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Tamsulosin / Dutasteride
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5α-reductase inhibitors for benign prostate hypertrophy and risk of high-grade prostate cancer
New study below. Oh dear, it's been a few years since this issue was put to bed, & now this French study stirs things up again. Recall that both the PCPT (Prostate Cancer Prevention Trial, using Finasteride) & the REDUCE (Reduction by Dutasteride of Prostate Cancer Events) trials led to a significant
New study below. Oh dear, it's been a few years since this issue was put to bed, & now this French study stirs things up again. Recall that both the PCPT (Prostate Cancer Prevention Trial, using Finasteride) & the REDUCE (Reduction by Dutasteride of Prostate Cancer Events) trials led to a significant
pjoshea13
in
Advanced Prostate Cancer
6 years ago
BPH, retrograde ejaculation and mental health (newbie post)
Hi guys, this is my first post. I was diagnosed with benign prostatic hypersplasia last year and have been on several treatments since then, in an attempt to avoid their respective side effects. At the moment I'm on a combination of finasteride and prazosin, with a view to phasing out the prazosin once
Hi guys, this is my first post. I was diagnosed with benign prostatic hypersplasia last year and have been on several treatments since then, in an attempt to avoid their respective side effects. At the moment I'm on a combination of finasteride and prazosin, with a view to phasing out the prazosin once
Danny234
in
Men's Health Forum
6 years ago
Prazosin with Docetaxel?
New Australian cell study below [1]. Looks like Prazosin may increase Docetaxel-induced toxicity. "Some quinazoline-based alpha1-adrenoceptor (ADR) antagonists have previously been shown to have cytotoxic actions in PCa cells, but there is no research into their effects on docetaxel-induced toxicity.
New Australian cell study below [1]. Looks like Prazosin may increase Docetaxel-induced toxicity. "Some quinazoline-based alpha1-adrenoceptor (ADR) antagonists have previously been shown to have cytotoxic actions in PCa cells, but there is no research into their effects on docetaxel-induced toxicity.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
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LUTS OR BPH (Tamsulosin)
hi, quick background. l have primary Microvascular disease (whole body) l have the start of an heart attack weekly and l have had 5 major Attacks during the last 7 years, two of which stayed on long enough for them to say full NSTEMI’s. I have also had my gallbladder removed because of it, TIA’s (MVD
hi, quick background. l have primary Microvascular disease (whole body) l have the start of an heart attack weekly and l have had 5 major Attacks during the last 7 years, two of which stayed on long enough for them to say full NSTEMI’s. I have also had my gallbladder removed because of it, TIA’s (MVD
kel55
in
Sensitive Issues for Men
6 years ago
Umbilical Hernia
Things seem to going from bad to worse, Peeps, my husband’s Ascites has enlarged so hugely to the point his belly button has herniated. He saw his surgeon last Tuesday and he quadrupled his diuretics - Tamsulosin and Frumil - and he passes a reasonable amount of water in the mornings but that’s about
Things seem to going from bad to worse, Peeps, my husband’s Ascites has enlarged so hugely to the point his belly button has herniated. He saw his surgeon last Tuesday and he quadrupled his diuretics - Tamsulosin and Frumil - and he passes a reasonable amount of water in the mornings but that’s about
Peeps7
in
British Liver Trust
6 years ago
Backdoor Dihydrotestosterone [DHT] & CRPC.
New study below. "One mechanism that provides CaP resistance to ADT is primary backdoor androgen metabolism, which uses up to four 3α-oxidoreductases to convert 5α-androstane-3α,17β-diol (DIOL) to dihydrotestosterone (DHT)." In other words, a possible pathway to CRPC involves the generation of DHT other
New study below. "One mechanism that provides CaP resistance to ADT is primary backdoor androgen metabolism, which uses up to four 3α-oxidoreductases to convert 5α-androstane-3α,17β-diol (DIOL) to dihydrotestosterone (DHT)." In other words, a possible pathway to CRPC involves the generation of DHT other
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Strange case of my Dad's PCa
As many of you know, I have recently posted about my dad's Bone Mets PCa. Here's the strange part about my dad's case, I was hoping if someone experience this or know what's going on. My dad has been visiting urologist for the past two years, and did regular checks and taking Tamsulosin pills for urinating
As many of you know, I have recently posted about my dad's Bone Mets PCa. Here's the strange part about my dad's case, I was hoping if someone experience this or know what's going on. My dad has been visiting urologist for the past two years, and did regular checks and taking Tamsulosin pills for urinating
iLoveDad
in
Advanced Prostate Cancer
7 years ago
CRPC & Avodart [Dutasteride].
