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AI and prostate cancer, early days, but interesting
https://www.medindia.net/news/ai-reveals-subtypes-in-prostate-cancer-enhancing-treatment-215102-1.htm Apparently AI has helped analyze PCa from micro and macro evolutionary perspective and identified two sub types. "Our research demonstrates that prostate tumors evolve along multiple pathways, leading
https://www.medindia.net/news/ai-reveals-subtypes-in-prostate-cancer-enhancing-treatment-215102-1.htm Apparently AI has helped analyze PCa from micro and macro evolutionary perspective and identified two sub types. "Our research demonstrates that prostate tumors evolve along multiple pathways, leading
FRTHBST
in
Prostate Cancer Network
3 months ago
Non metastasis castrate resistant
When you are on ADT and become Non metastatic Castrate resistant and your testosterone levels are below zero, what is the cancer feeding off to cause the PSA to still rise? Hoping for your replies so as to give me some understanding. Thank you.
When you are on ADT and become Non metastatic Castrate resistant and your testosterone levels are below zero, what is the cancer feeding off to cause the PSA to still rise? Hoping for your replies so as to give me some understanding. Thank you.
Sailameme
in
Advanced Prostate Cancer
3 months ago
MY pBAT Stats From June to March 8 months
Hi All, Just thought I would give an update on my pBAT (Testosterone propianate BAT) for the last 8 months. I do T propianate injections every other day while on High T for 2 weeks then slam the door with Darolutamide for 2 weeks and then one week to clear the Daro. Rinse and repeat. I also take intermittent
Hi All, Just thought I would give an update on my pBAT (Testosterone propianate BAT) for the last 8 months. I do T propianate injections every other day while on High T for 2 weeks then slam the door with Darolutamide for 2 weeks and then one week to clear the Daro. Rinse and repeat. I also take intermittent
KocoPr
in
Fight Prostate Cancer
3 months ago
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What AI should i be using for my cancer research
I constantly am searching articles on prostate cancer and it is so easy to go off on infinite tangents and never come up with a clear plan. I see AI is very helpful and I see it as taking a big part in the future of fighting this beast. Any suggestions on which AI to utilize for this adventure?
I constantly am searching articles on prostate cancer and it is so easy to go off on infinite tangents and never come up with a clear plan. I see AI is very helpful and I see it as taking a big part in the future of fighting this beast. Any suggestions on which AI to utilize for this adventure?
KocoPr
in
Advanced Prostate Cancer
3 months ago
Questions after scan results
I have just been told my cancer has returned this time to my liver mainly. I wasn’t aware my ca 125 levels had increased from 36 end September to 350 recently. I had always been told my bloods were good and didn’t question further. When I shared symptoms earlier this month of cramping etc my oncologist
I have just been told my cancer has returned this time to my liver mainly. I wasn’t aware my ca 125 levels had increased from 36 end September to 350 recently. I had always been told my bloods were good and didn’t question further. When I shared symptoms earlier this month of cramping etc my oncologist
Tallulah55
in
My Ovacome
3 months ago
Examining Prostate Cancer Survival Outcomes by Patient Age and Treatment Type in Patients with mHSPC
“the research suggests a differential impact between androgen receptor antagonists (like enzalutamide, apalutamide, and darolutamide) and androgen synthesis inhibitors (such as abiraterone), with antagonists showing a more pronounced benefit” https://www.urotoday.com/video-lectures/asco-gu-2024/video
“the research suggests a differential impact between androgen receptor antagonists (like enzalutamide, apalutamide, and darolutamide) and androgen synthesis inhibitors (such as abiraterone), with antagonists showing a more pronounced benefit” https://www.urotoday.com/video-lectures/asco-gu-2024/video
Maxone73
in
Advanced Prostate Cancer
3 months ago
Just some new Information about AI
Came across this article a couple days ago. https://www.news-medical.net/news/20210924/Researchers-identify-two-subtypes-of-metastatic-prostate-cancer.aspx#:~:text=Building%20off%20of%20earlier%20studies%20that%20discovered%20clinically,into%20two%20types%20known%20as%20luminal%20and%20basal AI has
Came across this article a couple days ago. https://www.news-medical.net/news/20210924/Researchers-identify-two-subtypes-of-metastatic-prostate-cancer.aspx#:~:text=Building%20off%20of%20earlier%20studies%20that%20discovered%20clinically,into%20two%20types%20known%20as%20luminal%20and%20basal AI has
chefjlu
in
Advanced Prostate Cancer
3 months ago
I would like to connect with fellow warriors that are HSPC and on Darolutamide to discuss Time to Failure, early detection assays etc...
