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PROTAC: An Effective Targeted Protein Degradation Strategy for Cancer Therapy
Here is one out of far left field https://www.frontiersin.org/articles/10.3389/fphar.2021.692574/full PROTAC: An Effective Targeted Protein Degradation Strategy for Cancer Therapy www.frontiersin.orgSi-Min Qi1†, www.frontiersin.orgJinyun Dong2†, www.frontiersin.orgZhi-Yuan Xu2, www.frontiersin.orgXiang-Dong
Here is one out of far left field https://www.frontiersin.org/articles/10.3389/fphar.2021.692574/full PROTAC: An Effective Targeted Protein Degradation Strategy for Cancer Therapy www.frontiersin.orgSi-Min Qi1†, www.frontiersin.orgJinyun Dong2†, www.frontiersin.orgZhi-Yuan Xu2, www.frontiersin.orgXiang-Dong
Scout4answers
in
Advanced Prostate Cancer
2 years ago
Mitochondria?
dysfunction and neurodegeneration in a PINK1 model of Parkinson’s disease http://www.ncbi.nlm....les/PMC4199097/ Cinnamon Treatment Upregulates Neuroprotective Proteins Parkin and DJ-1 and Protects Dopaminergic Neurons in a Mouse Model of Parkinson’s Disease http://www.ncbi.nlm....les/PMC4167597/
Sodium
dysfunction and neurodegeneration in a PINK1 model of Parkinson’s disease http://www.ncbi.nlm....les/PMC4199097/ Cinnamon Treatment Upregulates Neuroprotective Proteins Parkin and DJ-1 and Protects Dopaminergic Neurons in a Mouse Model of Parkinson’s Disease http://www.ncbi.nlm....les/PMC4167597/
Sodium
kaypeeoh
in
Cure Parkinson's
3 years ago
Does anyone has this rare kidney disease (familial hypercalciuria, hypomagnesemia and nephrocalsinosis)?
Not a single doctor figured out a way to treat my condition or in other words nothing worked for me like: (
sodium
citrate, potassium citrate, potassium bicarbonate). Does anyone has this condition? I’m trying to prevent dialysis and kidney failure with a healthy diet only.
Not a single doctor figured out a way to treat my condition or in other words nothing worked for me like: (
sodium
citrate, potassium citrate, potassium bicarbonate). Does anyone has this condition? I’m trying to prevent dialysis and kidney failure with a healthy diet only.
Serlo92
in
Kidney Disease
2 years ago
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Where to buy affordable Enzalutamide?
Just wondering if its possible to buy this drug anywhere at reasonable prices? I know I can get generic abiraterone from India which can be affordable. Only problem is my dad already has had abiraterone many years ago and I would like to add enzalutamide to radium 223 which has been proven safe and more
Just wondering if its possible to buy this drug anywhere at reasonable prices? I know I can get generic abiraterone from India which can be affordable. Only problem is my dad already has had abiraterone many years ago and I would like to add enzalutamide to radium 223 which has been proven safe and more
Howmuchisthefish
in
Advanced Prostate Cancer
2 years ago
Understanding your blood test
Serum
level (range 132 - 146) A
sodium
blood test is a routine test that allows your doctor to see how much
sodium
is in your blood. It's also called a serum
sodium
test.
Sodium
is an essential mineral to your body. It's also referred to as Na+.
Serum
level (range 132 - 146) A
sodium
blood test is a routine test that allows your doctor to see how much
sodium
is in your blood. It's also called a serum
sodium
test.
Sodium
is an essential mineral to your body. It's also referred to as Na+.
Quercus53
in
MPN Voice
3 years ago
Liothyronine Sodium Vs Liothyronine Hydrochloride T3
Hi, I'm currently on T3 - Liothyronine
Sodium
by SigmaPharm, 10mcg (5mcg twice). However my pharmacy have said they can get the Thybon Henning 20, which is Liothyronine Hydrochloride for free. I was paying for the other T3. I just need my endocrinologist to specify the Thybon Henning version.