New study below. Some may recall that I'm in favor of shutting off all escape paths while on ADT - e.g. via Zytiga, Casodex, Simvastatin & Avodart. If you are closing the door, close the windows too. The conventional view is that since 5alpha-reductase converts testosterone [T] to dihtdrotestosterone
New study below. Some may recall that I'm in favor of shutting off all escape paths while on ADT - e.g. via Zytiga, Casodex, Simvastatin & Avodart. If you are closing the door, close the windows too. The conventional view is that since 5alpha-reductase converts testosterone [T] to dihtdrotestosterone
pjoshea13
in
Advanced Prostate Cancer
7 years ago
At what age can I stop Dutasteride?
What a wonderful forum! You folks seem to be most helpful about all the stress and anxiety of prostate concerns. It's nice to be here. My background... I'm 80. I've had 3 TURPs and after the last one, the doc took cell samples. One of the 50 tested samples came up positive for cancer at age 56. He
What a wonderful forum! You folks seem to be most helpful about all the stress and anxiety of prostate concerns. It's nice to be here. My background... I'm 80. I've had 3 TURPs and after the last one, the doc took cell samples. One of the 50 tested samples came up positive for cancer at age 56. He
OldFart81
in
Advanced Prostate Cancer
7 years ago
Cholesterol & High-Grade PCa.
New study [1]. Somewhat perplexing. It has been known for a century that solid tumors accumulate cholesterol. In PCa, cholesterol within cancer cells can be used to generate androgens. And, if cholesterol uptake is inhibited, the cells can manufacture cholesterol (unless prevented via a statin.) "
New study [1]. Somewhat perplexing. It has been known for a century that solid tumors accumulate cholesterol. In PCa, cholesterol within cancer cells can be used to generate androgens. And, if cholesterol uptake is inhibited, the cells can manufacture cholesterol (unless prevented via a statin.) "
pjoshea13
in
Advanced Prostate Cancer
7 years ago
I'm new here
I'm nearly 69, Gleason 7 (3+4), PSA 10.3, prostate normal size, the cancer appears to be isolated to the left side of prostate, diagnosed last month. I'm currently in Mazatlan, Mx, where the only option is open prostatectomy. I've talked with 2 Urologists and the biopsy MD. I have Medicare A, won't have
I'm nearly 69, Gleason 7 (3+4), PSA 10.3, prostate normal size, the cancer appears to be isolated to the left side of prostate, diagnosed last month. I'm currently in Mazatlan, Mx, where the only option is open prostatectomy. I've talked with 2 Urologists and the biopsy MD. I have Medicare A, won't have
Smallfall
in
Prostate Cancer Network
7 years ago
My Cancer Journey
I am a 7 year prostate cancer survivor. I am presently using lupron, zytiga, prednisone, xgeva, and dutasteride as my primary therapy. I have brca2 and bone metastecies. I will be going to provenge and olaparib in the next few weeks and hopefully not get any more spots on my spine. I have had Cyberknife
I am a 7 year prostate cancer survivor. I am presently using lupron, zytiga, prednisone, xgeva, and dutasteride as my primary therapy. I have brca2 and bone metastecies. I will be going to provenge and olaparib in the next few weeks and hopefully not get any more spots on my spine. I have had Cyberknife
hysir
in
Advanced Prostate Cancer
7 years ago
struggle taking tablets
I have been diagnosed with low grade prostate cancer and benigh prostatic enlargement. For the enlargement and poor urine flow i am prescribed Tamsulosin 400 microgram once a day.I struggle badly with side effects of these ,bad headache and dizziness and have improved little.I feel tablets could be useful
I have been diagnosed with low grade prostate cancer and benigh prostatic enlargement. For the enlargement and poor urine flow i am prescribed Tamsulosin 400 microgram once a day.I struggle badly with side effects of these ,bad headache and dizziness and have improved little.I feel tablets could be useful
melrose1
in
Men's Health Forum
7 years ago
BPH.
