OH was put on a 10-day course for what the doc suspected was a viral infection or a bronchial reaction to Tamsulosin. Hubby felt absolutely brilliant while taking the Pred, but since he stopped them 2 days ago, his old age aches & pains have returned. Hey ho. But so far he’s not had the return of
Doraflora
in
PMRGCAuk
6 months ago
Should the dose of Dutasteride be increased?
The plot above shows the residual (nadir) level of DHT in men as a function of the daily Dutasteride dose (mg/day). The DHT nadir numbers shown in this plot are: 23.8 pg/mL for 0.5 mg daily dose; 10.2 pg/mL for 2.5 mg daily dose; and 7.3 pg/mL for 5 mg daily dose. Ref: Clark (2004) [see Table
The plot above shows the residual (nadir) level of DHT in men as a function of the daily Dutasteride dose (mg/day). The DHT nadir numbers shown in this plot are: 23.8 pg/mL for 0.5 mg daily dose; 10.2 pg/mL for 2.5 mg daily dose; and 7.3 pg/mL for 5 mg daily dose. Ref: Clark (2004) [see Table
janebob99
in
Advanced Prostate Cancer
7 months ago
Should the dose of Dutasteride be increased?
The plot above shows the residual (nadir) level of DHT in men as a function of the daily Dutasteride dose (mg/day). The DHT nadir numbers shown in this plot are: 23.8 pg/mL for 0.5 mg daily dose; 10.2 pg/mL for 2.5 mg daily dose; and 7.3 pg/mL for 5 mg daily dose. Ref: Clark (2004) [see Table
The plot above shows the residual (nadir) level of DHT in men as a function of the daily Dutasteride dose (mg/day). The DHT nadir numbers shown in this plot are: 23.8 pg/mL for 0.5 mg daily dose; 10.2 pg/mL for 2.5 mg daily dose; and 7.3 pg/mL for 5 mg daily dose. Ref: Clark (2004) [see Table
janebob99
in
Prostate Cancer Network
7 months ago
Urinary incontinence in mCRPC
I am looking for help for my 81-year-old father who is mCRPC. He was diagnosed at stage 4 about 18 months ago with mets to 8+ bones including the skull. Summary of the following treatments: Bicalutamide this drug failed in July 2023 and the patient transitioned to Xtandi started in September 2023.
I am looking for help for my 81-year-old father who is mCRPC. He was diagnosed at stage 4 about 18 months ago with mets to 8+ bones including the skull. Summary of the following treatments: Bicalutamide this drug failed in July 2023 and the patient transitioned to Xtandi started in September 2023.
lgutman
in
Advanced Prostate Cancer
6 months ago
My own PSA values over time: 70% drop in just 3 months on Dutasteride and no ADT
Here are my own PSA values versus time plot. You can see there is an exponential rise in PSA starting at around 6/1/23, and doubling from PSA = 5 to 10 in about 8 months. My MRI at PSA = 10 showed a T3a tumor about 1.3 cm long (PIRADS 5). A subsequent targeted biopsy showed Gleason 3+4 in 4 cores,
Here are my own PSA values versus time plot. You can see there is an exponential rise in PSA starting at around 6/1/23, and doubling from PSA = 5 to 10 in about 8 months. My MRI at PSA = 10 showed a T3a tumor about 1.3 cm long (PIRADS 5). A subsequent targeted biopsy showed Gleason 3+4 in 4 cores,
janebob99
in
Prostate Cancer Network
7 months ago
SBRT process just starting
Hello and THANK YOU to all you brave and extremely knowledgeable folks for posting your priceless experiences and expertise here and to the brave spouses and partners as well. This Network has helped keep me sane since I was diagnosed with PC in 2023 and I could not decide on which way to deal with
Hello and THANK YOU to all you brave and extremely knowledgeable folks for posting your priceless experiences and expertise here and to the brave spouses and partners as well. This Network has helped keep me sane since I was diagnosed with PC in 2023 and I could not decide on which way to deal with
Info_Search_JMA
in
Prostate Cancer Network
6 months ago
Prednisolone - new member
my hubby never thought he’d be joining our Pred “gang”, but a trip to A&E yesterday (7 hours!!) showed that he’d either a bronchial reaction to the tamsulosin he was taking for his prostate, or he’s got a viral infection. He’s been prescribed 30mg for 10 days, which the doctor said would sort out either
my hubby never thought he’d be joining our Pred “gang”, but a trip to A&E yesterday (7 hours!!) showed that he’d either a bronchial reaction to the tamsulosin he was taking for his prostate, or he’s got a viral infection. He’s been prescribed 30mg for 10 days, which the doctor said would sort out either
Doraflora
in
PMRGCAuk
6 months ago
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