Hi, I'm currently on T3 - Liothyronine
Sodium
by SigmaPharm, 10mcg (5mcg twice). However my pharmacy have said they can get the Thybon Henning 20, which is Liothyronine Hydrochloride for free. I was paying for the other T3. I just need my endocrinologist to specify the Thybon Henning version.
ronzo888
in
Thyroid UK
2 years ago
A new T3 derivative shows promise in treatment with T3 and smaller FT3 spikes after taking it
They were randomly assigned to treatment sequence arms and were given one dose of placebo, PZL containing 50 µg of T3, or
sodium
-T3 containing 50 µg of T3 in identical capsules coated for duodenal delivery.
They were randomly assigned to treatment sequence arms and were given one dose of placebo, PZL containing 50 µg of T3, or
sodium
-T3 containing 50 µg of T3 in identical capsules coated for duodenal delivery.
diogenes
in
Thyroid UK
3 years ago
Radium 223
I just completed radium 223 number two both times I seem to have blood in my urine. Is anyone else on this blog had the same issue. Any response gratefully accepted.
I just completed radium 223 number two both times I seem to have blood in my urine. Is anyone else on this blog had the same issue. Any response gratefully accepted.
Goldberg
in
Advanced Prostate Cancer
2 years ago
General question
In blood
sodium
chloride went down below normal so 131[range 134 145] cl 92 [96 106] efgr 88.
In blood
sodium
chloride went down below normal so 131[range 134 145] cl 92 [96 106] efgr 88.
Anxoiusguy
in
Early CKD Support
3 years ago
My #1 support person & me
I'm new to the form. I have mcrpc. I was on lupron injections for almost 1 year. I didn’t like the pain for 5 days after injection plus insurance only paid half the cost so I got an orchiectomy. I don’t regret that. Several months after the orchiectomy, my PSA level went up so my urologist said it’s
I'm new to the form. I have mcrpc. I was on lupron injections for almost 1 year. I didn’t like the pain for 5 days after injection plus insurance only paid half the cost so I got an orchiectomy. I don’t regret that. Several months after the orchiectomy, my PSA level went up so my urologist said it’s
Canis-Lupus53
in
Advanced Prostate Cancer
2 years ago
Vitamin advice
In addition to the photo, they also contain the following:- Lutein Molybdenum Fruit/vegetable powders and botanicals blend Zinc Iron Vitamin E ⑧73% 100ug 75ug 100mg Vitamin B12
Sodium
Borate Vitamin C Thank you in advance.
In addition to the photo, they also contain the following:- Lutein Molybdenum Fruit/vegetable powders and botanicals blend Zinc Iron Vitamin E ⑧73% 100ug 75ug 100mg Vitamin B12
Sodium
Borate Vitamin C Thank you in advance.
CornishChick
in
Thyroid UK
3 years ago
Decision time. Input welcome
Saw my MO yesterday. I need to make a decision by next week on how to proceed. My personal life is imploding and all I see there is having to sell my house and move to... someplace -- long story, but everything I've tried has come up short. BTW, I live by myself with no close friends and only a very
Saw my MO yesterday. I need to make a decision by next week on how to proceed. My personal life is imploding and all I see there is having to sell my house and move to... someplace -- long story, but everything I've tried has come up short. BTW, I live by myself with no close friends and only a very
Miccoman
in
Advanced Prostate Cancer
2 years ago
Does anyone have a Low sodium level?
My levels are super low, Hyponatremia like. Docs have told me it’s related to AMN, but they seem to blame it for everything 😊
My levels are super low, Hyponatremia like. Docs have told me it’s related to AMN, but they seem to blame it for everything 😊
3WheelWonder
in
AMN EASIER
3 years ago
Can Ketone Esters provide Ketones without a Ketone diet?
Back in 2013, Dr. Mary Newport gave a Ted talk on her re-discovery of MCT oil (she'd been aware of it for several years). In short, it greatly helped her husband with AZ. More recently, Ketone Esters are said to be even more potent than MCT oil. This video is from Dr Newport's talk. I've started looking
Back in 2013, Dr. Mary Newport gave a Ted talk on her re-discovery of MCT oil (she'd been aware of it for several years). In short, it greatly helped her husband with AZ. More recently, Ketone Esters are said to be even more potent than MCT oil. This video is from Dr Newport's talk. I've started looking
JAS9
in
Cure Parkinson's
2 years ago
CKD minerals and labs?
