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Tamsulosin / Dutasteride
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Dutasteride (5-ARI) extends time to disease progression in Low-Risk men on Active Surveillance, compared to Placebo
This study by Finelli et al. (2010) looks at the effect of Dutasteride (5-ARI) on the rate of prostate cancer disease progression in Low-Risk men on Active Surveillance. The use of a 5-ARI was associated with a significantly lower rate of pathologic disease progression and lower rate of abandonment
This study by Finelli et al. (2010) looks at the effect of Dutasteride (5-ARI) on the rate of prostate cancer disease progression in Low-Risk men on Active Surveillance. The use of a 5-ARI was associated with a significantly lower rate of pathologic disease progression and lower rate of abandonment
janebob99
in
Prostate Cancer Network
16 days ago
Reference Library of Papers about Dutasteride for Treating Prostate Cancer
Here is a library of 20 papers about using Dutasteride to treat prostate cancer. In one study, Dutasteride monotherapy reduces PSA by 50%, reduces prostate volume by 25%, and reduces tumor volume by 30%, after 6 months of treatment, compared to placebo (Moore, 2017). https://pubmed.ncbi.nlm.nih.gov
Here is a library of 20 papers about using Dutasteride to treat prostate cancer. In one study, Dutasteride monotherapy reduces PSA by 50%, reduces prostate volume by 25%, and reduces tumor volume by 30%, after 6 months of treatment, compared to placebo (Moore, 2017). https://pubmed.ncbi.nlm.nih.gov
janebob99
in
Advanced Prostate Cancer
19 days ago
Why don't doctors prescribe Dutasteride more often?
I get this question from a lot of men that have prostate cancer. Although the black label warning is a concern to some doctors, and has been discussed here in previous posts, I think the main reason is simply that most doctors don't know about it. Here is the single best paper reviewing the three major
I get this question from a lot of men that have prostate cancer. Although the black label warning is a concern to some doctors, and has been discussed here in previous posts, I think the main reason is simply that most doctors don't know about it. Here is the single best paper reviewing the three major
janebob99
in
Prostate Cancer Network
20 days ago
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Dutasteride reduces PSA by 40% over 6 months
This companion chart from data reported in Moore (2017) compares PSA, at baseline and at 6 months, comparing placebo to Dutasteride. This was a randomized, double-blind, placebo-controlled clinical trial. The cohort included Low and Intermediate Risk men, GS-6-7, baseline PSA = 6-7, median age 64 y.o
This companion chart from data reported in Moore (2017) compares PSA, at baseline and at 6 months, comparing placebo to Dutasteride. This was a randomized, double-blind, placebo-controlled clinical trial. The cohort included Low and Intermediate Risk men, GS-6-7, baseline PSA = 6-7, median age 64 y.o
janebob99
in
Prostate Cancer Network
28 days ago
Dutasteride Reduces Tumor Volume by 30% after 6 months.
This chart compares prostate cancer tumor volume measured by MRI, at baseline and at 6 months, comparing placebo to Dutasteride. This was a randomized, double-blind, placebo-controlled clinical trial. The cohort included Low and Intermediate Risk men, GS-6-7, baseline PSA = 6-7, median age 64 y.o,
This chart compares prostate cancer tumor volume measured by MRI, at baseline and at 6 months, comparing placebo to Dutasteride. This was a randomized, double-blind, placebo-controlled clinical trial. The cohort included Low and Intermediate Risk men, GS-6-7, baseline PSA = 6-7, median age 64 y.o,
janebob99
in
Prostate Cancer Network
28 days ago
Dutasteride Black Box Warning Label is Inappropriate.
This plot that I made goes back to the original paper by Thompson et al. (2003), that was the basis for slapping the Black Box Warning Label on Dutasteride prescriptions. https://pubmed.ncbi.nlm.nih.gov/12824459/ There are some important points that should be considered: (1) Thompson only studied
This plot that I made goes back to the original paper by Thompson et al. (2003), that was the basis for slapping the Black Box Warning Label on Dutasteride prescriptions. https://pubmed.ncbi.nlm.nih.gov/12824459/ There are some important points that should be considered: (1) Thompson only studied
janebob99
in
Prostate Cancer Network
1 month ago
Dutasteride Monotherapy is effective for Newly Diagnosed PCa men not on ADT
This plot shows men that either don't have PCa (Group A) or newly diagnosed men with PCa by biopsy (Group B). Neither group is on ADT. Dutasteride monotherapy (0.5 mg/day) causes an average drop in PSA of about 50% in both Groups, and an average drop of about 20% in prostate volume. In one man, his
This plot shows men that either don't have PCa (Group A) or newly diagnosed men with PCa by biopsy (Group B). Neither group is on ADT. Dutasteride monotherapy (0.5 mg/day) causes an average drop in PSA of about 50% in both Groups, and an average drop of about 20% in prostate volume. In one man, his
janebob99
in
Prostate Cancer Network
1 month ago
Dutssteride increases PSA Doubling Time by 2X for men with PSA Failure.