I've had BPH for about 10 years, I'm now in my 60's. I've taken one 400mg capsule of Tamsulosin per day after breakfast for the past 7 years. It does relieve the symptoms a bit during the day and apart from water-thin semen or even dry climax. There are no other bad side effects. However I have to get
I've had BPH for about 10 years, I'm now in my 60's. I've taken one 400mg capsule of Tamsulosin per day after breakfast for the past 7 years. It does relieve the symptoms a bit during the day and apart from water-thin semen or even dry climax. There are no other bad side effects. However I have to get
Tracker52
in
Men's Health Forum
7 years ago
New here - not sure whether to start medication
I would like some advice. I am a 66-year-old man. Because I suffer from enlarged prostate, I have an annual blood test to check my PSA levels, and this year my thyroid came up as slightly outside the normal parameters.The serum free T4 reading was 8.5 pmol/L and the serum TSH 5.47 mu/L. My doctor has
I would like some advice. I am a 66-year-old man. Because I suffer from enlarged prostate, I have an annual blood test to check my PSA levels, and this year my thyroid came up as slightly outside the normal parameters.The serum free T4 reading was 8.5 pmol/L and the serum TSH 5.47 mu/L. My doctor has
jd2387
in
Thyroid UK
7 years ago
Prostate Disease.
One Month ago My PSA was 8.17 U/ L. My Doctor prescribed me for 10 days to use Capsule Ciprofloxacin 500 mg 2 in a day aLongewith 1 Capsule Tamsulosin 0.4/0.5 mg daily. After 10 days PSA was tested which came to 5.37 U/ L. I urged my Dr. to continue antibiotic Ciprofloxacin for further 1Month. He didn't
One Month ago My PSA was 8.17 U/ L. My Doctor prescribed me for 10 days to use Capsule Ciprofloxacin 500 mg 2 in a day aLongewith 1 Capsule Tamsulosin 0.4/0.5 mg daily. After 10 days PSA was tested which came to 5.37 U/ L. I urged my Dr. to continue antibiotic Ciprofloxacin for further 1Month. He didn't
Ashraf82
in
Fight Prostate Cancer
7 years ago
Prostate Disease.
Dear Sirs, My 1st PSA report's was 8.17 U/ L. After using Ciprofloxacin 500 mg tabs 2 in a day for 10 days along with one Capsule of Tamsulosin 0.4mg/ 0.5 mg daily. Now yesterday 2nd psa report's result came as 5.37 U/ L. Can PSA will go down if I continue these medicines of 10 days more. Looking forward
Dear Sirs, My 1st PSA report's was 8.17 U/ L. After using Ciprofloxacin 500 mg tabs 2 in a day for 10 days along with one Capsule of Tamsulosin 0.4mg/ 0.5 mg daily. Now yesterday 2nd psa report's result came as 5.37 U/ L. Can PSA will go down if I continue these medicines of 10 days more. Looking forward
Ashraf82
in
Fight Prostate Cancer
7 years ago
Ground Flaxseed, Flaxsee Oil & Flaxseed Oil.
This is a follow-on from my Fred Kummerow post - in response to some questions. Flaxseed contains two elements that might affect PCa progression: lignans that might impede it & alpha-linolenic acid [ALA] that might accelerate it. A tablespoon of flaxseed oil contails a lot of ALA with little or none
This is a follow-on from my Fred Kummerow post - in response to some questions. Flaxseed contains two elements that might affect PCa progression: lignans that might impede it & alpha-linolenic acid [ALA] that might accelerate it. A tablespoon of flaxseed oil contails a lot of ALA with little or none
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Statin Use & Prostate Inflammation in the REDUCE Trial.
New study below [1]. (Another study from Dr. Steve Freedland.) First a recap of the REDUCE trial: "The Reduction by Dutasteride of Prostate Cancer Events clinical trial is an international, multicenter, double-blind, placebo controlled chemoprevention study designed to determine if dutasteride 0.5 mg
New study below [1]. (Another study from Dr. Steve Freedland.) First a recap of the REDUCE trial: "The Reduction by Dutasteride of Prostate Cancer Events clinical trial is an international, multicenter, double-blind, placebo controlled chemoprevention study designed to determine if dutasteride 0.5 mg
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Painkillers
'morning everyone - what a wonderful day it is today in Norfolk. I'd like advice please about anti-inflammatories please. My Husband who had his first AF attack early this year has been waiting for knee replacement (looks like two knees now unfortunately) He is now 86 but a very young and active 86 but
'morning everyone - what a wonderful day it is today in Norfolk. I'd like advice please about anti-inflammatories please. My Husband who had his first AF attack early this year has been waiting for knee replacement (looks like two knees now unfortunately) He is now 86 but a very young and active 86 but
excel1234
in
AF Association
8 years ago
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