The failure mechanisms I have found so far are 1) Aldoketo Reductase 1C3 which is back door for DHT production. 2) Neuroendocrine which is a very bad cancer to get and is
small
cell
cancer
that is similar to
small
cell
lung
cancer
and treated the same as SCLC. 3) There are no AR variants or androgen
The failure mechanisms I have found so far are 1) Aldoketo Reductase 1C3 which is back door for DHT production. 2) Neuroendocrine which is a very bad cancer to get and is
small
cell
cancer
that is similar to
small
cell
lung
cancer
and treated the same as SCLC. 3) There are no AR variants or androgen
KocoPr
in
Advanced Prostate Cancer
1 year ago
Revised Plot of PSA vs Testosterone: Estrogen vs Lupron ADT
Ugh...I made a BIG mistake on the previous posting! I just realized that Dr. Morgentaler had listed the Testosterone level in unusual units (
ng/mL
), not the usual units of (
ng/dL)
. So, my X-axis was off by a factor of 10. Here is the revised plot. The exciting discovery is that the
Ugh...I made a BIG mistake on the previous posting! I just realized that Dr. Morgentaler had listed the Testosterone level in unusual units (
ng/mL
), not the usual units of (
ng/dL)
. So, my X-axis was off by a factor of 10. Here is the revised plot. The exciting discovery is that the
janebob99
in
Advanced Prostate Cancer
3 months ago
Morgentaler Saturation Model: PSA vs Testosterone - Estrogen Patch vs Lupron ADT
This is a plot of % reduction in PSA from a Maximum Value versus Testosterone, for two different datasets: Estrogen Patch and Lupron ADT. Both curves (red and green lines) show a linear response starting from (0,0), up to about 200-250 ng/dL. Then, the lines curve over to a lower slope (especially
This is a plot of % reduction in PSA from a Maximum Value versus Testosterone, for two different datasets: Estrogen Patch and Lupron ADT. Both curves (red and green lines) show a linear response starting from (0,0), up to about 200-250 ng/dL. Then, the lines curve over to a lower slope (especially
janebob99
in
Advanced Prostate Cancer
3 months ago
PSA vs Testosterone at high T levels - Linear Model
This is a plot of PSA versus Testosterone in men with prostate cancer. The blue points are taken from a YouTube video lecture by A. Morgentaler (2020). https://www.youtube.com/watch?v=wafNZV-Hkqk The green point is from Safraidi (2022): https://oamjms.eu/index.php/mjms/article/view/9388 Note the
This is a plot of PSA versus Testosterone in men with prostate cancer. The blue points are taken from a YouTube video lecture by A. Morgentaler (2020). https://www.youtube.com/watch?v=wafNZV-Hkqk The green point is from Safraidi (2022): https://oamjms.eu/index.php/mjms/article/view/9388 Note the
janebob99
in
Advanced Prostate Cancer
3 months ago
Reminder to Subscribe to our Prostate Cancer Community Newsletter
Please don't forget to subscribe to our community newsletter. It's free and helpful. Click here: https://malecare.org/prostate-cancer-newsletter/
Please don't forget to subscribe to our community newsletter. It's free and helpful. Click here: https://malecare.org/prostate-cancer-newsletter/
Darryl
Partner
in
Advanced Prostate Cancer
3 months ago
PSMA Scan to be scheduled - thank you Tall Allen
I want to thank Tall Allen for his suggestion that I see an oncologist. I had a RP followed by radiation in 2013. My PSA was undetectable until 2021, when it started to rise. This week I saw a radiation oncologist (whom I found through a friend) to ask him a lot of questions and to get his advice.
I want to thank Tall Allen for his suggestion that I see an oncologist. I had a RP followed by radiation in 2013. My PSA was undetectable until 2021, when it started to rise. This week I saw a radiation oncologist (whom I found through a friend) to ask him a lot of questions and to get his advice.