These two Kaplan-Meier plots compare Dutasteride (0.5 mg/day) to Placebo in a randomized, double-blind trial from 2012 of 187 men who have progressed to
PSA Failure.
In the upper plot, Dutasteride increases the
Doubling Time
from, for example, 9 months to 18 months (factor of 2X). In
These two Kaplan-Meier plots compare Dutasteride (0.5 mg/day) to Placebo in a randomized, double-blind trial from 2012 of 187 men who have progressed to
PSA Failure.
In the upper plot, Dutasteride increases the
Doubling Time
from, for example, 9 months to 18 months (factor of 2X). In
janebob99
in
Prostate Cancer Network
1 month ago
Dutasteride increases PSA Doubling Time after PSA Recurrence
These two Kaplan-Meier plots compare Dutasteride (0.5 mg/day) to Placebo in a randomized, double-blind trial from 2012 of 187 men who have progressed to
PSA Failure.
In the upper plot, Dutasteride increases the
Doubling Time
from, for example, 9 months to 18 months (factor of 2X). In
These two Kaplan-Meier plots compare Dutasteride (0.5 mg/day) to Placebo in a randomized, double-blind trial from 2012 of 187 men who have progressed to
PSA Failure.
In the upper plot, Dutasteride increases the
Doubling Time
from, for example, 9 months to 18 months (factor of 2X). In
janebob99
in
Advanced Prostate Cancer
1 month ago
PSA and Eligard and bicalutamide
My PSA keep rising. Today, PSA went up to 1.1 (Today-03/13/24) from 0.37 (January). Doctor told me to take another Eljgard injection next week. This is the 2nd time. Doctor asked me to stop taking bicalutamide and dutasteride, as they appear not to be effective any longer. He said I solely rely
My PSA keep rising. Today, PSA went up to 1.1 (Today-03/13/24) from 0.37 (January). Doctor told me to take another Eljgard injection next week. This is the 2nd time. Doctor asked me to stop taking bicalutamide and dutasteride, as they appear not to be effective any longer. He said I solely rely
Domas
in
Advanced Prostate Cancer
1 month ago
Should the dose of Dutasteride be increased?
The plot above shows the residual (nadir) level of DHT in men as a function of the daily Dutasteride dose (mg/day). The DHT nadir numbers shown in this plot are: 23.8 pg/mL for 0.5 mg daily dose; 10.2 pg/mL for 2.5 mg daily dose; and 7.3 pg/mL for 5 mg daily dose. Ref: Clark (2004) [see Table
The plot above shows the residual (nadir) level of DHT in men as a function of the daily Dutasteride dose (mg/day). The DHT nadir numbers shown in this plot are: 23.8 pg/mL for 0.5 mg daily dose; 10.2 pg/mL for 2.5 mg daily dose; and 7.3 pg/mL for 5 mg daily dose. Ref: Clark (2004) [see Table
janebob99
in
Advanced Prostate Cancer
2 months ago
Should the dose of Dutasteride be increased?
The plot above shows the residual (nadir) level of DHT in men as a function of the daily Dutasteride dose (mg/day). The DHT nadir numbers shown in this plot are: 23.8 pg/mL for 0.5 mg daily dose; 10.2 pg/mL for 2.5 mg daily dose; and 7.3 pg/mL for 5 mg daily dose. Ref: Clark (2004) [see Table
The plot above shows the residual (nadir) level of DHT in men as a function of the daily Dutasteride dose (mg/day). The DHT nadir numbers shown in this plot are: 23.8 pg/mL for 0.5 mg daily dose; 10.2 pg/mL for 2.5 mg daily dose; and 7.3 pg/mL for 5 mg daily dose. Ref: Clark (2004) [see Table
janebob99
in
Prostate Cancer Network
2 months ago
My own PSA values over time: 70% drop in just 3 months on Dutasteride and no ADT
Here are my own PSA values versus time plot. You can see there is an exponential rise in PSA starting at around 6/1/23, and doubling from PSA = 5 to 10 in about 8 months. My MRI at PSA = 10 showed a T3a tumor about 1.3 cm long (PIRADS 5). A subsequent targeted biopsy showed Gleason 3+4 in 4 cores,
Here are my own PSA values versus time plot. You can see there is an exponential rise in PSA starting at around 6/1/23, and doubling from PSA = 5 to 10 in about 8 months. My MRI at PSA = 10 showed a T3a tumor about 1.3 cm long (PIRADS 5). A subsequent targeted biopsy showed Gleason 3+4 in 4 cores,
janebob99
in
Prostate Cancer Network
2 months ago
Dental Issues on Finesteride
Five weeks after starting on finesteride 5 mg I developed painfully sensitive teeth both top and bottom on left side of my mouth. Here's what a google search turned up: https://forum.propeciahelp.com/t/propecia-and-dental-problems/1254 https://www.ehealthme.com/ds/finasteride/toothaches/ I became