Sodium
calcium etc? Asking because my dad has consistently high potassium and low
sodium
. But right now he’s having mild edema on his legs. Our nephro keeps saying he is dehydrated and has given his en electrolyte drink to take 3x a day, but we have reduced it to 1/day due to the edema.
Sodium
calcium etc? Asking because my dad has consistently high potassium and low
sodium
. But right now he’s having mild edema on his legs. Our nephro keeps saying he is dehydrated and has given his en electrolyte drink to take 3x a day, but we have reduced it to 1/day due to the edema.
Slaxx
in
Kidney Disease
3 years ago
Blood work results.
My
sodium
is 131 (135-146) Vit D-OH total: 29 (30-100) Vit D-OH D3 : 29 Vit D. 25 OH, D2 : <4 Testosterone : 40 (2-45) TSH: 0.51 (0.4-4.5) T4 Free: 1.4 (0.8-1.8) T3 Free: 2.3 ((2.3 -4.2) Estradiol: 179 (Perimenopause.
My
sodium
is 131 (135-146) Vit D-OH total: 29 (30-100) Vit D-OH D3 : 29 Vit D. 25 OH, D2 : <4 Testosterone : 40 (2-45) TSH: 0.51 (0.4-4.5) T4 Free: 1.4 (0.8-1.8) T3 Free: 2.3 ((2.3 -4.2) Estradiol: 179 (Perimenopause.
Hidden
in
Thyroid UK
3 years ago
Can’t figure it all out
So my husband went to the hospital today they said his GFR has dropped from 32 about a month ago now it’s 27, his creatinine is 216 umo1/L
Sodium
140mmo1/L Potassium 3.9mmo1/L So maybe you could shine more light on it for me. Thank you
So my husband went to the hospital today they said his GFR has dropped from 32 about a month ago now it’s 27, his creatinine is 216 umo1/L
Sodium
140mmo1/L Potassium 3.9mmo1/L So maybe you could shine more light on it for me. Thank you
42108
in
Kidney Disease
3 years ago
Roma – Liothyronine Sodium Hard Capsules
[i] Roma – Liothyronine
Sodium
Hard Capsules Marketing authorisation holder ROMA Pharmaceuticals Limited Gibraltar House, Manufactured by Galenica Pharmaceutical Industry S.A., Greece Being marketed as from 13/01/2022[/i] https://www.romapharma.co.uk/ [i]No lactose ingredient [/
[i] Roma – Liothyronine
Sodium
Hard Capsules Marketing authorisation holder ROMA Pharmaceuticals Limited Gibraltar House, Manufactured by Galenica Pharmaceutical Industry S.A., Greece Being marketed as from 13/01/2022[/i] https://www.romapharma.co.uk/ [i]No lactose ingredient [/
helvella
Thyroid UK
in
Thyroid UK
3 years ago
Spironolactone and sodium
Should doctor monitor kidneys and
sodium
/potassium levels while taking spironolactone 50mg? If yes how often?
Should doctor monitor kidneys and
sodium
/potassium levels while taking spironolactone 50mg? If yes how often?
Bazinga89
in
British Liver Trust
3 years ago
Loperamide or Budenoside
I have just been diagnosed with collagenous colitis and have a telephone appointment next week. From my research budenoside is a recommended treatment but my GP said it’s usually loperamide which is the same as Imodium. I’ve been using Imodium but as soon as it wears off the diarrhoea returns. Anyone
I have just been diagnosed with collagenous colitis and have a telephone appointment next week. From my research budenoside is a recommended treatment but my GP said it’s usually loperamide which is the same as Imodium. I’ve been using Imodium but as soon as it wears off the diarrhoea returns. Anyone
Xzbv
in
Crohn's and Colitis Support
2 years ago
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