Geno2853
in
Advanced Prostate Cancer
3 months ago
PSA-Nadir vs Testosterone-Nadir comparing Non-CRPC to CRPX men
These plots show the linear relationship between median PSA-Nadir and median Testosterone-Nadir, pointing towards the Origin (i.e., 0 PSA-Nadir at 0 T-Nadir.). N= 38 men. The upper to graphs compare median PSA-nadir and median T-Nadir for Non-CRPC and CPRC groups (CPRC = Castrate Resistant Prostate
These plots show the linear relationship between median PSA-Nadir and median Testosterone-Nadir, pointing towards the Origin (i.e., 0 PSA-Nadir at 0 T-Nadir.). N= 38 men. The upper to graphs compare median PSA-nadir and median T-Nadir for Non-CRPC and CPRC groups (CPRC = Castrate Resistant Prostate
janebob99
in
Advanced Prostate Cancer
3 months ago
Elevated CA125 from 11 to 156.
My CA 125 is normally around 11 and that’s elevated to 156 within six months. My oncologist has done PET scan, CAT scan, MRIs, and has found no tumors. I just wanted to know if is there anyone that has elevated CA, 125 that are in remission.
My CA 125 is normally around 11 and that’s elevated to 156 within six months. My oncologist has done PET scan, CAT scan, MRIs, and has found no tumors. I just wanted to know if is there anyone that has elevated CA, 125 that are in remission.
marmay88o
in
My Ovacome
3 months ago
ADT response and questions for MO
Hi, I am newish to this forum, still on a steep learning curve but I want to thank you for your contributions and discussions. This is my first time posting. My partner is 60 yrs old, as I understand it he had low PSA 3 yrs ago, not tested until Nov 2023, PSA50, stage 4, 1 met in 'sit' bone. Started
Hi, I am newish to this forum, still on a steep learning curve but I want to thank you for your contributions and discussions. This is my first time posting. My partner is 60 yrs old, as I understand it he had low PSA 3 yrs ago, not tested until Nov 2023, PSA50, stage 4, 1 met in 'sit' bone. Started
Lovecherries
in
Advanced Prostate Cancer
3 months ago
One questions doctors never seem to be able to answer is at what PSA level do you start to experience pain or physical problems?
One questions doctors never seem to be able to answer is at what PSA level do you start to experience pain or physical problems? If you have had surgery, Salvage Radiation, ADT, SRBT and then stopped ADT with a continuing rise in you PSA when did you start to have pain or physical problems?
One questions doctors never seem to be able to answer is at what PSA level do you start to experience pain or physical problems? If you have had surgery, Salvage Radiation, ADT, SRBT and then stopped ADT with a continuing rise in you PSA when did you start to have pain or physical problems?
Exrunner
in
Advanced Prostate Cancer
3 months ago
Enzalutamide vs Lupron Survival
This shows the main results of the EMBARK trial, comparing Metatasis Free Survival and PSA Recurrence Free Survival for three groups: Enzalutamide only, Lupron only, or combined Enzalutamide + Lupron. The best survivals were for the combination of Enzalutamide + Lupron. Enzalutamide is a 2nd generation
This shows the main results of the EMBARK trial, comparing Metatasis Free Survival and PSA Recurrence Free Survival for three groups: Enzalutamide only, Lupron only, or combined Enzalutamide + Lupron. The best survivals were for the combination of Enzalutamide + Lupron. Enzalutamide is a 2nd generation
janebob99
in
Prostate Cancer Network
3 months ago
Help to do BAT treatment for my dad. Located in Norway.
Hello everyone! Writing on behalf of my father who is 67 yo and has prostate cancer. We are based in Norway. Prostatectomy done in March -17. Treated with Bicalutamide and Zoladex injection until rise in PSA 18 months ago. Increasing PSA from 6-12 on chemotherapy through last summer. September he was
Hello everyone! Writing on behalf of my father who is 67 yo and has prostate cancer. We are based in Norway. Prostatectomy done in March -17. Treated with Bicalutamide and Zoladex injection until rise in PSA 18 months ago. Increasing PSA from 6-12 on chemotherapy through last summer. September he was
VonKantarellen
in
Advanced Prostate Cancer
3 months ago
Do testosterone supplements help raise testosterone levels after use of Lupron with radiation?
trying to decide to decide between surgery and radiation w/Lupron as a treatment for prostate cancer. I’m particularly concerned with how long it takes to restore testerone levels after 6 months on Lupron. Does the use of testerone supplements help restore T levels more quickly?
trying to decide to decide between surgery and radiation w/Lupron as a treatment for prostate cancer. I’m particularly concerned with how long it takes to restore testerone levels after 6 months on Lupron. Does the use of testerone supplements help restore T levels more quickly?
Godfather2
in
Prostate Cancer Network
3 months ago
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