Five weeks after starting on finesteride 5 mg I developed painfully sensitive teeth both top and bottom on left side of my mouth. Here's what a google search turned up: https://forum.propeciahelp.com/t/propecia-and-dental-problems/1254 https://www.ehealthme.com/ds/finasteride/toothaches/ I became
fast_eddie
in
Fight Prostate Cancer
3 months ago
Bicalutamide and Eligard
PSA went up to 0.87. Doctor recommend Eligard (Lupron) with bicalutimide and dutasteride. No choice. I went thru thus on Jan 10, 2024. Hospital said I have to run thru Eligard for 24 months on a quarterly basis. Every 3 month. Doctor Said Eligard works only for 2 years, and I have to find another
PSA went up to 0.87. Doctor recommend Eligard (Lupron) with bicalutimide and dutasteride. No choice. I went thru thus on Jan 10, 2024. Hospital said I have to run thru Eligard for 24 months on a quarterly basis. Every 3 month. Doctor Said Eligard works only for 2 years, and I have to find another
Domas
in
Advanced Prostate Cancer
3 months ago
Any Data or MO Advice Regarding Dutasteride / Finasteride At Very Early Biochemical Recurrence?
Does anyone know of any studies or MO advice they've gotten regarding use of Dutasteride or Finasteride at very early signs of Biochemical Reccurrence (uPSA in the 0.03 - 0.1 range) prior to Salvage Radiotherapy? It's obviously going to slow PSA doubling time and thereby probably lengthen the time
Does anyone know of any studies or MO advice they've gotten regarding use of Dutasteride or Finasteride at very early signs of Biochemical Reccurrence (uPSA in the 0.03 - 0.1 range) prior to Salvage Radiotherapy? It's obviously going to slow PSA doubling time and thereby probably lengthen the time
jazj
in
Advanced Prostate Cancer
3 months ago
PSA Response From Broccoli Sprout Extract (Sulforaphane) May Due To Just Being Moderate ADT
I forgot I ran across this a 2 years ago as many with PCa diagnosis are very interested in Sulforaphane due to a lot of excitement from a few studies a few years ago. (This fueled an explosion of supplements on Amazon.) This however is one of the more expensive supplements and my jury is still out
I forgot I ran across this a 2 years ago as many with PCa diagnosis are very interested in Sulforaphane due to a lot of excitement from a few studies a few years ago. (This fueled an explosion of supplements on Amazon.) This however is one of the more expensive supplements and my jury is still out
jazj
in
Advanced Prostate Cancer
3 months ago
Hashimotos - understanding latest blood test results - any advice for next steps?
Hi all, my partner (44F) has been struggling with hypothyroid / possible PCOS symptoms for ~18 months (thinning hair all over, some hirsutism and weight gain). She was diagnosed with Hashimotos in October 2022. We have been trying an approach to tackle both the thyroid issues and the hyperandrogenism
Hi all, my partner (44F) has been struggling with hypothyroid / possible PCOS symptoms for ~18 months (thinning hair all over, some hirsutism and weight gain). She was diagnosed with Hashimotos in October 2022. We have been trying an approach to tackle both the thyroid issues and the hyperandrogenism
Ehal89
in
Thyroid UK
4 months ago
Alfuzosin and Blocked Nose
Hi - this is my first post on Men's Health Forum (although I have posted on other HUL forums about other health matters that effect me). I have had symptoms of prostate enlargement for years and recently was checked out again, including having an MRI scan. The Urologist has confirmed that my prostate
Hi - this is my first post on Men's Health Forum (although I have posted on other HUL forums about other health matters that effect me). I have had symptoms of prostate enlargement for years and recently was checked out again, including having an MRI scan. The Urologist has confirmed that my prostate
FindingCaradoc
in
Men's Health Forum
4 days ago
Bang for your buck
Supplements, medication, procedures Can someone tell me what supplements should be used with Parkinsons Among the various therapies that have shown at least some effect in the animal and/or human model are Carbadopa/Levadopa Actylcholine Actigal/Ursolic acid Adderil (amphetamine) Alcohol Alpha
Supplements, medication, procedures Can someone tell me what supplements should be used with Parkinsons Among the various therapies that have shown at least some effect in the animal and/or human model are Carbadopa/Levadopa Actylcholine Actigal/Ursolic acid Adderil (amphetamine) Alcohol Alpha
heartinmotion
in
Cure Parkinson's
10 days ago
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